GALT and GRPEL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GALT	GRPEL1
Description		galactose-1-phosphate uridylyltransferase	GrpE like 1, mitochondrial
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol	PAM Complex, Tim23 Associated Import Motor Nucleoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix
	Molecular Function	Protein Binding UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	UDP-alpha-D-glucose Metabolic Process Galactose Metabolic Process Phosphate-containing Compound Metabolic Process Organophosphate Metabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway Carbohydrate Derivative Metabolic Process	Protein Folding Intracellular Protein Transport Protein Import Into Mitochondrial Matrix
Pathways		Defective GALT can cause GALCT Galactose catabolism	Mitochondrial protein import
Drugs
Diseases		Galactosemia
GWAS			Eosinophil percentage of white cells ( 32888494)
Interacting Genes		6 interacting genes: GRPEL1 KRTAP6-2 NQO1 TNK2 TRIP13 VAC14	7 interacting genes: CCDC57 ERCC6 GALT ISG15 POLR1C SPG21 WBP2
Entrez ID		2592	80273
HPRD ID		06106	07550
Ensembl ID		ENSG00000213930	ENSG00000109519
Uniprot IDs		A0A0S2Z3Y7 B2RAT6 P07902	Q9HAV7
PDB IDs		5IN3 6GQD	9BLS 9BLT 9BLU
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor-mediated Endocytosis CCR7 Chemokine Receptor Binding Regulation Of Dendritic Cell Dendrite Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Establishment Of T Cell Polarity Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Endocytosis Chemokine Receptor Binding Immunological Synapse Formation Identical Protein Binding Dendritic Cell Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Eosinophil Chemotaxis Positive Regulation Of Glycoprotein Metabolic Process Cell Maturation Eosinophil Migration Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Response To Prostaglandin E Positive Regulation Of Granulocyte Chemotaxis Cellular Response To Prostaglandin Stimulus CCR Chemokine Receptor Binding Regulation Of Vesicle-mediated Transport Positive Regulation Of Neutrophil Migration Developmental Maturation Regulation Of Neutrophil Chemotaxis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Neutrophil Migration T Cell Costimulation Chemokine Activity Regulation Of Granulocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Leukocyte Apoptotic Process Cell-cell Recognition Negative Regulation Of Sequestering Of Calcium Ion NADH Dehydrogenase (quinone) (non-electrogenic) Activity Positive Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly PAS Complex Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Granulocyte Migration Establishment Of Cell Polarity Positive Regulation Of Leukocyte Chemotaxis
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