PSIP1 and HMGA1

Number of citations of the paper that reports this interaction (PMID 18850631)
2

Data Source:
BioGRID (far western blotting, pull down)

		PSIP1	HMGA1
Gene Name		PC4 and SFRS1 interacting protein 1	high mobility group AT-hook 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Heterochromatin Nucleolus Cytosol Nuclear Periphery Transcriptionally Active Chromatin	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Focal Adhesion Senescence-associated Heterochromatin Focus
	Molecular Function	RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Protein Binding Activating Transcription Factor Binding Poly(A) RNA Binding Supercoiled DNA Binding	DNA Binding AT DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	MRNA 5'-splice Site Recognition Transcription, DNA-templated Regulation Of Transcription, DNA-templated Response To Oxidative Stress Response To Heat Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Integrated Proviral Latency	DNA Catabolic Process, Endonucleolytic DNA Unwinding Involved In DNA Replication Base-excision Repair Nucleosome Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Negative Regulation Of Cell Proliferation Response To Virus Viral Process Negative Regulation Of Chromatin Silencing Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Establishment Of Integrated Proviral Latency Oncogene-induced Cell Senescence Positive Regulation Of Cellular Senescence
Pathways		Autointegration results in viral DNA circles HIV Life Cycle Vpr-mediated nuclear import of PICs HIV Infection Host Interactions of HIV factors Integration of provirus 2-LTR circle formation Interactions of Vpr with host cellular proteins Integration of viral DNA into host genomic DNA APOBEC3G mediated resistance to HIV-1 infection Early Phase of HIV Life Cycle	DNA Damage/Telomere Stress Induced Senescence Vpr-mediated nuclear import of PICs HIV Infection Cellular Senescence Host Interactions of HIV factors Integration of provirus Interactions of Vpr with host cellular proteins Early Phase of HIV Life Cycle Autointegration results in viral DNA circles HIV Life Cycle Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2-LTR circle formation Integration of viral DNA into host genomic DNA APOBEC3G mediated resistance to HIV-1 infection
Drugs
Diseases
GWAS			Body mass index ( 20935630) Height ( 21998595 20881960 19396169 19343178 19893584 23563607 18391951 20397748 20189936)
Protein-Protein Interactions		10 interactors: CASP3 CASP7 CSNK2A1 HCFC1 HMGA1 HMGA2 MAPK6 SP1 SRSF1 SUB1	60 interactors: ANXA1 ANXA2 APEX1 ATF2 CDK1 CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EWSR1 GTF2F2 HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HSPA1A IRF1 JUN KAT2B METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PARP1 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RCC1 RN7SK RNF4 RXRA SP1 SRF SSB SUFU SYNCRIP UPF2
Entrez ID		11168	3159
HPRD ID		04688	02829
Ensembl ID		ENSG00000164985	ENSG00000137309
Uniprot IDs		O75475	P17096 Q5T6U8
PDB IDs		1Z9E 2B4J 2M16 3F9K 3HPG 3HPH 3U88 3ZEH 4FU6	2EZD 2EZE 2EZF 2EZG
Enriched GO Terms of Interacting Partners?		Oncogene-induced Cell Senescence Senescence-associated Heterochromatin Focus Assembly Positive Regulation Of Cellular Senescence Positive Regulation Of Cell Aging Positive Regulation Of Metabolic Process DNA Catabolic Process, Endonucleolytic Transcription, DNA-templated RNA Biosynthetic Process Heterochromatin Assembly Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Heterochromatin Organization DNA Catabolic Process Regulation Of Cellular Senescence Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Cellular Senescence Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Heterocycle Metabolic Process Interaction With Symbiont Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Base-excision Repair Regulation Of Viral Transcription Regulation Of Cell Cycle Cell Aging Execution Phase Of Apoptosis Positive Regulation Of Cellular Response To X-ray Sequestering Of Nodal From Receptor Via Nodal Binding Mesodermal-endodermal Cell Signaling Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Histone H2A-S139 Phosphorylation Chromosome Breakage Regulation Of Transcription, DNA-templated Regulation Of Endopeptidase Activity Regulation Of Nucleic Acid-templated Transcription	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Gene Expression Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Gene Expression RNA Splicing Biosynthetic Process Negative Regulation Of Transcription, DNA-templated RNA Processing Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Regulation Of Cell Cycle Viral Process Cell Differentiation Metabolic Process DNA-templated Transcription, Initiation Cellular Response To Organic Substance Developmental Process Regulation Of Cell Differentiation
Tagcloud ?		aggressive arid1a arise carcinoids copy covalent drive exome far inactivation lung men1 modifiers mutated neuroendocrine observe perform progenitor pulmonary rare rb1 recurrently remodelling snf swi systematically tp53 transcriptome tumours	arresting attribute augments bcl2 concomitantly e2 e6 evidences g0 galactosidase hmgb1 hpv16 htert kb linking mechanistic messaging papilloma re senescence senescent sensitizes shifted siha survivin sustaining tendency tnf tumorigenesis
Tagcloud (Difference) ?		aggressive arid1a arise carcinoids copy covalent drive exome far inactivation lung men1 modifiers mutated neuroendocrine observe perform progenitor pulmonary rare rb1 recurrently remodelling snf swi systematically tp53 transcriptome tumours	arresting attribute augments bcl2 concomitantly e2 e6 evidences g0 galactosidase hmgb1 hpv16 htert kb linking mechanistic messaging papilloma re senescence senescent sensitizes shifted siha survivin sustaining tendency tnf tumorigenesis
Tagcloud (Intersection) ?