MAPKAPK5 and EIF4EBP1

Number of citations of the paper that reports this interaction (PubMedID 9628874)
68

Data Source:
HPRD (in vitro)

		MAPKAPK5	EIF4EBP1
Description		MAPK activated protein kinase 5	eukaryotic translation initiation factor 4E binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Translation Initiation Factor Binding
	Biological Process	MAPK Cascade Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Dendritic Spine Development Cellular Senescence Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction	G1/S Transition Of Mitotic Cell Cycle Regulation Of Translation Negative Regulation Of Translation TOR Signaling Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation
Pathways		Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation	mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Spleen volume ( 34128465) Tea consumption ( 33080986)	Menopause (age at onset) ( 29773799)
Interacting Genes		32 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HMGB1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SNCA SRPK1 SRPK2 TAB1 TP53 YAP1 ZNF282 ZNF576	38 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD PICK1 POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655
Entrez ID		8550	1978
HPRD ID		09467	03746
Ensembl ID		ENSG00000089022	ENSG00000187840
Uniprot IDs		Q8IW41	Q13541
PDB IDs			1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX 8RCH 8RCK 8RCN
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Cellular Response To Anisomycin Cytosol Kinase Activity Positive Regulation Of Cytokine Production Response To Anisomycin Nucleus Stress-activated MAPK Cascade Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Response To Stress Cellular Response To Stress Phosphorylation Cytoplasm Animal Organ Development Regulation Of Gene Expression Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Phosphate-containing Compound Metabolic Process Protein Localization To Tricellular Tight Junction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process ATP Binding Positive Regulation Of Biosynthetic Process Cellular Senescence Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia P38MAPK Cascade Cellular Response To Radiation Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Postsynapse Cellular Response To Oxygen-containing Compound Cellular Response To UV RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Apoptotic Process Transferase Activity Nucleotide Binding Cellular Response To Oxidative Stress Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Response To Oxidative Stress	Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Phosphorylation ATP Binding Phosphorylation TOR Signaling Nucleotide Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Intracellular Signaling Cassette Negative Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Translation Regulation Of Gene Expression TORC2 Signaling Positive Regulation Of Cellular Component Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Growth Regulation Of Signal Transduction Post-transcriptional Regulation Of Gene Expression Regulation Of Autophagy Negative Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Cycle Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Transferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Autophagy Positive Regulation Of Growth Cellular Response To Nutrient Levels TORC1 Signaling Response To Nutrient Levels Protein Metabolic Process Regulation Of TORC2 Signaling Positive Regulation Of Protein-containing Complex Assembly
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