MAPKAPK5 and LSR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MAPKAPK5	LSR
Description		MAPK activated protein kinase 5	lipolysis stimulated lipoprotein receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Plasma Membrane Bicellular Tight Junction Membrane Cell Junction Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Chylomicron Tricellular Tight Junction Extracellular Exosome Tight Junction Anchoring Junction
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Dendritic Spine Development Cellular Senescence Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction	Liver Development Epithelial Structure Maintenance Maintenance Of Blood-brain Barrier Establishment Of Blood-brain Barrier Establishment Of Skin Barrier Protein Localization To Tricellular Tight Junction Tricellular Tight Junction Assembly
Pathways		Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation	LDL clearance VLDL clearance
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Spleen volume ( 34128465) Tea consumption ( 33080986)	Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) Red blood cell count ( 27863252)
Interacting Genes		32 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HMGB1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SNCA SRPK1 SRPK2 TAB1 TP53 YAP1 ZNF282 ZNF576	4 interacting genes: MAPKAPK5 OGT RARG YWHAG
Entrez ID		8550	51599
HPRD ID		09467	17283
Ensembl ID		ENSG00000089022	ENSG00000105699
Uniprot IDs		Q8IW41	A0A8Z5AA41 A0A8Z5DL71 Q86X29 S4R3V8
PDB IDs
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Cellular Response To Anisomycin Cytosol Kinase Activity Positive Regulation Of Cytokine Production Response To Anisomycin Nucleus Stress-activated MAPK Cascade Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Response To Stress Cellular Response To Stress Phosphorylation Cytoplasm Animal Organ Development Regulation Of Gene Expression Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Phosphate-containing Compound Metabolic Process Protein Localization To Tricellular Tight Junction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process ATP Binding Positive Regulation Of Biosynthetic Process Cellular Senescence Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia P38MAPK Cascade Cellular Response To Radiation Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Postsynapse Cellular Response To Oxygen-containing Compound Cellular Response To UV RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Apoptotic Process Transferase Activity Nucleotide Binding Cellular Response To Oxidative Stress Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Response To Oxidative Stress	Regulation Of TOR Signaling Protein Localization To Lysosome Positive Regulation Of TORC1 Signaling Negative Regulation Of Translational Initiation Regulation Of Translation Positive Regulation Of Translational Initiation TORC1 Signaling Intracellular Signal Transduction Post-transcriptional Regulation Of Gene Expression Positive Regulation Of TOR Signaling Protein Localization To Vacuole Negative Regulation Of TOR Signaling TOR Signaling Regulation Of Translational Initiation Regulation Of TORC1 Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cytoplasmic Translation Regulation Of Developmental Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Translation Septin Cytoskeleton Response To Insulin Positive Regulation Of Biosynthetic Process Growth Plate Cartilage Chondrocyte Growth Negative Regulation Of Translation Protein Kinase C Inhibitor Activity Protein O-acetylglucosaminyltransferase Activity Trachea Cartilage Development Harderian Gland Development Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Glandular Epithelial Cell Development Chondrocyte Hypertrophy Negative Regulation Of Multicellular Organismal Process Cellular Response To Nutrient Levels Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Calcium-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Carbon Catabolite Regulation Of Transcription Stress-induced Premature Senescence Response To Peptide Hormone Negative Regulation Of Signal Transduction Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Transcription By Glucose
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