CCND1 and CRYAB

Number of citations of the paper that reports this interaction (PMID 17081987)
99

Data Source:
BioGRID (pull down)

		CCND1	CRYAB
Gene Name		cyclin D1	crystallin, alpha B
Image
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Intracellular Nucleus Nucleoplasm Cytosol Tight Junction Membrane Transcriptional Repressor Complex	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Z Disc Actin Filament Bundle Extracellular Vesicular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Protein Complex Binding Histone Deacetylase Binding Proline-rich Region Binding	Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Unfolded Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Re-entry Into Mitotic Cell Cycle Liver Development Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus Notch Signaling Pathway Lactation Response To Iron Ion Response To X-ray Response To Organonitrogen Compound Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Organ Regeneration Mitotic G1 DNA Damage Checkpoint Response To Magnesium Ion Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Drug Response To Estrogen Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Response To Corticosterone Response To Calcium Ion Canonical Wnt Signaling Pathway Mammary Gland Alveolus Development Response To UV-A Negative Regulation Of Cell Cycle Arrest	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Homooligomerization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Chromatin organization Signaling by NOTCH Ubiquitin-dependent degradation of Cyclin D G1 Phase S Phase Cell Cycle, Mitotic RMTs methylate histone arginines Ubiquitin-dependent degradation of Cyclin D1 Cyclin D associated events in G1 Chromatin modifying enzymes Pre-NOTCH Transcription and Translation Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases
Drugs		Arsenic trioxide
Diseases
GWAS		Breast cancer ( 20453838) Breast size ( 22747683) Multiple myeloma (IgH translocation) ( 23502783)
Protein-Protein Interactions		60 interactors: AKAP8 AR ARID4A ATF2 BRCA1 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CRYAB CTNNB1 CUL3 DMTF1 EP300 ESR1 FBXO31 FBXO4 GSK3B HDAC3 HERC5 IFI27 INSM1 KAT2B LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PRKACA RABEP1 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SP1 STAT3 TAF1 THRA THRB TP73 TSC2 UBTF UHRF2 USP2 XPO1	44 interactors: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CS DDX20 DES EPB41 FCGR2A FGF2 GFAP HBA1 HSPB1 HSPB2 HSPB8 INS KRTAP19-5 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PSMA3 SNCA SOD1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		595	1410
HPRD ID		01346	00428
Ensembl ID		ENSG00000110092	ENSG00000109846
Uniprot IDs		P24385 Q6FI00	P02511
PDB IDs		2W96 2W99 2W9F 2W9Z	2KLR 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Organic Substance Cellular Response To Organic Substance Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Gene Expression Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cell Cycle Arrest Transcription, DNA-templated Cellular Response To Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Kinase Activity RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Kinase Activity Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process	Response To Stress Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To External Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Lipid Metabolic Process Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of Growth Response To Wounding Neuron Apoptotic Process Camera-type Eye Development Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of Neuron Apoptotic Process Regulation Of Lipid Biosynthetic Process Organ Development Neuron Death Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Eye Development Programmed Cell Death Sensory Organ Development Response To Oxidative Stress Platelet Degranulation Sensory Perception
Tagcloud ?		11q13 4nqo 7f4 amplicon amplification amplified cavity chr distal example fgf3 fgf4 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold	adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide
Tagcloud (Difference) ?		11q13 4nqo 7f4 amplicon amplification amplified cavity chr distal example fgf3 fgf4 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold	adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide
Tagcloud (Intersection) ?