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EIF2AK2 and METAP2
Number of citations of the paper that reports this interaction (PubMedID
11123929
)
0
Data Source:
HPRD
(in vivo, in vitro)
EIF2AK2
METAP2
Description
eukaryotic translation initiation factor 2 alpha kinase 2
methionyl aminopeptidase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Ribosome
Membrane
Perinuclear Region Of Cytoplasm
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
Nucleotide Binding
RNA Binding
Double-stranded RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Phosphatase Regulator Activity
Identical Protein Binding
Protein Serine Kinase Activity
RNA Binding
Aminopeptidase Activity
Initiator Methionyl Aminopeptidase Activity
Protein Binding
Peptidase Activity
Metalloexopeptidase Activity
Hydrolase Activity
Metal Ion Binding
Metalloaminopeptidase Activity
Biological Process
Positive Regulation Of Cytokine Production
Immune System Process
Translation
Translational Initiation
Regulation Of Translational Initiation
Protein Phosphorylation
Negative Regulation Of Cell Population Proliferation
Response To Virus
Negative Regulation Of Translation
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Chemokine Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Osteoblast Proliferation
Cellular Response To Amino Acid Starvation
Response To Interferon-alpha
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Antiviral Innate Immune Response
Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Hematopoietic Stem Cell Proliferation
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of Translational Initiation
Proteolysis
Protein Processing
Pathways
ISG15 antiviral mechanism
Inhibition of PKR
SUMOylation of immune response proteins
Interferon alpha/beta signaling
Evasion by RSV of host interferon responses
PKR-mediated signaling
Inactivation, recovery and regulation of the phototransduction cascade
Drugs
Indomethacin
H-89
Fostamatinib
Methionine
Nitroxoline
3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium
Fumagillin
D-Methionine
N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide
(2R,3R,4S,5R,6E)-3,4,5-Trihydroxy-N-[(3S,6R)-6-hydroxy-2-oxo-3-azepanyl]-2-methoxy-8,8-dimethyl-6-nonenamide
tert-butanol
(2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide
Ovalicin
PPI-2458
5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID
5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID
2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE
3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID
TNP-470
Diseases
GWAS
Glucose homeostasis traits (
25524916
)
Platelet count (
32888494
)
Blood protein levels (
30072576
)
C-reactive protein levels (
30388399
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
27863252
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Metabolite levels (
23823483
)
Reticulocyte count (
32888494
)
Interacting Genes
131 interacting genes:
ADARB1
CAPRIN1
CASP3
CASP7
CASP8
CDC42
CHUK
DHX58
DICER1
DNAJC3
EDC4
EIF2A
EIF2S1
EIF6
ELF2
FTSJ3
H2AC20
H2AC4
HSP90AA1
HSPA1A
IKBKB
IL7R
ILF2
ILF3
JAK1
LINC00624
MAP2K6
MAP3K5
MAP3K7
MAVS
METAP2
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NCK1
NEIL3
NFKBIA
NPM1
OGT
PA2G4
PDGFRB
PPP1CA
PPP1CC
PPP2R5A
PRKRA
PRKRIP1
PTGES3
RAC1
RPL18
SPIDR
STAT1
STAT3
STRBP
SUMO1
TAB2
TARBP2
THAP12
TIRAP
TP53
TYK2
UBE2I
ZNF346
16 interacting genes:
APP
CALM1
CDC42
CEBPA
DSCAM
EIF2AK2
EIF2S3
FBXL17
HMGA1
MAPK1
MAPK3
OGT
PJA1
RAC1
S100A4
YWHAE
Entrez ID
5610
10988
HPRD ID
01468
03522
Ensembl ID
ENSG00000055332
ENSG00000111142
Uniprot IDs
A0A7P0Z4M0
P19525
Q8IW76
A0A140VJE3
F8VQZ7
P50579
PDB IDs
1QU6
2A19
2A1A
3UIU
6D3K
6D3L
7OBK
7OBL
8BI7
8I9J
8IZN
1B59
1B6A
1BN5
1BOA
1KQ0
1KQ9
1QZY
1R58
1R5G
1R5H
1YW7
1YW8
1YW9
2ADU
2EA2
2EA4
2GA2
2OAZ
5CLS
5D6E
5D6F
5JFR
5JHU
5JI6
5LYW
5LYX
6QED
6QEF
6QEG
6QEH
6QEI
6QEJ
7A12
7A13
7A14
7A15
7A16
8ONY
8OXG
9FPZ
Enriched GO Terms of Interacting Partners
?
RISC Complex
MiRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
MRNA 3'-UTR Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Regulation Of Metabolic Process
Negative Regulation Of Translation
Extracellular Vesicle
Regulation Of Translation
Negative Regulation Of Cytokine Production
Negative Regulation Of Cell Migration
Regulation Of Cytokine Production
MRNA Destabilization
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Cell Motility
RNA Destabilization
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Locomotion
Regulation Of Angiogenesis
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Regulation Of Vasculature Development
Negative Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of MRNA Metabolic Process
Regulation Of MRNA Stability
Regulation Of Cell Migration
Regulation Of RNA Stability
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Cell Motility
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Locomotion
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Developmental Process
Intracellular Signal Transduction
Positive Regulation Of Chemotaxis
Intracellular Signaling Cassette
Response To Peptide
Response To Cytokine
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Chemotaxis
Positive Regulation Of Leukocyte Chemotaxis
Focal Adhesion
Endocytosis
Regulation Of Intracellular Signal Transduction
Interleukin-34-mediated Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Stress-activated MAPK Cascade
Regulation Of Golgi Inheritance
Regulation Of Stress-activated Protein Kinase Signaling Cascade
Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Caveolin-mediated Endocytosis
Positive Regulation Of Macrophage Proliferation
Regulation Of Signal Transduction
Positive Regulation Of Leukocyte Migration
Substantia Nigra Development
Positive Regulation Of Locomotion
Regulation Of Calcium Ion Export Across Plasma Membrane
Import Into Cell
Regulation Of Granulocyte Chemotaxis
Positive Regulation Of Inflammatory Response
G Protein-coupled Receptor Signaling Pathway Involved In Heart Process
Cardiac Neural Crest Cell Development Involved In Heart Development
Trachea Formation
Regulation Of MAPK Cascade
Cell Surface Receptor Signaling Pathway
Regulation Of Locomotion
Glial Cell Development
Neural Nucleus Development
Cellular Response To Amino Acid Starvation
Outer Ear Morphogenesis
ERBB3 Signaling Pathway
ERBB2-ERBB3 Signaling Pathway
Response To Amino Acid Starvation
Cellular Response To Cytokine Stimulus
Regulation Of Synaptic Plasticity
Regulation Of Cell Communication
Regulation Of Signaling
Signal Transduction
Thioesterase Binding
Bergmann Glial Cell Differentiation
Vesicle-mediated Transport
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Tagcloud (Difference)
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Tagcloud (Intersection)
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