EIF2S1 and PPP1R15A

Number of citations of the paper that reports this interaction (PMID 12556489)
72

Data Source:
HPRD (in vivo, in vitro)

		EIF2S1	PPP1R15A
Gene Name		eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	protein phosphatase 1, regulatory subunit 15A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Extracellular Vesicular Exosome	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Poly(A) RNA Binding	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Regulator Activity Protein Kinase Binding Protein Phosphatase Type 1 Activator Activity
	Biological Process	Translation Translational Initiation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gene Expression Endoplasmic Reticulum Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Cellular Protein Metabolic Process Protein Autophosphorylation	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Transcription From RNA Polymerase I Promoter Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation
Pathways		Translation initiation complex formation Recycling of eIF2:GDP Translation L13a-mediated translational silencing of Ceruloplasmin expression Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation PERK regulates gene expression Unfolded Protein Response (UPR)	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: CASP3 CASP6 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 MELK P4HB PPP1R15A PRKCD PRKRIR SFN TERT	16 interactors: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B
Entrez ID		1965	23645
HPRD ID		04881	06572
Ensembl ID		ENSG00000134001	ENSG00000087074
Uniprot IDs		P05198 Q53XC0	O75807
PDB IDs		1KL9 1Q8K
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Regulation Of Translation Negative Regulation Of Translation Cellular Response To Stress Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To Stress Translation Translational Initiation Oligodendrocyte Development Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Apoptotic Process Oligodendrocyte Differentiation Protein Metabolic Process Programmed Cell Death Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Regulation Of Apoptotic Process Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Glial Cell Development Response To Heat Cellular Protein Metabolic Process Response To Glucose Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Cell Death Response To Organic Substance Response To Endoplasmic Reticulum Stress Regulation Of Protein Phosphorylation Response To Stimulus Glial Cell Differentiation Positive Regulation Of Metabolic Process Response To Carbohydrate Gene Expression	Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Protein Refolding Gene Expression Viral Genome Replication Blood Coagulation Cell Division Hemostasis Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Viral Life Cycle Regulation Of Cellular Process Platelet Activation Cellular Metabolic Process B Cell Receptor Signaling Pathway Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Body Fluid Levels Wound Healing Cellular Response To Stimulus Positive Regulation Of Oligodendrocyte Progenitor Proliferation Metanephric Macula Densa Development Metanephric DCT Cell Differentiation Positive Regulation Of Cellular Response To Drug Negative Regulation Of Mast Cell Proliferation Glycogen Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Heat Response To Wounding Platelet Degranulation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Heat Acclimation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Polysaccharide Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic
Tagcloud (Difference) ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba releasing rep reperfusion sensor tg thapsigargin tm tmcao transient tunicamycin	ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected restoration sci traumatic
Tagcloud (Intersection) ?		protects rescue