SRGN and CEP70

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SRGN	CEP70
Gene Name		serglycin	centrosomal protein 70kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Platelet Alpha Granule Lumen Zymogen Granule Mast Cell Granule	Nucleoplasm Cytoplasm Centrosome Cytosol Nuclear Membrane
	Molecular Function	Protein Binding Collagen Binding	Protein Binding
	Biological Process	Platelet Degranulation Blood Coagulation Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Platelet Activation Negative Regulation Of Bone Mineralization Biomineral Tissue Development Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Negative Regulation Of Cytokine Secretion	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ALB BAG6 CCL3 CD44 CEP70 GZMB PF4 PSRC1 SGTA UBQLN1 UBQLN4 UBR4	134 interactors: ABT1 AKAP17A ARHGEF3 ATP5O ATXN7 BARD1 BEX2 BRMS1 BYSL C11orf57 C1orf35 C7orf25 C8orf33 CARD9 CCDC85B CCDC94 CDC73 CDCA7L CEP57L1 CFAP53 CLPB COIL DAZAP2 DDX41 DDX6 DIEXF DNAJB11 EMD EMP1 ENKD1 ERCC3 FAM118B FAM124A FAM133A FAM13C FAM161A FAM214B FAM64A GATAD2B GCC1 GPATCH2L GPATCH4 GPX7 HAUS1 HMGB4 HSPD1 IK IQCE KANK2 KANSL1 KAT7 KDM1A KRT31 LAMTOR5 LENG1 LENG8 LIN37 MCM10 MEST METTL17 MFAP1 MRPL44 NIPSNAP3A NKAP NOL12 NOP2 NRIP1 NUSAP1 PAM16 PLA2G2A PPFIA1 PPIG PPP1R16B PRKRIP1 PRPF31 PSMA1 RCOR3 RPL13 SERPINH1 SETD5 SFR1 SH2D4A SLU7 SMARCE1 SNRPD2 SRGN SSX3 STK25 STMN2 SUV39H1 SUV39H2 SYT17 SYTL4 SYTL5 TAF1D TCEB3 TCEB3B TEAD4 TRIM29 TRIM42 TSGA10IP TSHZ3 TTC25 TTLL10 TXLNB UTP11L UTP14A ZBTB16 ZBTB24 ZBTB49 ZBTB8A ZCCHC10 ZFC3H1 ZGPAT ZNF136 ZNF148 ZNF169 ZNF227 ZNF239 ZNF266 ZNF302 ZNF329 ZNF366 ZNF408 ZNF410 ZNF417 ZNF426 ZNF439 ZNF490 ZNF555 ZNF572 ZNF578 ZNF587 ZSCAN12
Entrez ID		5552	80321
HPRD ID		01513	16779
Ensembl ID		ENSG00000122862	ENSG00000114107
Uniprot IDs		P10124	B7Z2D2 Q8NHQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Behavior Cytolysis Regulation Of Behavior Leukocyte Migration Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Leukocyte Chemotaxis Exocytosis Platelet Degranulation Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Leukocyte Migration Positive Regulation Of Monocyte Aggregation Maintenance Of Mitochondrion Location Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Cell Death Blood Coagulation Inflammatory Response Hemostasis Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Myeloid Leukocyte Differentiation Regulation Of Leukocyte Migration Monocyte Aggregation Response To Platinum Ion Negative Regulation Of Cytolysis Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Eosinophil Degranulation Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chemotaxis Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Natural Killer Cell Chemotaxis Granzyme-mediated Apoptotic Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Immune System Process Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Negative Regulation Of MHC Class II Biosynthetic Process Wound Healing Immune Response	RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process RNA Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Cellular Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Ribonucleoprotein Complex Biogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process RRNA Processing Regulation Of Cellular Process RRNA Metabolic Process Ribosomal Small Subunit Biogenesis Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification MRNA Metabolic Process Metabolic Process Ribosome Biogenesis Histone H3-K9 Dimethylation RNA Processing Chromatin Organization Histone Modification Maturation Of SSU-rRNA Chromosome Organization Cell Death Death Histone H3-K9 Trimethylation Peptidyl-lysine Dimethylation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Apoptotic Process
Tagcloud ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a trem2 tubal3 txnrd1
Tagcloud (Difference) ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a trem2 tubal3 txnrd1
Tagcloud (Intersection) ?