PRKCH and ZFP36L1

Data Source: HiPPIP (Novel)

		PRKCH	ZFP36L1
Name		protein kinase C eta	ZFP36 ring finger protein like 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extracellular Exosome	P-body Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Translation Regulator Activity Metal Ion Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding	DNA Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	Regulation Of Translation Protein Phosphorylation Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Translation In Response To Stress Cellular Response To Amino Acid Starvation Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Bicellular Tight Junction Assembly	MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Vasculogenesis Proepicardium Development MRNA Processing Regulation Of Translation Apoptotic Process Heart Development Cell Population Proliferation Response To Wounding Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Neural Tube Development Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of MRNA 3'-end Processing Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Multicellular Organism Growth P38MAPK Cascade Regulation Of MRNA Stability Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Monocyte Differentiation Regulation Of Myoblast Differentiation Mesendoderm Development Embryonic Organ Development MRNA Transport Chorio-allantoic Fusion 3'-UTR-mediated MRNA Destabilization ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Stem Cell Proliferation Cellular Response To Raffinose Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intracellular MRNA Localization
Pathways		Effects of PIP2 hydrolysis G alpha (z) signalling events	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
GWAS		Asthma ( 32296059 ) Height ( 28552196 ) Obesity (early onset extreme) ( 23563609 ) Reading and spelling ( 23738518 ) Rheumatoid arthritis ( 22446963 24390342 30423114 ) Word reading ( 23738518 ) Yeast infection ( 28928442 )	Apolipoprotein A1 levels ( 32203549 ) Arthritis (juvenile idiopathic) ( 33106285 ) Asthma ( 31959851 ) Blond vs. brown/black hair color ( 30531825 ) Celiac disease ( 22057235 20190752 25920553 ) Crohn's disease ( 21102463 ) Cutaneous malignant melanoma ( 32341527 ) Diastolic blood pressure ( 30224653 ) Fibrinogen levels ( 26561523 28107422 ) HDL cholesterol levels ( 32203549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Inflammatory bowel disease ( 23128233 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Microalbuminuria ( 31511532 ) Multiple sclerosis ( 24076602 21833088 ) Nonsyndromic cleft lip ( 31609978 ) Prostate cancer ( 23535732 ) Rheumatoid arthritis ( 32723749 ) Urinary albumin excretion ( 30220432 ) Urinary albumin-to-creatinine ratio ( 31630189 31511532 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		5 novel interactors: BMP4 C14orf39 SIX6 ZFP36L1 ZFYVE1	2 novel interactors: CSNK2B PRKCH
Interacting Genes		12 interacting genes: BANP CDK2 FYN GSK3A ITGB2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SRC ZBTB8OS	9 interacting genes: ACD AKT1 MAPK14 MAPKAPK2 PAFAH1B2 POT1 TERF1 TINF2 YWHAB
Entrez ID		5583	677
HPRD ID		05669	03041
Ensembl ID		ENSG00000027075	ENSG00000185650
Uniprot IDs		P24723	B3KNA8 Q07352
PDB IDs		2FK9 3TXO 8FP1 8FP3	1W0V 1W0W
GO Terms Enriched among Interactors		Regulation Of Cellular Localization Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Establishment Of Protein Localization Response To Growth Factor Forebrain Development Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization To Nucleus Integrin-mediated Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Response To Peptide Hormone Positive Regulation Of Establishment Of Protein Localization T Cell Costimulation Regulation Of Protein Localization To Nucleus Cellular Response To Hormone Stimulus Ephrin Receptor Signaling Pathway Negative Regulation Of Neutrophil Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Development Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Phospholipase Activator Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptide Hormone Receptor Binding Regulation Of Neutrophil Activation Positive Regulation Of Protein Localization BMP Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neutrophil Activation Involved In Immune Response Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Adhesion Regulation Of Striated Muscle Cell Differentiation Protein Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Intracellular Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Chemical Stress Negative Regulation Of Cell Cycle Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Differentiation Regulation Of Developmental Process Leukocyte Activation Tau-protein Kinase Activity Stimulatory C-type Lectin Receptor Signaling Pathway	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomerase Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Metabolic Process RNA-templated DNA Biosynthetic Process Regulation Of Telomere Maintenance Cellular Response To Vascular Endothelial Growth Factor Stimulus Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Protein Serine/threonine Kinase Activity Chromosome, Telomeric Region Regulation Of Establishment Of Protein Localization To Telomere Regulation Of DNA Metabolic Process Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Metabolic Process Regulation Of Chromosome Organization Telomeric D-loop Disassembly RNA Stabilization G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region DNA Biosynthetic Process Negative Regulation Of RNA Catabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process