MZB1 and CASP2

Number of citations of the paper that reports this interaction (PubMedID 11972030)
46

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MZB1	CASP2
Description		marginal zone B and B1 cell specific protein	caspase 2
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex	Nucleus Nucleolus Cytoplasm Cytosol Endopeptidase Complex
	Molecular Function	Protein Binding	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Apoptotic Process Positive Regulation Of Cell Population Proliferation Regulation Of B Cell Proliferation Integrin Activation Regulation Of Cell Population Proliferation Regulation Of Insulin Receptor Signaling Pathway	Luteolysis Neural Retina Development Proteolysis Apoptotic Process DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing DNA Damage Response, Signal Transduction By P53 Class Mediator Ectopic Germ Cell Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Protein Maturation Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway
Pathways			NOD1/2 Signaling Pathway NADE modulates death signalling TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Malaria ( 31844061)
Interacting Genes		4 interacting genes: CASP2 CASP9 MAPK6 TSG101	32 interacting genes: ADCYAP1 BAG4 BID CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MAPT MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 PRKAB2 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I
Entrez ID		51237	835
HPRD ID		17815	02800
Ensembl ID		ENSG00000170476	ENSG00000106144
Uniprot IDs		B3KQ72 Q8WU39	A0A087WYM1 A0A0S2Z3H1 P42575
PDB IDs		7AAH	1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM 6GKF 6GKG 6S9K 6SAD 6Y8B 6Y8D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity Intrinsic Apoptotic Signaling Pathway Signal Transduction In Response To DNA Damage Protein Processing Endopeptidase Complex Apoptosome Caspase Complex Septin Cytoskeleton Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Protein Metabolic Process Exosomal Secretion Luteolysis Regulation Of Neuron Apoptotic Process Proteolysis Response To Anesthetic Glial Cell Apoptotic Process Response To Indole-3-methanol Regulation Of Extracellular Exosome Assembly Protein Maturation Apoptotic Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Cobalt Ion Virion Binding Fibroblast Apoptotic Process ESCRT I Complex Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Exosomal Secretion Ectopic Germ Cell Programmed Cell Death Peptidase Activity Neural Retina Development Intracellular Signal Transduction Protein Kinase Binding MAP Kinase Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Exosomal Secretion Negative Regulation Of Peptidyl-tyrosine Phosphorylation Programmed Cell Death Involved In Cell Development Positive Regulation Of Execution Phase Of Apoptosis Viral Budding Via Host ESCRT Complex Regulation Of Protein Tyrosine Kinase Activity Platelet Formation Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Macromolecule Metabolic Process Execution Phase Of Apoptosis	Death Receptor Binding Cell Death Programmed Cell Death Apoptotic Process Cytosol Cytoplasm Regulation Of Apoptotic Process Execution Phase Of Apoptosis Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death Effector Domain Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Apoptotic Signaling Pathway Ripoptosome CD95 Death-inducing Signaling Complex Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death-inducing Signaling Complex Signal Transduction In Response To DNA Damage Positive Regulation Of Pyroptotic Inflammatory Response Regulation Of Multicellular Organismal Process Ubiquitin Protein Ligase Binding Pyroptotic Inflammatory Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Nucleus Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Proteolysis Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Enzyme Binding Intracellular Signal Transduction DNA Damage Response Response To Stress Endopeptidase Complex Regulation Of Protein-containing Complex Assembly Positive Regulation Of Signal Transduction Positive Regulation Of Protein Polymerization Cellular Response To Staurosporine Regulation Of Metabolic Process
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