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EIF2AK2 and DHX58
Number of citations of the paper that reports this interaction (PMID
21903422
)
33
Data Source:
BioGRID
(pull down)
EIF2AK2
DHX58
Gene Name
eukaryotic translation initiation factor 2-alpha kinase 2
DEXH (Asp-Glu-X-His) box polypeptide 58
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Ribosome
Membrane
Perinuclear Region Of Cytoplasm
Cytoplasm
Molecular Function
Double-stranded RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Type 2A Regulator Activity
Poly(A) RNA Binding
DNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Biological Process
Activation Of MAPKK Activity
Positive Regulation Of Cytokine Production
Transcription, DNA-templated
Translation
Protein Phosphorylation
Negative Regulation Of Cell Proliferation
Response To Virus
Negative Regulation Of Translation
Peptidyl-tyrosine Phosphorylation
Modulation By Virus Of Host Morphology Or Physiology
Modulation By Virus Of Host Process
Viral Life Cycle
Evasion Or Tolerance By Virus Of Host Immune Response
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Chemokine Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Osteoblast Proliferation
Response To Interferon-alpha
Negative Regulation Of Apoptotic Process
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Hematopoietic Stem Cell Proliferation
Regulation Of Hematopoietic Stem Cell Differentiation
Metabolic Process
Response To Virus
Viral Process
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Negative Regulation Of MDA-5 Signaling Pathway
Negative Regulation Of RIG-I Signaling Pathway
Innate Immune Response
Regulation Of Innate Immune Response
Negative Regulation Of Innate Immune Response
Defense Response To Virus
Positive Regulation Of MDA-5 Signaling Pathway
Positive Regulation Of RIG-I Signaling Pathway
Pathways
ISG15 antiviral mechanism
Interferon Signaling
Inhibition of PKR
Cytokine Signaling in Immune system
Host Interactions with Influenza Factors
Influenza Infection
NS1 Mediated Effects on Host Pathways
Antiviral mechanism by IFN-stimulated genes
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
48 interactors:
CASP3
CASP7
CASP8
CDC42
CHUK
DHX30
DHX58
DHX9
DICER1
DNAJC3
EDC4
EIF2S1
EIF6
ELF2
FTSJ3
HIST2H2AC
HSP90AA1
HSPA1A
IKBKB
IL7R
ILF2
ILF3
JAK1
MAP3K5
MAP3K7
METAP2
MOV10
NFKBIA
NPM1
PDGFRB
PPP1CA
PPP1CC
PPP2R5A
PRKRA
PRKRIP1
PRKRIR
PTGES3
RAC1
STAT1
STAT3
STRBP
TAB2
TARBP2
TIRAP
TOLLIP
TP53
TYK2
ZNF346
9 interactors:
AGO2
AP2B1
APP
DHX30
DICER1
EIF2AK2
EIF6
NKRF
STAU2
Entrez ID
5610
79132
HPRD ID
01468
13115
Ensembl ID
ENSG00000055332
ENSG00000108771
Uniprot IDs
B7ZKK7
P19525
Q8IW76
Q96C10
PDB IDs
1QU6
2A19
2A1A
3UIU
2RQA
2W4R
3EQT
Enriched GO Terms of Interacting Partners
?
Immune Response
Defense Response
Immune System Process
Innate Immune Response
Response To Stress
Response To Organic Substance
Cellular Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Regulation Of Immune System Process
Regulation Of Immune Response
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Innate Immune Response
Positive Regulation Of Metabolic Process
Response To Stimulus
Regulation Of Cell Death
Response To External Stimulus
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Response To Stimulus
Regulation Of Apoptotic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Fc Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Signal Transduction
Toll-like Receptor 4 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Posttranscriptional Regulation Of Gene Expression
Cellular Response To Growth Factor Stimulus
Response To Biotic Stimulus
Response To Abiotic Stimulus
Signaling
Response To Growth Factor
Response To Virus
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Kinase Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Metabolic Process
Response To DsRNA
Positive Regulation Of Intracellular Signal Transduction
MyD88-independent Toll-like Receptor Signaling Pathway
RNA Interference
Pre-miRNA Processing
Posttranscriptional Regulation Of Gene Expression
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Ribonucleoprotein Complex Assembly
Regulation Of Defense Response To Virus By Virus
RNA Processing
Gene Expression
Gene Silencing By MiRNA
Cellular Response To DsRNA
Posttranscriptional Gene Silencing
Regulation Of Translation
Ribonucleoprotein Complex Biogenesis
Gene Silencing By RNA
Regulation Of Viral Genome Replication
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Regulation Of Translational Initiation
Response To DsRNA
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
RNA Metabolic Process
Evasion Or Tolerance By Virus Of Host Immune Response
Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference
Hair Follicle Cell Proliferation
Conversion Of Ds SiRNA To Ss SiRNA
Regulation Of ERBB Signaling Pathway
Regulation Of Defense Response To Virus
Negative Regulation Of Translation
Negative Regulation Of Cellular Metabolic Process
Immune System Process
Gene Silencing
RNA Phosphodiester Bond Hydrolysis
MRNA Cleavage Involved In Gene Silencing By MiRNA
Regulation Of Enamel Mineralization
Peripheral Nervous System Myelin Formation
Synaptic Growth At Neuromuscular Junction
Zygote Asymmetric Cell Division
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Gene Expression
Defense Response
Negative Regulation Of Biosynthetic Process
SiRNA Loading Onto RISC Involved In RNA Interference
Targeting Of MRNA For Destruction Involved In RNA Interference
Collateral Sprouting In Absence Of Injury
Evasion Or Tolerance Of Host Defenses By Virus
Notch Signaling Pathway
Post-embryonic Development
Cellular Macromolecular Complex Assembly
Regulation Of Viral Process
Neuron Projection Morphogenesis
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Tagcloud
?
c1qdc1
cds1
crebbp
ctnnd1
cul1
customized
dner
eef2
fzd2
fzd9
g93a
gastrocnemius
id2
inppl1
keep
loxl2
neuromuscular
pi3
pik3c2a
pik4ca
piki3r1
precede
presymptomatic
prkx
rac3
ripk4
snf1lk
sod1
tbl1x
Tagcloud (Difference)
?
c1qdc1
cds1
crebbp
ctnnd1
cul1
customized
dner
eef2
fzd2
fzd9
g93a
gastrocnemius
id2
inppl1
keep
loxl2
neuromuscular
pi3
pik3c2a
pik4ca
piki3r1
precede
presymptomatic
prkx
rac3
ripk4
snf1lk
sod1
tbl1x
Tagcloud (Intersection)
?