EIF2S1 and EIF2AK1

Number of citations of the paper that reports this interaction (PMID 9819435)
156

Data Source:
HPRD (in vivo)

		EIF2S1	EIF2AK1
Gene Name		eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	eukaryotic translation initiation factor 2-alpha kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Poly(A) RNA Binding	Eukaryotic Translation Initiation Factor 2alpha Kinase Activity ATP Binding Heme Binding Protein Homodimerization Activity
	Biological Process	Translation Translational Initiation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gene Expression Endoplasmic Reticulum Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Cellular Protein Metabolic Process Protein Autophosphorylation	Response To Stress Negative Regulation Of Cell Proliferation Response To External Stimulus Regulation Of EIF2 Alpha Phosphorylation By Heme Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Negative Regulation Of Hemoglobin Biosynthetic Process
Pathways		Translation initiation complex formation Recycling of eIF2:GDP Translation L13a-mediated translational silencing of Ceruloplasmin expression Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: CASP3 CASP6 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 MELK P4HB PPP1R15A PRKCD PRKRIR SFN TERT	4 interactors: CDC37 EIF2S1 HSP90AA1 LIG4
Entrez ID		1965	27102
HPRD ID		04881	10684
Ensembl ID		ENSG00000134001	ENSG00000086232
Uniprot IDs		P05198 Q53XC0	B4DIP4 Q9BQI3
PDB IDs		1KL9 1Q8K
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Regulation Of Translation Negative Regulation Of Translation Cellular Response To Stress Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To Stress Translation Translational Initiation Oligodendrocyte Development Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Apoptotic Process Oligodendrocyte Differentiation Protein Metabolic Process Programmed Cell Death Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Regulation Of Apoptotic Process Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Glial Cell Development Response To Heat Cellular Protein Metabolic Process Response To Glucose Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Cell Death Response To Organic Substance Response To Endoplasmic Reticulum Stress Regulation Of Protein Phosphorylation Response To Stimulus Glial Cell Differentiation Positive Regulation Of Metabolic Process Response To Carbohydrate Gene Expression	DNA Ligation Involved In DNA Recombination Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Protein Folding Lagging Strand Elongation Pro-B Cell Differentiation Cellular Response To Stress Establishment Of Integrated Proviral Latency Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Regulation Of Translational Initiation In Response To Stress DNA Ligation Involved In DNA Repair Protein Targeting Lymphoid Progenitor Cell Differentiation Posttranscriptional Regulation Of Gene Expression Chaperone-mediated Protein Complex Assembly DNA Ligation Regulation Of Translation In Response To Stress Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Protein Refolding Regulation Of Interferon-gamma-mediated Signaling Pathway Single Strand Break Repair Regulation Of Response To Interferon-gamma Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Catalytic Activity Isotype Switching Nitric Oxide Metabolic Process V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Response To Lithium Ion Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process DNA Strand Elongation Response To X-ray Regulation Of Protein Kinase Activity Somatic Recombination Of Immunoglobulin Gene Segments Regulation Of Kinase Activity Somatic Diversification Of Immunoglobulins Regulation Of Nitric-oxide Synthase Activity Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Regulation Of Immune Response B Cell Activation Involved In Immune Response Intracellular Protein Transport Intracellular Protein Transmembrane Transport Response To Gamma Radiation
Tagcloud ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	activates affects arginine coordinately depletion eukaryotic gcn2 hri indirectly inducible innate kinases mediate nitric nos oxide pathological perk phosphorylate physiological pkr synthase uniquely upstream
Tagcloud (Difference) ?		atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin	activates affects arginine coordinately depletion eukaryotic gcn2 hri indirectly inducible innate kinases mediate nitric nos oxide pathological perk phosphorylate physiological pkr synthase uniquely upstream
Tagcloud (Intersection) ?