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CCND1 and TP73
Number of citations of the paper that reports this interaction (PubMedID
12676926
)
0
Data Source:
BioGRID
(pull down)
CCND1
TP73
Description
cyclin D1
tumor protein p73
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Bicellular Tight Junction
Membrane
Transcription Repressor Complex
Nuclear Membrane
Cyclin D1-CDK4 Complex
Cyclin D1-CDK6 Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Cell Junction
Ciliary Basal Body
Molecular Function
Transcription Corepressor Activity
Protein Kinase Activity
Protein Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Enzyme Binding
Protein Kinase Binding
Histone Deacetylase Binding
Protein Serine/threonine Kinase Activator Activity
Protein-containing Complex Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Proline-rich Region Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
MDM2/MDM4 Family Protein Binding
DNA-binding Transcription Factor Binding
Promoter-specific Chromatin Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Re-entry Into Mitotic Cell Cycle
Liver Development
DNA Damage Response
Lactation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Iron Ion
Response To X-ray
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Wnt Signaling Pathway
Neuron Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Endoplasmic Reticulum Unfolded Protein Response
Animal Organ Regeneration
Mitotic G1 DNA Damage Checkpoint Signaling
Response To Magnesium Ion
Response To Estradiol
Response To Vitamin E
Leydig Cell Differentiation
Mammary Gland Epithelial Cell Proliferation
Positive Regulation Of Mammary Gland Epithelial Cell Proliferation
Negative Regulation Of Neuron Apoptotic Process
Response To Estrogen
Response To Leptin
Fat Cell Differentiation
Response To Ethanol
Response To Steroid Hormone
Cell Division
Response To Glucocorticoid
Response To Corticosterone
Response To Calcium Ion
Regulation Of Cell Cycle
Mammary Gland Alveolus Development
Response To UV-A
Liver Regeneration
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Kidney Development
Release Of Cytochrome C From Mitochondria
Mismatch Repair
Regulation Of DNA-templated Transcription
Apoptotic Process
Inflammatory Response
DNA Damage Response
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Post-embryonic Development
Regulation Of Gene Expression
Hippocampus Development
Forebrain Development
Cerebrospinal Fluid Secretion
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Cell Size
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Morphogenesis
Neuron Development
Positive Regulation Of Oligodendrocyte Differentiation
Protein Tetramerization
Regulation Of Cell Cycle
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Lung Ciliated Cell Differentiation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
SCF(Skp2)-mediated degradation of p27/p21
Pre-NOTCH Transcription and Translation
RMTs methylate histone arginines
Interleukin-4 and Interleukin-13 signaling
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional Regulation by VENTX
Transcriptional regulation by RUNX2
Regulation of RUNX1 Expression and Activity
RUNX3 regulates WNT signaling
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drug-mediated inhibition of CDK4/CDK6 activity
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Acetylsalicylic acid
Arsenic trioxide
Encorafenib
Bryostatin 1
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Breast cancer
Hairy-cell leukemia
Oral cancer
Multiple myeloma
Laryngeal cancer
von Hippel-Lindau syndrome
Esophageal cancer
Hepatocellular carcinoma
GWAS
Adult body size (
32376654
)
Birth weight (
31043758
)
Blond vs. brown/black hair color (
30531825
)
Body fat distribution (arm fat ratio) (
30664634
)
Breast cancer (
20453838
29059683
)
