PRKCH and SIX6

		PRKCH	SIX6
Description		protein kinase C eta	SIX homeobox 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extracellular Exosome	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Translation Regulator Activity Metal Ion Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Translation Protein Phosphorylation Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Translation In Response To Stress Cellular Response To Amino Acid Starvation Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Bicellular Tight Junction Assembly	Eye Development Regulation Of Transcription By RNA Polymerase II Visual Perception Animal Organ Morphogenesis
Pathways		Effects of PIP2 hydrolysis G alpha (z) signalling events
Drugs
Diseases			Anophthalmia and microphthalmia (A/M)
GWAS		Asthma ( 32296059) Height ( 28552196) Obesity (early onset extreme) ( 23563609) Reading and spelling ( 23738518) Rheumatoid arthritis ( 22446963 24390342 30423114) Word reading ( 23738518) Yeast infection ( 28928442)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 22419738 33627673 29891935 29452408 22570617 25173105) Gut microbiota (bacterial taxa) ( 27723756) Height ( 20881960 25429064) Medication use (antiglaucoma preparations and miotics) ( 31015401) Menarche (age at onset) ( 25231870) Optic cup area ( 28073927 25631615 31798171) Optic disc area ( 25631615 28073927 31798171) Refractive error ( 23396134 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio ( 28073927 31798171 25241763)
Interacting Genes		12 interacting genes: BANP CDK2 FYN GSK3A ITGB2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SRC ZBTB8OS	3 interacting genes: GTF2A1L TLE1 TLE5
Entrez ID		5583	4990
HPRD ID		05669	07557
Ensembl ID		ENSG00000027075	ENSG00000184302
Uniprot IDs		P24723	O95475 Q6P051
PDB IDs		2FK9 3TXO 8FP1 8FP3
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Localization Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Establishment Of Protein Localization Response To Growth Factor Forebrain Development Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization To Nucleus Integrin-mediated Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Response To Peptide Hormone Positive Regulation Of Establishment Of Protein Localization T Cell Costimulation Regulation Of Protein Localization To Nucleus Cellular Response To Hormone Stimulus Ephrin Receptor Signaling Pathway Negative Regulation Of Neutrophil Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Development Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Phospholipase Activator Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptide Hormone Receptor Binding Regulation Of Neutrophil Activation Positive Regulation Of Protein Localization BMP Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neutrophil Activation Involved In Immune Response Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Adhesion Regulation Of Striated Muscle Cell Differentiation Protein Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Intracellular Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Chemical Stress Negative Regulation Of Cell Cycle Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Differentiation Regulation Of Developmental Process Leukocyte Activation Tau-protein Kinase Activity Stimulatory C-type Lectin Receptor Signaling Pathway	Regulation Of Anoikis Transcription Corepressor Activity Positive Regulation Of Anoikis Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of B Cell Receptor Signaling Pathway Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Translation In Response To Stress Transcription Factor TFIIA Complex Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Glial Cell Proliferation Regulation Of B Cell Receptor Signaling Pathway Translation Regulator Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Keratinocyte Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine Kinase Binding Beta-catenin-TCF Complex Negative Regulation Of Anoikis Regulation Of PERK-mediated Unfolded Protein Response Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Epidermal Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?