SRGN and GZMB

Number of citations: 0 (PubMedID 10228010)
Data Source: HPRD (in vitro)

		SRGN	GZMB
Name		serglycin	granzyme B
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Golgi Apparatus Secretory Granule Extracellular Matrix Platelet Alpha Granule Lumen Mast Cell Granule Cytolytic Granule	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Cytolytic Granule Cytolytic Granule Lumen
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Cytokine Production Apoptotic Process Protein Processing Negative Regulation Of Bone Mineralization Biomineral Tissue Development Secretory Granule Organization Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Granzyme-mediated Programmed Cell Death Signaling Pathway	Plasma Membrane Repair Positive Regulation Of Immune Response To Tumor Cell Proteolysis Apoptotic Process Protein Secretion Negative Regulation Of Translation Killing Of Cells Of Another Organism Natural Killer Cell Mediated Cytotoxicity Ceramide Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Pathways		Platelet degranulation	NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria Nuclear events stimulated by ALK signaling in cancer
GWAS		Glycemic traits (pregnancy) ( 23903356 ) Hemoglobin levels ( 32327693 )	Blood protein levels ( 30072576 ) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189 ) Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683 ) Vitiligo ( 20410501 27723757 )
Novel Interactors		None recorded	1 novel interactors: NEK9
Interacting Genes		17 interacting genes: ALB BAG6 CCL3 CD44 CEP70 FHL3 GZMB NCALD PEX12 PF4 PSRC1 SGTA SGTB UBQLN1 UBQLN2 UBQLN4 UBR4	26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		5552	3002
HPRD ID		01513	00476
Ensembl ID		ENSG00000122862	ENSG00000100453
Uniprot IDs		P10124	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs		Not available	1FQ3 1IAU
GO Terms Enriched among Interactors		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Proteolysis Involved In Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRC Complex Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Macromolecule Catabolic Process Protein Targeting To ER Response To Stress Proteasomal Protein Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Identical Protein Binding Establishment Of Protein Localization To Organelle Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Targeting To Membrane Positive Regulation Of Protein Catabolic Process Cellular Response To Stress Autophagosome Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Catabolic Process Cytosol Autophagy Catabolic Process Monocyte Chemotaxis Organelle Organization Protein Insertion Into ER Membrane Regulation Of Autophagy Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Cytokine-mediated Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Molecular Adaptor Activity Regulation Of Macroautophagy Negative Regulation Of Store-operated Calcium Channel Activity Establishment Of Protein Localization Hsp70 Protein Binding	DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Response To Radiation Positive Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Regulation Of Programmed Cell Death DNA-dependent Protein Kinase Complex Apoptotic Process Regulation Of Apoptotic Process Response To Anesthetic Response To Ionizing Radiation Cellular Response To Stress Protein Processing Protein Maturation Response To Cobalt Ion Telomere Maintenance Pyroptotic Inflammatory Response Fibroblast Apoptotic Process Protein-DNA Complex Neuron Apoptotic Process Granzyme-mediated Programmed Cell Death Signaling Pathway Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Response To Gamma Radiation Protein-containing Complex Telomere Organization Regulation Of Neuron Apoptotic Process Death Receptor Binding Double-strand Break Repair Via Nonhomologous End Joining Structural Constituent Of Nuclear Lamina Response To Stress Protein Poly-ADP-ribosylation Cysteine-type Endopeptidase Activity Response To UV Positive Regulation Of Neuron Apoptotic Process Enzyme Activator Activity Macromolecule Metabolic Process DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Chromosome, Telomeric Region Execution Phase Of Apoptosis Response To Light Stimulus Regulation Of Immune Response Apoptotic Signaling Pathway Response To Metal Ion Immune System Process Response To X-ray Regulation Of Immune System Process