PIKFYVE and RABEPK

Number of citations of the paper that reports this interaction (PMID 14530284)
20

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PIKFYVE	RABEPK
Gene Name		phosphoinositide kinase, FYVE finger containing	Rab9 effector protein with kelch motifs
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Cell-cell Junction Endosome Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Membrane Raft Perinuclear Region Of Cytoplasm	Endosome Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Metal Ion Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Myelin Assembly Protein Localization To Nucleus Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Retrograde Transport, Endosome To Golgi Cellular Protein Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation	Receptor-mediated Endocytosis Vesicle Docking Involved In Exocytosis
Pathways		Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Phospholipid metabolism Synthesis of PIPs at the late endosome membrane PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APP RABEPK VAC14	7 interactors: GLUL PIKFYVE POR PRKRA RAB9A TMEM98 ZYX
Entrez ID		200576	10244
HPRD ID		17852	09337
Ensembl ID		ENSG00000115020	ENSG00000136933
Uniprot IDs		Q9Y2I7	Q7Z6M1
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Secretion By Cell	Retrograde Transport, Endosome To Golgi Cellular Organofluorine Metabolic Process Nitrate Catabolic Process Nitric Oxide Catabolic Process Cellular Response To Stimulus Glutamine Biosynthetic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitrate Metabolic Process Lipid Modification Endosomal Transport Response To Organic Substance Glutamate Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Response To Stimulus Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Outer Ear Morphogenesis Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Secretion Production Of SiRNA Involved In RNA Interference Neurotransmitter Uptake Dicarboxylic Acid Catabolic Process Carnitine Metabolic Process Stress Fiber Assembly RNA Interference Cellular Response To Follicle-stimulating Hormone Stimulus Regulation Of Cell Proliferation Amino-acid Betaine Metabolic Process Response To Nutrient Levels Negative Regulation Of Lipase Activity Regulation Of Cholesterol Biosynthetic Process Response To Extracellular Stimulus Response To Follicle-stimulating Hormone Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Gonadotropin Stimulus Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamate Metabolic Process Flavonoid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Middle Ear Morphogenesis Nitric Oxide Metabolic Process Regulation Of Cholesterol Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Chondrocyte Differentiation Response To External Stimulus Cellular Response To Organic Substance Myelin Assembly Regulation Of Hormone Metabolic Process
Tagcloud ?		accordingly amp ampk atpase carriers channels creatine depleted downregulates ensures exchanger gap glycogen gsk3beta gtpase junctional labels membane monocarboxylate na osmolyte profoundly pumps rab sensing stabilizes tbc1d1 tensin transporters
Tagcloud (Difference) ?		accordingly amp ampk atpase carriers channels creatine depleted downregulates ensures exchanger gap glycogen gsk3beta gtpase junctional labels membane monocarboxylate na osmolyte profoundly pumps rab sensing stabilizes tbc1d1 tensin transporters
Tagcloud (Intersection) ?