EIF2AK2 and ZNF346

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EIF2AK2	ZNF346
Gene Name		eukaryotic translation initiation factor 2-alpha kinase 2	zinc finger protein 346
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Type 2A Regulator Activity Poly(A) RNA Binding	Double-stranded RNA Binding Protein Binding Zinc Ion Binding Enzyme Binding Poly(A) RNA Binding
	Biological Process	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Transcription, DNA-templated Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Modulation By Virus Of Host Process Viral Life Cycle Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Positive Regulation Of Apoptotic Process
Pathways		ISG15 antiviral mechanism Interferon Signaling Inhibition of PKR Cytokine Signaling in Immune system Host Interactions with Influenza Factors Influenza Infection NS1 Mediated Effects on Host Pathways Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 HIST2H2AC HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PRKRIR PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 TIRAP TOLLIP TP53 TYK2 ZNF346	5 interactors: ANKHD1 EIF2AK2 ILF3 TARBP2 XPO5
Entrez ID		5610	23567
HPRD ID		01468	05606
Ensembl ID		ENSG00000055332	ENSG00000113761
Uniprot IDs		B7ZKK7 P19525 Q8IW76	B7Z367 B7Z4J8 D6RJ07 Q9UL40
PDB IDs		1QU6 2A19 2A1A 3UIU
Enriched GO Terms of Interacting Partners?		Immune Response Defense Response Immune System Process Innate Immune Response Response To Stress Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Response To Stimulus Regulation Of Cell Death Response To External Stimulus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Fc Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Signal Transduction Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posttranscriptional Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Biotic Stimulus Response To Abiotic Stimulus Signaling Response To Growth Factor Response To Virus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Response To DsRNA Positive Regulation Of Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway	Regulation Of Viral Genome Replication Regulation Of Viral Process Regulation Of Translation Negative Regulation Of Defense Response To Virus Negative Regulation Of Gene Expression Negative Regulation Of Viral Genome Replication Posttranscriptional Regulation Of Gene Expression Gene Silencing By RNA Negative Regulation Of Viral Process Regulation Of Defense Response To Virus Negative Regulation Of Translation Gene Silencing Negative Regulation Of Cellular Protein Metabolic Process Evasion Or Tolerance By Virus Of Host Immune Response Negative Regulation Of Protein Metabolic Process Defense Response To Virus Regulation Of Hematopoietic Stem Cell Differentiation MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Gene Expression Evasion Or Tolerance Of Host Defenses By Virus Targeting Of MRNA For Destruction Involved In RNA Interference Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Response To Virus Regulation Of Hematopoietic Stem Cell Proliferation Production Of SiRNA Involved In RNA Interference Response To Host Immune Response RNA Interference Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Immune System Process Pre-miRNA Processing Negative Regulation Of Defense Response To Virus By Host Regulation Of Translational Initiation In Response To Stress Regulation Of Gene Expression Negative Regulation Of Osteoblast Proliferation Regulation Of Cellular Protein Metabolic Process Modulation By Virus Of Host Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Cellular Metabolic Process Regulation Of Translation In Response To Stress Response To Interferon-alpha Regulation Of Protein Metabolic Process Positive Regulation Of Viral Genome Replication Modulation By Virus Of Host Morphology Or Physiology Regulation Of Osteoblast Proliferation Regulation Of Defense Response To Virus By Virus Gene Silencing By MiRNA Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Defense Response To Virus By Host Cellular Response To DsRNA Response To Other Organism
Tagcloud ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Difference) ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
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