EIF2AK2 and EIF6

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		EIF2AK2	EIF6
Description		eukaryotic translation initiation factor 2 alpha kinase 2	eukaryotic translation initiation factor 6
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Intermediate Filament Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Regulator Activity Identical Protein Binding Protein Serine Kinase Activity	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding
	Biological Process	Positive Regulation Of Cytokine Production Immune System Process Translation Translational Initiation Regulation Of Translational Initiation Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Translation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Antiviral Innate Immune Response Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translation Translational Initiation Response To Insulin MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Ribosome Biogenesis Cytosolic Ribosome Assembly Ribosomal Large Subunit Biogenesis Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		ISG15 antiviral mechanism Inhibition of PKR SUMOylation of immune response proteins Interferon alpha/beta signaling Evasion by RSV of host interferon responses PKR-mediated signaling
Drugs		Indomethacin H-89 Fostamatinib	Copper
Diseases
GWAS		Glucose homeostasis traits ( 25524916) Platelet count ( 32888494)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		131 interacting genes: ADARB1 CAPRIN1 CASP3 CASP7 CASP8 CDC42 CHUK DHX58 DICER1 DNAJC3 EDC4 EIF2A EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 LINC00624 MAP2K6 MAP3K5 MAP3K7 MAVS METAP2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NCK1 NEIL3 NFKBIA NPM1 OGT PA2G4 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 RPL18 SPIDR STAT1 STAT3 STRBP SUMO1 TAB2 TARBP2 THAP12 TIRAP TP53 TYK2 UBE2I ZNF346	41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26
Entrez ID		5610	3692
HPRD ID		01468	04221
Ensembl ID		ENSG00000055332	ENSG00000242372
Uniprot IDs		A0A7P0Z4M0 P19525 Q8IW76	P56537
PDB IDs		1QU6 2A19 2A1A 3UIU 6D3K 6D3L 7OBK 7OBL 8BI7 8I9J 8IZN	6LQM 6LSR 6LSS 6LU8 7OW7 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8OHD 8OJ0 8OJ8 8RL2 9GMO
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Translation Extracellular Vesicle Regulation Of Translation Negative Regulation Of Cytokine Production Negative Regulation Of Cell Migration Regulation Of Cytokine Production MRNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility RNA Destabilization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Motility Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Developmental Process	Calyx Of Held Identical Protein Binding Regulation Of Proteolysis Regulation Of Translation Negative Regulation Of Gene Expression Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Viral Life Cycle Translation Anaphase-promoting Complex Binding Negative Regulation Of Cell Size Regulation Of Vesicle-mediated Transport Positive Regulation Of Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Viral Process Mitotic Nuclear Membrane Disassembly Centriolar Satellite Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Protein Binding Post-transcriptional Regulation Of Gene Expression Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Chemokine Production G Protein-coupled Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Receptor Internalization Negative Regulation Of Viral Process Double-stranded RNA Binding Membrane Disassembly Spindle Organization Nuclear Membrane Disassembly Endoplasmic Reticulum Unfolded Protein Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Endocytosis Antiviral Innate Immune Response Postsynaptic Density Organization Negative Regulation Of Translation Protein Disulfide Isomerase Activity Ribosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?