PRKAB1 and AGL

Number of citations of the paper that reports this interaction (PubMedID 15886229)
0

Data Source:
HPRD (in vitro, in vivo)

		PRKAB1	AGL
Description		protein kinase AMP-activated non-catalytic subunit beta 1	amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex Protein-containing Complex	Extracellular Region Nucleus Cytoplasm Cytosol Inclusion Body Sarcoplasmic Reticulum Secretory Granule Lumen Isoamylase Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Protein Kinase Binding	Catalytic Activity 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Polysaccharide Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Cellular Response To Nutrient Levels Nail Development Positive Regulation Of Cold-induced Thermogenesis	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Glycogen Catabolic Process Response To Nutrient Response To Hormone Response To Glucocorticoid
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Adenosine phosphate Adenosine phosphate Metformin Acetylsalicylic acid Fostamatinib
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Basophil count ( 32888494) Inflammatory bowel disease ( 26192919) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Ulcerative colitis ( 26192919) White blood cell count ( 32888494)	Carotid intima media thickness ( 26343869) Incident chronic kidney disease ( 30955190) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		13 interacting genes: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2 SLC31A1	3 interacting genes: APPL1 NHLRC1 PRKAB1
Entrez ID		5564	178
HPRD ID		04116	01984
Ensembl ID		ENSG00000111725	ENSG00000162688
Uniprot IDs		Q9Y478	A0A0S2A4E4 P35573
PDB IDs		4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6C9F 6C9G 6C9H 6C9J 7MYJ 8BIK
Enriched GO Terms of Interacting Partners?		AMP-activated Protein Kinase Activity Nucleotide-activated Protein Kinase Complex Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Fatty Acid Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Glucose Starvation Positive Regulation Of Small Molecule Metabolic Process Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Glycolytic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Cellular Response To Prostaglandin Stimulus Carboxylic Acid Biosynthetic Process Response To Prostaglandin E Phosphate-containing Compound Metabolic Process Regulation Of Carbon Utilization Fatty Acid Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Small Molecule Metabolic Process Protein Localization To Lipid Droplet Sterol Biosynthetic Process Negative Regulation Of Tubulin Deacetylation CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Cellular Response To Starvation Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly CAMP-dependent Protein Kinase Regulator Activity Small Molecule Biosynthetic Process Protein Kinase Binding Monocarboxylic Acid Metabolic Process Response To Starvation Response To Nutrient Levels Phosphatidylethanolamine Biosynthetic Process ATP Binding Organophosphate Biosynthetic Process Lipid Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Cellular Response To Nutrient Levels Steroid Biosynthetic Process AMP Binding Positive Regulation Of TOR Signaling Response To Hormone Intracellular Copper Ion Homeostasis Protein Kinase Regulator Activity	Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Protein Localization To Membrane Macropinosome Nucleotide-activated Protein Kinase Complex Nail Development Response To Hepatocyte Growth Factor Regulation Of Melanin Biosynthetic Process Positive Regulation Of Pinocytosis Early Phagosome Regulation Of Cellular Localization Positive Regulation Of Melanin Biosynthetic Process Cellular Response To Hepatocyte Growth Factor Stimulus Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Adiponectin-activated Signaling Pathway Glycogen Biosynthetic Process Intracellular Vesicle Negative Regulation Of Phagocytosis Polysaccharide Biosynthetic Process Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of D-glucose Import Vesicle Membrane
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