EIF2S1 and EIF2B1

Number of citations of the paper that reports this interaction (PubMedID 8887689)
29

Data Source:
HPRD (in vivo)

		EIF2S1	EIF2B1
Description		eukaryotic translation initiation factor 2 subunit alpha	eukaryotic translation initiation factor 2B subunit alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Eukaryotic Translation Initiation Factor 2 Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Mitophagy Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Mitochondrial Respirasome Assembly HRI-mediated Signaling Response To Kainic Acid Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Cytoplasmic Translational Initiation Translation Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress	Recycling of eIF2:GDP
Drugs
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS			Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		28 interacting genes: ACTN1 ANXA1 CASP3 CASP6 CDC37 CEBPA CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12 VAC14	21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I
Entrez ID		1965	1967
HPRD ID		04881	09458
Ensembl ID		ENSG00000134001	ENSG00000111361
Uniprot IDs		P05198 Q53XC0	Q14232
PDB IDs		1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z 6YBV 6ZMW 6ZP4 7A09 7D43 7D44 7D45 7F66 7F67 7NZM 7QP6 7QP7 7SYR 7SYS 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PPL 8QZZ	3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMA 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQZ
Enriched GO Terms of Interacting Partners?		Translational Initiation Eukaryotic Translation Initiation Factor 2B Complex Translation Initiation Factor Activity Cytosol Regulation Of Translational Initiation Response To Stress Post-transcriptional Regulation Of Gene Expression Cytoplasmic Translational Initiation Protein Metabolic Process Response To Temperature Stimulus Response To Heat Regulation Of Apoptotic Process Regulation Of Translation Regulation Of Programmed Cell Death Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Regulation Of Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Signal Transduction Oligodendrocyte Development Positive Regulation Of Immune System Process Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Apoptotic Signaling Pathway Translation Protein Serine Kinase Activity Regulation Of Immune Response Intracellular Signal Transduction Response To Glucose Cellular Response To Stress Response To Monosaccharide Protein Serine/threonine Kinase Activity Glial Cell Development Activation Of Immune Response Translation Factor Activity, RNA Binding Response To Carbohydrate Cell Development Protein Kinase C Inhibitor Activity Positive Regulation Of Immune Response Identical Protein Binding Response To Peptide Hormone Cytoplasm Regulation Of Gene Expression Regulation Of Stem Cell Proliferation Negative Regulation Of Translation Protein Kinase Activity Regulation Of Macromolecule Biosynthetic Process Cellular Response To Staurosporine Protein Kinase C Signaling Protein Folding	Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Regulation Of Smooth Muscle Contraction Norepinephrine Binding Eukaryotic Translation Initiation Factor 2 Complex Regulation Of Catecholamine Secretion Translation Initiation Factor Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Uterine Smooth Muscle Contraction Regulation Of Muscle Contraction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Smooth Muscle Contraction ERBB Signaling Pathway Regulation Of Amine Transport Translational Initiation Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of Muscle Contraction Vascular Process In Circulatory System Regulation Of Translational Initiation Circulatory System Process Cytoplasmic Translational Initiation Negative Regulation Of Insulin Secretion Negative Regulation Of Secretion By Cell G Protein-coupled Receptor Activity Negative Regulation Of Uterine Smooth Muscle Contraction Alpha-1B Adrenergic Receptor Binding Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Temperature Stimulus Translation Initiation Ternary Complex Translation SUMO Conjugating Enzyme Activity Carbohydrate Phosphatase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of Secretion Negative Regulation Of Peptide Secretion Macromolecule Biosynthetic Process Protein Metabolic Process
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