PRKCH and NUMB

Number of citations of the paper that reports this interaction (PMID 17203073)
60

Data Source:
HPRD (in vitro)

		PRKCH	NUMB
Gene Name		protein kinase C, eta	numb homolog (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extracellular Vesicular Exosome	Nucleus Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell
	Molecular Function	Protein Kinase C Activity Calcium-independent Protein Kinase C Activity ATP Binding Ral GTPase Binding Enzyme Binding Metal Ion Binding	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Protein Phosphorylation Signal Transduction Blood Coagulation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Platelet Activation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Protein Kinase C Signaling Regulation Of Tight Junction Assembly	Notch Signaling Pathway Axon Guidance Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Positive Regulation Of Polarized Epithelial Cell Differentiation Adherens Junction Organization Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Neurogenesis Lung Epithelial Cell Differentiation Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis	Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH L1CAM interactions Recycling pathway of L1 Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Degradation of GLI1 by the proteasome Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Obesity (early onset extreme) ( 23563609) Reading and spelling ( 23738518) Rheumatoid arthritis ( 22446963) Word reading ( 23738518)	Bipolar disorder (mood-incongruent) ( 23092984) Coronary artery calcification ( 17903303)
Protein-Protein Interactions		13 interactors: BANP CDK2 FYN GSK3A ITGB2 NFE2L2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SRC ZBTB8OS	24 interactors: AP2A1 AP2A2 APP DPYSL2 EGFR EPS15 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MDM2 NOTCH1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ RPL3 SIAH1
Entrez ID		5583	8650
HPRD ID		05669	04767
Ensembl ID		ENSG00000027075	ENSG00000133961
Uniprot IDs		P24723	P49757
PDB IDs		2FK9 3TXO
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Integrin-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Innate Immune Response Hemostasis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration Neurotrophin Signaling Pathway T Cell Costimulation Regulation Of Body Fluid Levels Chemotaxis Fc Receptor Signaling Pathway Wound Healing Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Response To Platelet-derived Growth Factor Negative Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Cellular Response To Peptide Cellular Response To Organic Substance Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Wounding Activated T Cell Proliferation Cell Proliferation Locomotion Immune Response Regulation Of Phosphorylation Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Axon Guidance Cell Migration Phosphatidylinositol-mediated Signaling Response To Oxidative Stress Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Movement Of Cell Or Subcellular Component Regulation Of Phosphorus Metabolic Process Cell Motility	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Blood Coagulation Hemostasis Response To Growth Factor Wound Healing Platelet Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Activation Response To Wounding Regulation Of Immune System Process Regulation Of Body Fluid Levels Immune System Process Cell Surface Receptor Signaling Pathway Response To External Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Signaling Regulation Of Phospholipase Activity Chemotaxis Positive Regulation Of Lipase Activity Neuron Projection Morphogenesis Signal Transduction Cellular Response To Organic Substance Signaling Response To Organic Substance Axonogenesis Defense Response Activation Of Phospholipase C Activity Cell Communication Cellular Response To Stimulus Axon Development Neuron Projection Development Innate Immune Response Negative Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Phospholipase C Activity Regulation Of Cellular Amino Acid Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Part Morphogenesis Negative Regulation Of Signaling Response To Stimulus
Tagcloud ?		adjust adora2a avp cart cecal clp gng7 intramuscular ku myh7 oxt pde1b pdyn preconditioning prkcd puncture ratref reproduced rgs9 rxrg s100a8 sepsis six3 slc17a6 slco1a5 sostdc1 tac1 ttr ulinastatin	adapter affinities arise asymmetric bind bond contain diverse division domain gp gppy helical hydrogen ldnpay library lnx modes motif nak nmr npxy peptide phosphotyrosine ptb reveals sheet turn y
Tagcloud (Difference) ?		adjust adora2a avp cart cecal clp gng7 intramuscular ku myh7 oxt pde1b pdyn preconditioning prkcd puncture ratref reproduced rgs9 rxrg s100a8 sepsis six3 slc17a6 slco1a5 sostdc1 tac1 ttr ulinastatin	adapter affinities arise asymmetric bind bond contain diverse division domain gp gppy helical hydrogen ldnpay library lnx modes motif nak nmr npxy peptide phosphotyrosine ptb reveals sheet turn y
Tagcloud (Intersection) ?