EIF2AK2 and MIR9-3

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		EIF2AK2	MIR9-3
Description		eukaryotic translation initiation factor 2 alpha kinase 2	microRNA 9-3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	RISC Complex
	Molecular Function	Nucleotide Binding RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Regulator Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Cytokine Production Immune System Process Translation Translational Initiation Regulation Of Translational Initiation Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Translation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Antiviral Innate Immune Response Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		ISG15 antiviral mechanism Inhibition of PKR SUMOylation of immune response proteins Interferon alpha/beta signaling Evasion by RSV of host interferon responses PKR-mediated signaling
Drugs		Indomethacin H-89 Fostamatinib
Diseases
GWAS		Glucose homeostasis traits ( 25524916) Platelet count ( 32888494)	Schizophrenia ( 28991256 30285260)
Interacting Genes		131 interacting genes: ADARB1 CAPRIN1 CASP3 CASP7 CASP8 CDC42 CHUK DHX58 DICER1 DNAJC3 EDC4 EIF2A EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 LINC00624 MAP2K6 MAP3K5 MAP3K7 MAVS METAP2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NCK1 NEIL3 NFKBIA NPM1 OGT PA2G4 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 RPL18 SPIDR STAT1 STAT3 STRBP SUMO1 TAB2 TARBP2 THAP12 TIRAP TP53 TYK2 UBE2I ZNF346	66 interacting genes: ADARB1 APOBEC3B CRTAP DARS1 DDX1 DDX21 DDX3X EIF2AK2 EPRS1 ERAL1 FAM98A FIP1L1 FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LRPPRC MARS1 MATR3 MSI2 NONO P3H1 PDCD11 PRMT1 PTBP1 PUF60 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SF3B1 SF3B3 SFPQ STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2B UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A
Entrez ID		5610	407051
HPRD ID		01468
Ensembl ID		ENSG00000055332	ENSG00000284329
Uniprot IDs		A0A7P0Z4M0 P19525 Q8IW76
PDB IDs		1QU6 2A19 2A1A 3UIU 6D3K 6D3L 7OBK 7OBL 8BI7 8I9J 8IZN
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Translation Extracellular Vesicle Regulation Of Translation Negative Regulation Of Cytokine Production Negative Regulation Of Cell Migration Regulation Of Cytokine Production MRNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility RNA Destabilization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Motility Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Developmental Process	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Ribonucleoprotein Complex Macromolecule Metabolic Process MRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleoplasm MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleus Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Catalytic Step 2 Spliceosome Spliceosomal Complex Negative Regulation Of MRNA Catabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process MiRNA Binding Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of RNA Catabolic Process TRNA Aminoacylation MRNA Stabilization Regulation Of MRNA Processing Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Stabilization Regulation Of Metabolic Process Cytoplasmic Stress Granule Negative Regulation Of Macromolecule Metabolic Process TRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Alternative MRNA Splicing, Via Spliceosome CRD-mediated MRNA Stabilization Regulation Of RNA Stability Negative Regulation Of Metabolic Process Ligase Activity Negative Regulation Of Translation
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