EIF2AK2 and PPP2R5A

Number of citations of the paper that reports this interaction (PMID 10866685)
28

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		EIF2AK2	PPP2R5A
Gene Name		eukaryotic translation initiation factor 2-alpha kinase 2	protein phosphatase 2, regulatory subunit B, alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Membrane Z Disc M Band
	Molecular Function	Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Type 2A Regulator Activity Poly(A) RNA Binding	Protein Binding Protein Phosphatase Type 2A Regulator Activity Kinase Binding
	Biological Process	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Transcription, DNA-templated Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Modulation By Virus Of Host Process Viral Life Cycle Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Signal Transduction Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Lipid Kinase Activity
Pathways		ISG15 antiviral mechanism Interferon Signaling Inhibition of PKR Cytokine Signaling in Immune system Host Interactions with Influenza Factors Influenza Infection NS1 Mediated Effects on Host Pathways Antiviral mechanism by IFN-stimulated genes	Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Mitotic Anaphase Signaling by Wnt M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling CTLA4 inhibitory signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Cell Cycle, Mitotic Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 HIST2H2AC HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PRKRIR PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 TIRAP TOLLIP TP53 TYK2 ZNF346	18 interactors: APC BCL2 BEST1 CHEK2 CSNK1A1 CTLA4 EIF2AK2 GNL3 JAK2 MAPT NEK1 NOS3 PPP2R1A PTTG1 PYGM SGOL1 SHC1 TP63
Entrez ID		5610	5525
HPRD ID		01468	03384
Ensembl ID		ENSG00000055332	ENSG00000066027
Uniprot IDs		B7ZKK7 P19525 Q8IW76	Q15172
PDB IDs		1QU6 2A19 2A1A 3UIU
Enriched GO Terms of Interacting Partners?		Immune Response Defense Response Immune System Process Innate Immune Response Response To Stress Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Response To Stimulus Regulation Of Cell Death Response To External Stimulus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Fc Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Signal Transduction Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posttranscriptional Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Biotic Stimulus Response To Abiotic Stimulus Signaling Response To Growth Factor Response To Virus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Response To DsRNA Positive Regulation Of Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway	Mitotic Cell Cycle Process Cell Division Organelle Organization Cellular Response To Stress Mitotic Cell Cycle Regulation Of Protein Metabolic Process Mitotic Nuclear Division Positive Regulation Of Signal Transduction Cell Cycle Process Regulation Of Cell Proliferation Cellular Response To DNA Damage Stimulus Regulation Of Catalytic Activity Cell Cycle Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Apoptotic Process Positive Regulation Of Cell Death Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Phosphorus Metabolic Process Cell Death Negative Regulation Of Cell Proliferation Death Response To Stress Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Signal Transduction Response To Gamma Radiation Regulation Of Cell Differentiation Cytoskeleton Organization Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Response To Radiation Regulation Of Kinase Activity Negative Regulation Of Mitotic Cell Cycle Regulation Of Signaling Cell Aging Regulation Of Cell Cycle Phase Transition Regulation Of Phosphorylation Protein Phosphorylation Intracellular Signal Transduction Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Microtubule Polymerization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Activation Of Protein Kinase Activity
Tagcloud ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Difference) ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Intersection) ?