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CCND1 and RABEP1
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
CCND1
RABEP1
Description
cyclin D1
rabaptin, RAB GTPase binding effector protein 1
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Bicellular Tight Junction
Membrane
Transcription Repressor Complex
Nuclear Membrane
Cyclin D1-CDK4 Complex
Cyclin D1-CDK6 Complex
Cytoplasm
Endosome
Early Endosome
Cytosol
Endocytic Vesicle
Cytoplasmic Vesicle
Early Endosome Membrane
Protein-containing Complex
Recycling Endosome
Glutamatergic Synapse
Molecular Function
Transcription Corepressor Activity
Protein Kinase Activity
Protein Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Enzyme Binding
Protein Kinase Binding
Histone Deacetylase Binding
Protein Serine/threonine Kinase Activator Activity
Protein-containing Complex Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Proline-rich Region Binding
GTPase Activator Activity
Protein Binding
Growth Factor Activity
Protein Domain Specific Binding
Protein Homodimerization Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Re-entry Into Mitotic Cell Cycle
Liver Development
DNA Damage Response
Lactation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Iron Ion
Response To X-ray
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Wnt Signaling Pathway
Neuron Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Endoplasmic Reticulum Unfolded Protein Response
Animal Organ Regeneration
Mitotic G1 DNA Damage Checkpoint Signaling
Response To Magnesium Ion
Response To Estradiol
Response To Vitamin E
Leydig Cell Differentiation
Mammary Gland Epithelial Cell Proliferation
Positive Regulation Of Mammary Gland Epithelial Cell Proliferation
Negative Regulation Of Neuron Apoptotic Process
Response To Estrogen
Response To Leptin
Fat Cell Differentiation
Response To Ethanol
Response To Steroid Hormone
Cell Division
Response To Glucocorticoid
Response To Corticosterone
Response To Calcium Ion
Regulation Of Cell Cycle
Mammary Gland Alveolus Development
Response To UV-A
Liver Regeneration
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Golgi To Plasma Membrane Transport
Endocytosis
Apoptotic Process
Signal Transduction
Protein Transport
Vesicle-mediated Transport
Membrane Fusion
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Protein Localization To Ciliary Membrane
Pathways
SCF(Skp2)-mediated degradation of p27/p21
Pre-NOTCH Transcription and Translation
RMTs methylate histone arginines
Interleukin-4 and Interleukin-13 signaling
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional Regulation by VENTX
Transcriptional regulation by RUNX2
Regulation of RUNX1 Expression and Activity
RUNX3 regulates WNT signaling
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drug-mediated inhibition of CDK4/CDK6 activity
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
SPOP-mediated proteasomal degradation of PD-L1(CD274)
TBC/RABGAPs
Drugs
Acetylsalicylic acid
Arsenic trioxide
Encorafenib
Bryostatin 1
Diseases
Breast cancer
Hairy-cell leukemia
Oral cancer
Multiple myeloma
Laryngeal cancer
von Hippel-Lindau syndrome
Esophageal cancer
GWAS
Adult body size (
32376654
)
Birth weight (
31043758
)
Blond vs. brown/black hair color (
30531825
)
Body fat distribution (arm fat ratio) (
30664634
)
Breast cancer (
20453838
29059683
)
Breast cancer (early onset) (
24493630
)
Breast size (
22747683
27182965
)
Cerebral microbleeds (
32913026
)
Craniofacial microsomia (
26853712
)
Cutaneous malignant melanoma (
26237428
32341527
)
Diastolic blood pressure (
27841878
)
Height (
25429064
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Idiopathic dilated cardiomyopathy (
29495422
)
Immunoglobulin light chain (AL) amyloidosis (
28025584
)
Melanoma (
28212542
)
Multiple myeloma (IgH translocation) (
23502783
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Offspring birth weight (
