PRKAB1 and NDUFA7

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRKAB1	NDUFA7
Gene Name		protein kinase, AMP-activated, beta 1 non-catalytic subunit	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol AMP-activated Protein Kinase Complex	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function	Protein Kinase Activity AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding	NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Protein Kinase Activity Protein Heterooligomerization Membrane Organization	Mitochondrial Electron Transport, NADH To Ubiquinone Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs		Adenosine monophosphate Metformin	NADH
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3	5 interactors: ELAC2 MDFI PRKAB1 STARD9 UPF2
Entrez ID		5564	4701
HPRD ID		04116	11885
Ensembl ID		ENSG00000111725	ENSG00000267855
Uniprot IDs		Q9Y478	O95182
PDB IDs
Enriched GO Terms of Interacting Partners?		Fatty Acid Biosynthetic Process Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Regulation Of Glycolytic Process Response To Insulin Energy Derivation By Oxidation Of Organic Compounds Energy Reserve Metabolic Process Cellular Response To Peptide Hormone Stimulus Carnitine Shuttle Fatty Acid Metabolic Process Cellular Response To Peptide Cell Cycle Arrest Carnitine Transmembrane Transport Carnitine Transport Generation Of Precursor Metabolites And Energy Phosphorylation Regulation Of Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Protein Phosphorylation Response To Peptide Quaternary Ammonium Group Transport Phosphate-containing Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Small Molecule Metabolic Process Sterol Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Carbohydrate Metabolic Process Long-chain Fatty Acid Transport Ammonium Transmembrane Transport Sterol Biosynthetic Process Lipid Metabolic Process Response To Organonitrogen Compound Negative Regulation Of Cell Cycle Glycogen Metabolic Process Fatty Acid Transport Regulation Of Cell Cycle Oxidation-reduction Process Cellular Lipid Metabolic Process Cellular Protein Modification Process Ammonium Transport Steroid Metabolic Process Carboxylic Acid Metabolic Process Polysaccharide Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process	Mitochondrial TRNA 3'-trailer Cleavage, Endonucleolytic TRNA 3'-trailer Cleavage Mitochondrial RNA 3'-end Processing TRNA 3'-end Processing
Tagcloud ?		adipor1 alter amp bdkrb2 changed differential discordant epigenome exercise fh hoxc6 mapk1 mef2a methylation modifies monozygotic muscle myo18b ndufc2 pairs predispose retinol runx1 skeletal t2d thada trib1 twin twins
Tagcloud (Difference) ?		adipor1 alter amp bdkrb2 changed differential discordant epigenome exercise fh hoxc6 mapk1 mef2a methylation modifies monozygotic muscle myo18b ndufc2 pairs predispose retinol runx1 skeletal t2d thada trib1 twin twins
Tagcloud (Intersection) ?