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GALT and NQO1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
GALT
NQO1
Description
galactose-1-phosphate uridylyltransferase
NAD(P)H quinone dehydrogenase 1
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Cytosol
Nucleus
Cytoplasm
Cytosol
Synapse
Molecular Function
Protein Binding
UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity
Zinc Ion Binding
Transferase Activity
Nucleotidyltransferase Activity
Metal Ion Binding
RNA Binding
NAD(P)H Dehydrogenase (quinone) Activity
Cytochrome-b5 Reductase Activity, Acting On NAD(P)H
Protein Binding
NADPH Dehydrogenase (quinone) Activity
Oxidoreductase Activity
Identical Protein Binding
NADH Dehydrogenase (quinone) (non-electrogenic) Activity
Biological Process
UDP-alpha-D-glucose Metabolic Process
Galactose Metabolic Process
Phosphate-containing Compound Metabolic Process
Organophosphate Metabolic Process
Galactose Catabolic Process Via UDP-galactose, Leloir Pathway
Carbohydrate Derivative Metabolic Process
Protein Polyubiquitination
Ubiquinone Metabolic Process
Xenobiotic Metabolic Process
Nitric Oxide Biosynthetic Process
Response To Oxidative Stress
Synaptic Transmission, Cholinergic
Response To Toxic Substance
Removal Of Superoxide Radicals
Protein Catabolic Process
Response To Lipopolysaccharide
Cellular Response To Oxidative Stress
Negative Regulation Of Protein Catabolic Process
Vitamin E Metabolic Process
Vitamin K Metabolic Process
Innate Immune Response
Cell Redox Homeostasis
Response To Caloric Restriction
Negative Regulation Of Ferroptosis
Pathways
Defective GALT can cause GALCT
Galactose catabolism
Regulation of ornithine decarboxylase (ODC)
NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs
Menadione
Dicoumarol
Duroquinone
3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol
ES-936
Cibacron Blue
Flavin adenine dinucleotide
5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione
RH-1
Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone]
3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE
Cannabidiol
Diseases
Galactosemia
GWAS
Alcohol consumption (drinks per week) (
30679032
)
Blood osmolality (transformed sodium) (
28360221
)
Blood protein levels (
30072576
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body mass index (
26426971
)
Estimated glomerular filtration rate (
31015462
)
Mean platelet volume (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Triglyceride levels (
32203549
)
Interacting Genes
6 interacting genes:
GRPEL1
KRTAP6-2
NQO1
TNK2
TRIP13
VAC14
10 interacting genes:
CDC42
DNAJB1
GALT
HIF1A
HSPA1A
ING1
PRKN
STUB1
TP53
UBE2D1
Entrez ID
2592
1728
HPRD ID
06106
00518
Ensembl ID
ENSG00000213930
ENSG00000181019
Uniprot IDs
A0A0S2Z3Y7
B2RAT6
P07902
B4DLR8
P15559
PDB IDs
5IN3
6GQD
1D4A
1DXO
1GG5
1H66
1H69
1KBO
1KBQ
1QBG
2F1O
3JSX
4CET
4CF6
5A4K
5EA2
5EAI
5FUQ
6FY4
6LLC
8C9J
8OK0
8PQN
8RFM
8RFN
Enriched GO Terms of Interacting Partners
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Regulation Of Receptor-mediated Endocytosis
CCR7 Chemokine Receptor Binding
Regulation Of Dendritic Cell Dendrite Assembly
Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Establishment Of T Cell Polarity
Negative Regulation Of Dendritic Cell Apoptotic Process
Regulation Of Endocytosis
Chemokine Receptor Binding
Immunological Synapse Formation
Identical Protein Binding
Dendritic Cell Chemotaxis
Positive Regulation Of Glycoprotein Biosynthetic Process
Cellular Response To Prostaglandin E Stimulus
Eosinophil Chemotaxis
Positive Regulation Of Glycoprotein Metabolic Process
Cell Maturation
Eosinophil Migration
Regulation Of Antigen Processing And Presentation
Dendritic Cell Migration
Positive Regulation Of Neutrophil Chemotaxis
Response To Prostaglandin E
Positive Regulation Of Granulocyte Chemotaxis
Cellular Response To Prostaglandin Stimulus
CCR Chemokine Receptor Binding
Regulation Of Vesicle-mediated Transport
Positive Regulation Of Neutrophil Migration
Developmental Maturation
Regulation Of Neutrophil Chemotaxis
Regulation Of Glycoprotein Biosynthetic Process
Regulation Of Neutrophil Migration
T Cell Costimulation
Chemokine Activity
Regulation Of Granulocyte Chemotaxis
Positive Regulation Of Receptor-mediated Endocytosis
Release Of Sequestered Calcium Ion Into Cytosol
Negative Regulation Of Leukocyte Apoptotic Process
Cell-cell Recognition
Negative Regulation Of Sequestering Of Calcium Ion
NADH Dehydrogenase (quinone) (non-electrogenic) Activity
Positive Regulation Of Dendritic Cell Dendrite Assembly
Dendritic Cell Dendrite Assembly
Negative Regulation Of Dendritic Cell Dendrite Assembly
PAS Complex
Granulocyte Chemotaxis
Chemokine-mediated Signaling Pathway
Calcium Ion Transmembrane Import Into Cytosol
Granulocyte Migration
Establishment Of Cell Polarity
Positive Regulation Of Leukocyte Chemotaxis
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Post-translational Protein Modification
Protein-folding Chaperone Binding
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Topologically Incorrect Protein
Ubiquitin Protein Ligase Binding
Regulation Of Growth
Histone Deacetylase Binding
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cellular Component Organization
Regulation Of Cell Growth
Enzyme Binding
Hsp70 Protein Binding
Regulation Of Mitophagy
Protein-containing Complex
Cellular Response To Heat
Regulation Of Autophagy Of Mitochondrion
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Regulation Of Macroautophagy
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cytokine-mediated Signaling Pathway
Heat Shock Protein Binding
Negative Regulation Of Apoptotic Process
Negative Regulation Of Growth
Negative Regulation Of Signal Transduction
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Response To Cytokine Stimulus
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Component Biogenesis
Response To Endoplasmic Reticulum Stress
G Protein-coupled Receptor Binding
Protein Stabilization
Regulation Of Programmed Cell Death
Regulation Of Cellular Response To Stress
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Purine Nucleotide Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Unfolded Protein
Response To Heat
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