SRGN and PEX12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SRGN	PEX12
Description		serglycin	peroxisomal biogenesis factor 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Golgi Apparatus Secretory Granule Extracellular Matrix Platelet Alpha Granule Lumen Mast Cell Granule Cytolytic Granule	Peroxisome Peroxisomal Membrane Cytosol Membrane Peroxisomal Importomer Complex
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Transmembrane Transporter Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Activator Activity
	Biological Process	Negative Regulation Of Cytokine Production Apoptotic Process Protein Processing Negative Regulation Of Bone Mineralization Biomineral Tissue Development Secretory Granule Organization Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Granzyme-mediated Programmed Cell Death Signaling Pathway	Protein Polyubiquitination Pexophagy Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Targeting To Peroxisome Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Cellular Response To Reactive Oxygen Species Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release
Pathways		Platelet degranulation	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Glycemic traits (pregnancy) ( 23903356) Hemoglobin levels ( 32327693)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		17 interacting genes: ALB BAG6 CCL3 CD44 CEP70 FHL3 GZMB NCALD PEX12 PF4 PSRC1 SGTA SGTB UBQLN1 UBQLN2 UBQLN4 UBR4	36 interacting genes: ACSL5 ADIPOQ BNIP2 BTN2A2 C5orf46 CLDN10 COL8A2 CXCL16 CYBC1 DNAJC30 ERMP1 FA2H FKBP8 FXYD6 GJB2 IER3IP1 MARCHF2 MGLL NKG7 NRM PEX10 PEX19 PEX5 PNLIPRP1 PTPN9 RBFA SEC22A SEC61G SMCO4 SRGN STX8 THSD7B TMEM11 TMEM222 TREX1 TTPA
Entrez ID		5552	5193
HPRD ID		01513	03455
Ensembl ID		ENSG00000122862	ENSG00000108733
Uniprot IDs		P10124	O00623
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Proteolysis Involved In Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRC Complex Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Macromolecule Catabolic Process Protein Targeting To ER Response To Stress Proteasomal Protein Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Identical Protein Binding Establishment Of Protein Localization To Organelle Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Targeting To Membrane Positive Regulation Of Protein Catabolic Process Cellular Response To Stress Autophagosome Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Catabolic Process Cytosol Autophagy Catabolic Process Monocyte Chemotaxis Organelle Organization Protein Insertion Into ER Membrane Regulation Of Autophagy Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Cytokine-mediated Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Molecular Adaptor Activity Regulation Of Macroautophagy Negative Regulation Of Store-operated Calcium Channel Activity Establishment Of Protein Localization Hsp70 Protein Binding	Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Peroxisome Membrane Targeting Sequence Binding Endoplasmic Reticulum Membrane Membrane Peroxisome Organization Intracellular Protein Transmembrane Transport Fatty Acid Metabolic Process Endoplasmic Reticulum Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Targeting To Peroxisome Protein Carrier Chaperone Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Protein Unfolding Peroxisomal Membrane Protein Import Into Peroxisome Matrix Monocarboxylic Acid Metabolic Process Protein Transmembrane Transport Pexophagy Triglyceride Catabolic Process Response To Oxidative Stress Cellular Response To Oxidative Stress Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Protein Transmembrane Transporter Activity Receptor Recycling Cellular Response To Reactive Oxygen Species Fatty Acid Biosynthetic Process Acylglycerol Catabolic Process Lipid Catabolic Process Maintenance Of Granzyme B Location In T Cell Secretory Granule Maintenance Of Protease Location In Mast Cell Secretory Granule T Cell Secretory Granule Organization Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Membrane Organization Negative Regulation Of Establishment Of Blood-brain Barrier Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Ssh1 Translocon Complex 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Fatty Acid 2-hydroxylase Activity
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