EIF2AK2 and STRBP

Number of citations of the paper that reports this interaction (PMID 10684936)
5

Data Source:
HPRD (in vivo)

		EIF2AK2	STRBP
Gene Name		eukaryotic translation initiation factor 2-alpha kinase 2	spermatid perinuclear RNA binding protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Type 2A Regulator Activity Poly(A) RNA Binding	DNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Poly(A) RNA Binding
	Biological Process	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Transcription, DNA-templated Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Modulation By Virus Of Host Process Viral Life Cycle Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Movement Of Cell Or Subcellular Component Multicellular Organismal Development Spermatid Development Mechanosensory Behavior
Pathways		ISG15 antiviral mechanism Interferon Signaling Inhibition of PKR Cytokine Signaling in Immune system Host Interactions with Influenza Factors Influenza Infection NS1 Mediated Effects on Host Pathways Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 HIST2H2AC HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PRKRIR PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 TIRAP TOLLIP TP53 TYK2 ZNF346	7 interactors: ARNT DAB1 EIF2AK2 LRRK2 RBPMS TARBP2 THAP1
Entrez ID		5610	55342
HPRD ID		01468	10257
Ensembl ID		ENSG00000055332	ENSG00000165209
Uniprot IDs		B7ZKK7 P19525 Q8IW76	Q96SI9
PDB IDs		1QU6 2A19 2A1A 3UIU	2DMY
Enriched GO Terms of Interacting Partners?		Immune Response Defense Response Immune System Process Innate Immune Response Response To Stress Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Response To Stimulus Regulation Of Cell Death Response To External Stimulus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Fc Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Signal Transduction Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posttranscriptional Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Biotic Stimulus Response To Abiotic Stimulus Signaling Response To Growth Factor Response To Virus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Response To DsRNA Positive Regulation Of Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway	Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Defense Response To Virus Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Activation Of MAPKK Activity Regulation Of Viral Genome Replication Positive Regulation Of Signal Transduction Regulation Of Defense Response To Virus Positive Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Kinase Activity Evasion Or Tolerance By Virus Of Host Immune Response Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation Negative Regulation Of Peroxidase Activity Regulation Of Metabolic Process Telencephalon Cell Migration Regulation Of Signal Transduction Forebrain Cell Migration Positive Regulation Of Transferase Activity Regulation Of Stem Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of Protein Autoubiquitination MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Cerebellum Structural Organization Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Signaling RNA Metabolic Process Regulation Of Viral Process Regulation Of Protein Autoubiquitination Positive Regulation Of Dopamine Receptor Signaling Pathway Targeting Of MRNA For Destruction Involved In RNA Interference Cellular Response To Dopamine Lateral Motor Column Neuron Migration Evasion Or Tolerance Of Host Defenses By Virus Positive Regulation Of Metabolic Process Gene Expression Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Tagcloud ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x	accurately affymetrix architectural beagle bph calcification canine confirming detoxification dog dynamic fkbp1b gst itih3 mgp mimicked mmp2 mt2a muc1 prostatic qpcr spite suitability sult1a1 tff3 tgfb3 timp2 transcriptome transdifferentiation
Tagcloud (Difference) ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x	accurately affymetrix architectural beagle bph calcification canine confirming detoxification dog dynamic fkbp1b gst itih3 mgp mimicked mmp2 mt2a muc1 prostatic qpcr spite suitability sult1a1 tff3 tgfb3 timp2 transcriptome transdifferentiation
Tagcloud (Intersection) ?