PRKCH and PARD6A

Number of citations of the paper that reports this interaction (PMID 17335965)
4

Data Source:
HPRD (in vivo)

		PRKCH	PARD6A
Gene Name		protein kinase C, eta	par-6 family cell polarity regulator alpha
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extracellular Vesicular Exosome	Ruffle Nucleus Cytosol Plasma Membrane Tight Junction Cell Cortex Protein Complex Apical Part Of Cell
	Molecular Function	Protein Kinase C Activity Calcium-independent Protein Kinase C Activity ATP Binding Ral GTPase Binding Enzyme Binding Metal Ion Binding	Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding GTP-dependent Protein Binding
	Biological Process	Protein Phosphorylation Signal Transduction Blood Coagulation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Platelet Activation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Protein Kinase C Signaling Regulation Of Tight Junction Assembly	Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell Junction Assembly Cell-cell Junction Organization Cell-cell Junction Maintenance Cell Division Tight Junction Assembly
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis	Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Obesity (early onset extreme) ( 23563609) Reading and spelling ( 23738518) Rheumatoid arthritis ( 22446963) Word reading ( 23738518)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: BANP CDK2 FYN GSK3A ITGB2 NFE2L2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SRC ZBTB8OS	24 interactors: CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ RAC1 RHOQ TCP10 TGFBR1 WDR83 YWHAH YWHAZ
Entrez ID		5583	50855
HPRD ID		05669	06316
Ensembl ID		ENSG00000027075	ENSG00000102981
Uniprot IDs		P24723	Q9NPB6
PDB IDs		2FK9 3TXO	1WMH
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Integrin-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Innate Immune Response Hemostasis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration Neurotrophin Signaling Pathway T Cell Costimulation Regulation Of Body Fluid Levels Chemotaxis Fc Receptor Signaling Pathway Wound Healing Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Response To Platelet-derived Growth Factor Negative Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Cellular Response To Peptide Cellular Response To Organic Substance Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Wounding Activated T Cell Proliferation Cell Proliferation Locomotion Immune Response Regulation Of Phosphorylation Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Axon Guidance Cell Migration Phosphatidylinositol-mediated Signaling Response To Oxidative Stress Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Movement Of Cell Or Subcellular Component Regulation Of Phosphorus Metabolic Process Cell Motility	Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Junction Organization Nervous System Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Tight Junction Assembly Signal Transduction Regulation Of Cell Death Regulation Of Cellular Component Organization System Development Positive Regulation Of Signal Transduction Apical Junction Assembly Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Transport Establishment Or Maintenance Of Cell Polarity Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cell Junction Assembly Multicellular Organismal Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Programmed Cell Death Response To Growth Factor Generation Of Neurons Wound Healing Anatomical Structure Development Cellular Response To Stimulus Positive Regulation Of Cell Death Cell-cell Junction Assembly Neurogenesis Regulation Of Establishment Of Protein Localization Regulation Of Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Protein Phosphorylation Developmental Process Regulation Of Protein Localization Regulation Of Kinase Activity Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation
Tagcloud ?		adjust adora2a avp cart cecal clp gng7 intramuscular ku myh7 oxt pde1b pdyn preconditioning prkcd puncture ratref reproduced rgs9 rxrg s100a8 sepsis six3 slc17a6 slco1a5 sostdc1 tac1 ttr ulinastatin
Tagcloud (Difference) ?		adjust adora2a avp cart cecal clp gng7 intramuscular ku myh7 oxt pde1b pdyn preconditioning prkcd puncture ratref reproduced rgs9 rxrg s100a8 sepsis six3 slc17a6 slco1a5 sostdc1 tac1 ttr ulinastatin
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