MASP1 and NCK2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MASP1	NCK2
Gene Name		mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	NCK adaptor protein 2
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding	SH3/SH2 Adaptor Activity Protein Binding Cytoskeletal Adaptor Activity Receptor Signaling Complex Scaffold Activity
	Biological Process	Complement Activation, Lectin Pathway Proteolysis Receptor-mediated Endocytosis Complement Activation Innate Immune Response Negative Regulation Of Complement Activation	Regulation Of Translation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways		Creation of C4 and C2 activators Complement cascade Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors Initial triggering of complement Lectin pathway of complement activation Innate Immune System	Signaling by PDGF Ephrin signaling Axon guidance Activation of Rac Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling Nephrin interactions Signaling by Robo receptor VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Addiction ( 23533358)
Protein-Protein Interactions		15 interactors: C2 C3 FCN2 GADD45A GSK3B H2AFX MAPK6 MAPK8IP2 MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1L	80 interactors: ABI1 ABI2 ABI3 ARHGAP32 ATN1 AXIN1 AXL BCL11A CBLB CCDC33 CD3E CHN1 CPSF6 CPSF7 DDR1 DNM1 DOCK1 DOK1 DRAP1 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EGFR EIF3H ERBB2 ERBB3 FAM53C FASLG FCRL2 FGFR1 FXR2 HNRNPK HOMEZ HOXC4 ILK IRS1 KHDRBS1 KIAA1217 LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MEOX2 NCKIPSD NPHS1 NR5A1 NTRK2 PAK1 PDGFRB PKN2 PRR20A PSMD10 PTK2 RASSF7 RBM26 REL SF3B4 SORBS2 SOS1 SPRY2 SRPK1 SRPK2 SYNPO TCF4 TNR TRIM27 TRIM41 TRIP6 VARS2 VPS37B WAS WASL WBP11 WIPF2 ZBTB7B
Entrez ID		5648	8440
HPRD ID		02749	05378
Ensembl ID		ENSG00000127241	ENSG00000071051
Uniprot IDs		P48740	E7ERP6 O43639
PDB IDs		3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD	1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?		Complement Activation Protein Activation Cascade Humoral Immune Response Innate Immune Response Regulation Of Immune System Process Regulation Of Immune Response Defense Response Response To Stress Positive Regulation Of Immune System Process Regulation Of Complement Activation Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Immune Response Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Response To External Stimulus Negative Regulation Of Cellular Protein Metabolic Process Immune Response Regulation Of Phagocytosis Positive Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Acute Inflammatory Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immune System Process Regulation Of Protein Metabolic Process Leukocyte Mediated Immunity Opsonization Regulation Of Apoptotic Cell Clearance Adaptive Immune Response Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Signal Complex Assembly Positive Regulation Of Endocytosis Response To Stimulus Cell Morphogenesis Involved In Differentiation Axon Guidance Negative Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Processing Neuron Projection Development Cell Projection Morphogenesis Negative Regulation Of Cellular Metabolic Process Cell Part Morphogenesis Regulation Of Phosphorus Metabolic Process Cellular Response To Stress	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Signaling Movement Of Cell Or Subcellular Component Cell Communication Immune Response Locomotion Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Peptidyl-tyrosine Phosphorylation Axon Guidance Intracellular Signal Transduction Cell Migration Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Anatomical Structure Development Positive Regulation Of Protein Metabolic Process Cell Development Gene Expression Regulation Of Cellular Process Immune System Process Cell Motility System Development Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Multicellular Organismal Development Chemotaxis Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Protein Metabolic Process Neuron Projection Morphogenesis Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Axon Development Developmental Process Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development
Tagcloud ?		accessibility adding attribute biocompatibility biodegradability bioengineered biomaterial clavipes combines desired doxorubicin enabling engineering functionalization functionalized h2 hybrids impede internalized loaded ms1 reasonable silk silks sphere spheres spider tag unless	accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Difference) ?		accessibility adding attribute biocompatibility biodegradability bioengineered biomaterial clavipes combines desired doxorubicin enabling engineering functionalization functionalized h2 hybrids impede internalized loaded ms1 reasonable silk silks sphere spheres spider tag unless	accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Intersection) ?