PIKFYVE and MIR140

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		PIKFYVE	MIR140
Description		phosphoinositide kinase, FYVE-type zinc finger containing	microRNA 140
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Cytosol Endosome Membrane Vesicle Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Membrane Raft	Extracellular Space RISC Complex
	Molecular Function	Nucleotide Binding 1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Metal Ion Binding Phosphatidylinositol Kinase Activity 1-phosphatidylinositol-5-kinase Activity Protein Serine Kinase Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Protein Targeting To Membrane Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Intracellular Protein Localization Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neutrophil Chemotaxis Melanosome Organization Protein Localization To Nucleus Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Retrograde Transport, Endosome To Golgi Phosphatidylinositol Metabolic Process Phagosome Maturation Phagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly	Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Defense Response To Bacterium Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Osteoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Vascular Endothelial Growth Factor Production Cellular Response To Amyloid-beta Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases		Fleck corneal dystrophy (FCD); Francois-Neetens speckled corneal dystrophy
GWAS		Adult asthma ( 27611488) Post bronchodilator FEV1 ( 26634245)	Body mass index ( 26426971)
Interacting Genes		6 interacting genes: APP CDK5 H3C1 MIR140 RABEPK VAC14	68 interacting genes: ADARB1 AIMP1 APOBEC3B C1QBP CELF1 CELF2 CRTAP CSTF1 DARS1 DDX1 DDX21 DDX3X DDX49 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 PDCD11 PIKFYVE PIP5K1A PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RTCB SF3B1 SF3B3 SFPQ SYNCRIP TAF15 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3
Entrez ID		200576	406932
HPRD ID		17852
Ensembl ID		ENSG00000115020	ENSG00000208017
Uniprot IDs		Q9Y2I7
PDB IDs		7K2V
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Cellular Response To Amyloid-beta Response To Amyloid-beta Amyloid-beta Complex Growth Cone Lamellipodium Visual Behavior Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Endocytosis Regulation Of Receptor Internalization Glial Cell Development Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration PAS Complex PTB Domain Binding Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Positive Regulation Of Programmed Cell Death Regulation Of Chemokine Production Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Growth Cone Regulation Of Receptor-mediated Endocytosis Regulation Of Postsynapse Organization Lipoprotein Particle Regulation Of Vesicle-mediated Transport Perikaryon Import Into Cell Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Developmental Cell Growth Microglia Development Developmental Growth Involved In Morphogenesis Positive Regulation Of G Protein-coupled Receptor Internalization ErbB-2 Class Receptor Binding Protein Kinase 5 Complex Negative Regulation Of Synaptic Plasticity Cerebellar Cortex Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Adult Behavior Regulation Of Interleukin-6 Production Axonogenesis Learning	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing MRNA Binding Macromolecule Metabolic Process Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome Nucleus RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleoplasm Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Spliceosomal Complex Regulation Of Gene Expression Catalytic Step 2 Spliceosome Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Regulation Of Translation Regulation Of Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of RNA Catabolic Process MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability RNA Stabilization Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process MiRNA Binding TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Translation Regulation Of Nucleobase-containing Compound Metabolic Process TRNA Aminoacylation Nucleolus
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