Breast cancer (early onset) (
24493630
)
Breast size (
22747683
27182965
)
Cerebral microbleeds (
32913026
)
Craniofacial microsomia (
26853712
)
Cutaneous malignant melanoma (
26237428
32341527
)
Diastolic blood pressure (
27841878
)
Height (
25429064
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Idiopathic dilated cardiomyopathy (
29495422
)
Immunoglobulin light chain (AL) amyloidosis (
28025584
)
Melanoma (
28212542
)
Multiple myeloma (IgH translocation) (
23502783
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Offspring birth weight (
31043758
)
Refractive error (
32231278
)
Total body bone mineral density (
29304378
)
Type 2 diabetes (
32499647
30718926
30297969
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
White blood cell count (
32888494
)
Joint damage in rheumatoid arthritis (
31596875
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Visceral fat (
22589738
)
Waist-hip ratio (
28552196
)
Interacting Genes
82 interacting genes:
AKAP8
AMBRA1
AR
ARID4A
ATF2
BCAS3
BRCA1
BRCA2
BRINP1
BTRC
CALM1
CAMK1
CCNDBP1
CDC14B
CDH13
CDK4
CDK6
CDK8
CDKN1A
CDKN1B
CRYAB
CTNNB1
CUL3
DMTF1
DZIP3
EP300
ESR1
FANCC
FBXO31
FBXO4
FOS
GSK3B
HDAC3
HERC5
IFI27
IGFBP3
INSM1
JUN
JUND
KAT2B
KLK7
KLK9
LPL
MAPK11
MCM10
MCM7
MYBL2
NCOA1
NCOA3
NPDC1
ORC4
PCNA
POLR1B
PPP3R2
PRKACA
PRKN
RABEP1
RAD51
RANBP9
RB1
RBL1
RBL2
RBX1
RFC1
RUNX1
SMAD1
SP1
STAT3
TAF1
TBC1D2
TDRD7
THRA
THRB
TP73
TRMO
TSC2
TSTD2
UBTF
UHRF2
USP13
XPO1
ZNF510
64 interacting genes:
ABL1
ATF3
AURKA
BIN1
BUB1B
CABLES1
CCNB1
CCND1
CCNE1
CDK1
CDK2
CEBPZ
CHD3
CREBBP
CSNK2A1
DAXX
DDB1
EP300
FBXO45
FLNA
HCK
HECW2
HIPK2
HIPK3
HMGB1
HRAS
IKBKB
ITCH
KAT2B
MAPK8
MDM2
MDM4
MUL1
MYC
NEDD4
NFYB
PFDN5
PIAS1
PIN1
PLK1
PML
PPP1R13B
PRKACB
RACK1
RANBP9
RCHY1
RPL11
RPL5
SIRT1
SMAD2
SMAD3
SP1
SP3
STUB1
SUMO1
TP53
TP63
TRIM28
UBE2I
UBE3C
WT1
WWOX
XPO1
YAP1
Entrez ID
595
7161
HPRD ID
01346
03587
Ensembl ID
ENSG00000110092
ENSG00000078900
Uniprot IDs
P24385
Q6FI00
A0A0C4DFW9
O15350
PDB IDs
2W96
2W99
2W9F
2W9Z
5VZU
6P8E
6P8F
6P8G
6P8H
1COK
1DXS
2KBY
2MPS
2NB1
2WQI
2WQJ
2WTT
2XWC
3VD0
3VD1
3VD2
4A63
4G82
4G83
4GUO
4GUQ
5HOB
5HOC
5KBD
6FGS
6IJQ
7EZJ
8P9C
8P9D
8P9E
9GLQ
9GNB
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Regulation Of Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Biosynthetic Process
Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
DNA-templated Transcription
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Cell Population Proliferation
Cellular Response To Stress
Positive Regulation Of RNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Response To Hormone
DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Biosynthetic Process
Cyclin Binding
Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of RNA Metabolic Process
Cellular Response To Hormone Stimulus
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Transcription Regulator Complex
Nucleic Acid Metabolic Process
Ubiquitin Protein Ligase Binding
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Nucleoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Nucleus
Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Gene Expression
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
DNA Damage Response
Protein Modification Process
Negative Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
Protein Metabolic Process
Post-translational Protein Modification
Regulation Of Protein Stability
Response To Stress
Regulation Of Proteolysis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
PML Body
Ubiquitin Protein Ligase Binding
Positive Regulation Of RNA Metabolic Process
Apoptotic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Enzyme Binding
Regulation Of Cellular Component Organization
P53 Binding
DNA-binding Transcription Factor Binding
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