MASP1 and FCN2

Number of citations of the paper that reports this interaction (PubMedID 12421953)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MASP1	FCN2
Description		MBL associated serine protease 1	ficolin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol Symbiont Cell Surface	Extracellular Region Collagen Trimer Extracellular Space External Side Of Plasma Membrane Extracellular Matrix Extracellular Exosome Blood Microparticle Symbiont Cell Surface Serine-type Endopeptidase Complex
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding	Antigen Binding Signaling Receptor Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Proteoglycan Binding Metal Ion Binding Calcium-dependent Protein Binding Lipoteichoic Acid Immune Receptor Activity Carbohydrate Derivative Binding Mannan Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Negative Regulation Of Complement Activation Protein Maturation	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Complement Activation Opsonization Zymogen Activation Killing Of Cells Of Another Organism Recognition Of Apoptotic Cell Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Maturation Positive Regulation Of Opsonization
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors SARS-CoV-2 activates/modulates innate and adaptive immune responses	Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)	Blood protein levels ( 30072576)
Interacting Genes		16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1	2 interacting genes: MASP1 MASP2
Entrez ID		5648	2220
HPRD ID		02749	03376
Ensembl ID		ENSG00000127241	ENSG00000160339
Uniprot IDs		P48740	Q15485
PDB IDs		3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD 7PQO	2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Complement Activation Positive Regulation Of Phagocytosis Response To Stress Regulation Of Phagocytosis Classical-complement-pathway C3/C5 Convertase Complex Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Regulation Of Immune Response Positive Regulation Of Endocytosis Ribosomal Protein S6 Kinase Activity Cell Killing Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Opsonization Signal Complex Assembly Activation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Cellular Component Organization Regulation Of Apoptotic Cell Clearance Regulation Of Opsonization Serine-type Endopeptidase Complex Regulation Of Innate Immune Response Protein Kinase Binding Complement Activation, GZMK Pathway TOR Signaling Regulation Of Defense Response Humoral Immune Response Regulation Of Cellular Response To Heat Dynactin Binding Regulation Of Cellular Response To Stress Regulation Of Endocytosis Protein Maturation Blood Microparticle Regulation Of Translation In Response To Stress Regulation Of Complement Activation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Signal Transduction Immune Response-activating Signaling Pathway Protein Serine Kinase Activity Cellular Response To Stress Signal Transduction In Response To DNA Damage Immune Effector Process Protein Metabolic Process Protein Serine/threonine Kinase Activity Response To Bacterium Regulation Of Multicellular Organismal Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Zymogen Activation Complement Activation Calcium-dependent Protein Binding Serine-type Peptidase Activity Killing Of Cells Of Another Organism Serine-type Endopeptidase Activity Protein Processing Cell Killing Humoral Immune Response Complement Component C4b Binding Protein Maturation Immune Effector Process Activation Of Immune Response Peptidase Activity Calcium Ion Binding Innate Immune Response Positive Regulation Of Immune Response Negative Regulation Of Complement Activation Complement Activation, Alternative Pathway Defense Response To Symbiont Defense Response To Other Organism Regulation Of Complement Activation Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Other Organism Complement Activation, Classical Pathway Immune Response Proteolysis Regulation Of Humoral Immune Response Response To External Biotic Stimulus Defense Response Extracellular Space Hydrolase Activity Regulation Of Immune System Process Identical Protein Binding Immune System Process Extracellular Region Negative Regulation Of Immune Response Protein Metabolic Process Response To Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?