31043758
)
Refractive error (
32231278
)
Total body bone mineral density (
29304378
)
Type 2 diabetes (
32499647
30718926
30297969
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
White blood cell count (
32888494
)
Body mass index (
25673413
28892062
)
Lymphocyte count (
32888494
)
Mean platelet volume (
32888494
)
Red blood cell density in sickle cell anemia (
28552477
)
White blood cell count (
27863252
)
Interacting Genes
82 interacting genes:
AKAP8
AMBRA1
AR
ARID4A
ATF2
BCAS3
BRCA1
BRCA2
BRINP1
BTRC
CALM1
CAMK1
CCNDBP1
CDC14B
CDH13
CDK4
CDK6
CDK8
CDKN1A
CDKN1B
CRYAB
CTNNB1
CUL3
DMTF1
DZIP3
EP300
ESR1
FANCC
FBXO31
FBXO4
FOS
GSK3B
HDAC3
HERC5
IFI27
IGFBP3
INSM1
JUN
JUND
KAT2B
KLK7
KLK9
LPL
MAPK11
MCM10
MCM7
MYBL2
NCOA1
NCOA3
NPDC1
ORC4
PCNA
POLR1B
PPP3R2
PRKACA
PRKN
RABEP1
RAD51
RANBP9
RB1
RBL1
RBL2
RBX1
RFC1
RUNX1
SMAD1
SP1
STAT3
TAF1
TBC1D2
TDRD7
THRA
THRB
TP73
TRMO
TSC2
TSTD2
UBTF
UHRF2
USP13
XPO1
ZNF510
60 interacting genes:
ABI2
AIMP2
AP1G1
AP1G2
ATXN7
BARD1
CASP3
CCDC120
CCND1
CDC73
CDK18
CDKL3
CEP57
CFAP53
ELOA
ESCO2
FAM50B
FAM90A1
GAP43
GGA1
GGA2
GGA3
HUNK
ITSN1
LENG1
MAT2B
MCRS1
NRIP1
ODAD3
PELI2
PKP2
PRPF3
RAB1A
RAB33B
RAB4A
RAB4B
RAB5A
RABGEF1
RGS17
RNF39
SMURF1
SNAPIN
SNCA
SNW1
SRPK2
STAR
TNS4
TRAPPC2L
TRIM26
TSC2
TSHZ2
UBC
UBTFL1
USP2
UTP14C
WASHC3
YWHAG
ZNF438
ZNF512B
ZNF774
Entrez ID
595
9135
HPRD ID
01346
04684
Ensembl ID
ENSG00000110092
ENSG00000029725
Uniprot IDs
P24385
Q6FI00
B4DMM4
Q15276
PDB IDs
2W96
2W99
2W9F
2W9Z
5VZU
6P8E
6P8F
6P8G
6P8H
1P4U
1TU3
1X79
4N3Y
4N3Z
4Q9U
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Regulation Of Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Biosynthetic Process
Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
DNA-templated Transcription
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Cell Population Proliferation
Cellular Response To Stress
Positive Regulation Of RNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Response To Hormone
DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Biosynthetic Process
Cyclin Binding
Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of RNA Metabolic Process
Cellular Response To Hormone Stimulus
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Transcription Regulator Complex
Nucleic Acid Metabolic Process
Ubiquitin Protein Ligase Binding
Negative Regulation Of Macromolecule Metabolic Process
Intracellular Protein Localization
Vesicle-mediated Transport
Golgi Vesicle Transport
Protein Binding
Early Endosome Membrane
Protein Transport
Establishment Of Protein Localization
Endosome
Intracellular Transport
Regulation Of Vesicle-mediated Transport
G Protein Activity
Recycling Endosome
Cellular Localization
Establishment Of Localization In Cell
Vesicle-mediated Transport In Synapse
Intracellular Protein Transport
Rab Protein Signal Transduction
Post-Golgi Vesicle-mediated Transport
Endosomal Transport
Intracellular Vesicle
Regulation Of Exocytosis
Small GTPase Binding
Positive Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
GTPase Activity
Early Endosome
Post-translational Protein Modification
Protein Localization To Cell Surface
Presynapse
Insulin-responsive Compartment
Negative Regulation Of Exocytosis
Golgi To Plasma Membrane Protein Transport
Vacuolar Transport
Synaptic Vesicle Endocytosis
Cytoplasmic Vesicle Membrane
Protein Localization To Organelle
Nucleus
Secretion
Protein Modification Process
Secretion By Cell
Protein Polyubiquitination
Presynaptic Endocytosis
Regulation Of MRNA 3'-end Processing
Endosome Membrane
Protein Localization To Plasma Membrane
Positive Regulation Of Translational Initiation
Regulation Of Endosome Size
Regulation Of Cellular Component Organization
Exocytosis
AP-1 Adaptor Complex
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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