PSIP1 and CASP7

Number of citations of the paper that reports this interaction (PMID 12181742)
19

Data Source:
HPRD (in vitro)

		PSIP1	CASP7
Gene Name		PC4 and SFRS1 interacting protein 1	caspase 7, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Heterochromatin Nucleolus Cytosol Nuclear Periphery Transcriptionally Active Chromatin	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Protein Binding Activating Transcription Factor Binding Poly(A) RNA Binding Supercoiled DNA Binding	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	MRNA 5'-splice Site Recognition Transcription, DNA-templated Regulation Of Transcription, DNA-templated Response To Oxidative Stress Response To Heat Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Integrated Proviral Latency	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		Autointegration results in viral DNA circles HIV Life Cycle Vpr-mediated nuclear import of PICs HIV Infection Host Interactions of HIV factors Integration of provirus 2-LTR circle formation Interactions of Vpr with host cellular proteins Integration of viral DNA into host genomic DNA APOBEC3G mediated resistance to HIV-1 infection Early Phase of HIV Life Cycle	Activation of caspases through apoptosome-mediated cleavage Apoptotic cleavage of cellular proteins Apoptotic factor-mediated response SMAC binds to IAPs Apoptotic execution phase Programmed Cell Death SMAC-mediated dissociation of IAP:caspase complexes Cytochrome c-mediated apoptotic response SMAC-mediated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins Intrinsic Pathway for Apoptosis
Drugs			Fica
Diseases
GWAS			Vitiligo ( 22561518)
Protein-Protein Interactions		10 interactors: CASP3 CASP7 CSNK2A1 HCFC1 HMGA1 HMGA2 MAPK6 SP1 SRSF1 SUB1	60 interactors: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAPT MAX MEF2A MEF2D NEDD4 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP
Entrez ID		11168	840
HPRD ID		04688	03457
Ensembl ID		ENSG00000164985	ENSG00000165806
Uniprot IDs		O75475	B4DWA2 P55210
PDB IDs		1Z9E 2B4J 2M16 3F9K 3HPG 3HPH 3U88 3ZEH 4FU6	1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2
Enriched GO Terms of Interacting Partners?		Oncogene-induced Cell Senescence Senescence-associated Heterochromatin Focus Assembly Positive Regulation Of Cellular Senescence Positive Regulation Of Cell Aging Positive Regulation Of Metabolic Process DNA Catabolic Process, Endonucleolytic Transcription, DNA-templated RNA Biosynthetic Process Heterochromatin Assembly Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Heterochromatin Organization DNA Catabolic Process Regulation Of Cellular Senescence Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Cellular Senescence Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Heterocycle Metabolic Process Interaction With Symbiont Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Base-excision Repair Regulation Of Viral Transcription Regulation Of Cell Cycle Cell Aging Execution Phase Of Apoptosis Positive Regulation Of Cellular Response To X-ray Sequestering Of Nodal From Receptor Via Nodal Binding Mesodermal-endodermal Cell Signaling Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Histone H2A-S139 Phosphorylation Chromosome Breakage Regulation Of Transcription, DNA-templated Regulation Of Endopeptidase Activity Regulation Of Nucleic Acid-templated Transcription	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Response To Stimulus Regulation Of Cellular Component Organization Cell Communication Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Signaling Myeloid Cell Differentiation System Development Regulation Of Metabolic Process Cellular Response To Organic Substance Viral Process Regulation Of Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Peptidase Activity Anatomical Structure Development Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Multicellular Organismal Development Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		aggressive arid1a arise carcinoids copy covalent drive exome far inactivation lung men1 modifiers mutated neuroendocrine observe perform progenitor pulmonary rare rb1 recurrently remodelling snf swi systematically tp53 transcriptome tumours	balb casp3 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tnfrsf1b tongue tradd trp53 wound wounds
Tagcloud (Difference) ?		aggressive arid1a arise carcinoids copy covalent drive exome far inactivation lung men1 modifiers mutated neuroendocrine observe perform progenitor pulmonary rare rb1 recurrently remodelling snf swi systematically tp53 transcriptome tumours	balb casp3 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tnfrsf1b tongue tradd trp53 wound wounds
Tagcloud (Intersection) ?