CCND1 and USP13

Number of citations: 42 (PubMedID 37311811)
Data Source: BioGRID (pull down)

		CCND1	USP13
Name		cyclin D1	ubiquitin specific peptidase 13
Structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Bicellular Tight Junction Membrane Transcription Repressor Complex Nuclear Membrane Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Proline-rich Region Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Protein-folding Chaperone Binding Proteasome Binding BAT3 Complex Binding K48-linked Deubiquitinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Re-entry Into Mitotic Cell Cycle Liver Development DNA Damage Response Lactation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Iron Ion Response To X-ray Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Animal Organ Regeneration Mitotic G1 DNA Damage Checkpoint Signaling Response To Magnesium Ion Response To Estradiol Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Response To Leptin Fat Cell Differentiation Response To Ethanol Response To Steroid Hormone Cell Division Response To Glucocorticoid Response To Corticosterone Response To Calcium Ion Regulation Of Cell Cycle Mammary Gland Alveolus Development Response To UV-A Liver Regeneration Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of DNA-templated Transcription Proteolysis Autophagy Cell Population Proliferation Regulation Of Autophagy Protein Deubiquitination Melanocyte Differentiation Regulation Of Protein Stability Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein Protein K6-linked Deubiquitination Protein Stabilization Protein K63-linked Deubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Pre-NOTCH Transcription and Translation RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity Regulation of MITF-M-dependent genes involved in cell cycle and proliferation SPOP-mediated proteasomal degradation of PD-L1(CD274)	Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs		Acetylsalicylic acid Arsenic trioxide Encorafenib Bryostatin 1	None
Diseases		Breast cancer Hairy-cell leukemia Oral cancer Multiple myeloma Laryngeal cancer von Hippel-Lindau syndrome Esophageal cancer	None
GWAS		Adult body size ( 32376654 ) Birth weight ( 31043758 ) Blond vs. brown/black hair color ( 30531825 ) Body fat distribution (arm fat ratio) ( 30664634 ) Breast cancer ( 20453838 29059683 ) Breast cancer (early onset) ( 24493630 ) Breast size ( 22747683 27182965 ) Cerebral microbleeds ( 32913026 ) Craniofacial microsomia ( 26853712 ) Cutaneous malignant melanoma ( 26237428 32341527 ) Diastolic blood pressure ( 27841878 ) Height ( 25429064 ) Hip circumference ( 25673412 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Immunoglobulin light chain (AL) amyloidosis ( 28025584 ) Melanoma ( 28212542 ) Multiple myeloma (IgH translocation) ( 23502783 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Offspring birth weight ( 31043758 ) Refractive error ( 32231278 ) Total body bone mineral density ( 29304378 ) Type 2 diabetes ( 32499647 30718926 30297969 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 )	No GWAS studies recorded
Interacting Genes		82 interacting genes: AKAP8 AMBRA1 AR ARID4A ATF2 BCAS3 BRCA1 BRCA2 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDC14B CDH13 CDK4 CDK6 CDK8 CDKN1A CDKN1B CRYAB CTNNB1 CUL3 DMTF1 DZIP3 EP300 ESR1 FANCC FBXO31 FBXO4 FOS GSK3B HDAC3 HERC5 IFI27 IGFBP3 INSM1 JUN JUND KAT2B KLK7 KLK9 LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PPP3R2 PRKACA PRKN RABEP1 RAD51 RANBP9 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SMAD1 SP1 STAT3 TAF1 TBC1D2 TDRD7 THRA THRB TP73 TRMO TSC2 TSTD2 UBTF UHRF2 USP13 XPO1 ZNF510	25 interacting genes: AMFR ATG5 CCND1 CLK3 CSNK2A1 CTNNB1 DAZAP2 DVL1 DYRK1A FNBP1L FUNDC2 G3BP1 LAPTM5 MDC1 MRPL20 MYO15A SIAH2 SPRR2C TOPBP1 TRIM55 TRIM63 TWIST1 UBC UBL4A UIMC1
Entrez ID		595	8975
HPRD ID		01346	04666
Ensembl ID		ENSG00000110092	ENSG00000058056
Uniprot IDs		P24385 Q6FI00	A0A0A6YZ17 Q92995
PDB IDs		2W96 2W99 2W9F 2W9Z 5VZU 6P8E 6P8F 6P8G 6P8H	2L80 2LBC
GO Terms Enriched among Interactors		Nucleoplasm Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Population Proliferation Cellular Response To Stress Positive Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Hormone DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Cyclin Binding Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of RNA Metabolic Process Cellular Response To Hormone Stimulus G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Transcription Regulator Complex Nucleic Acid Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process	DNA Damage Checkpoint Signaling Protein Modification Process Wnt Signaling Pathway Protein Ubiquitination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Autophagic Cell Death Autophagy Protein Localization To Site Of Double-strand Break Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Intracellular Signal Transduction Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Protein Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Negative Regulation Of Signal Transduction By P53 Class Mediator Post-translational Protein Modification Response To Stress Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Cycle Process Identical Protein Binding Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Stress Granule Assembly Ubiquitin Protein Ligase Binding Regulation Of DNA Metabolic Process Genitalia Morphogenesis Regulation Of Wnt Signaling Pathway Cellular Response To Stress Negative Regulation Of Wnt Signaling Pathway Wnt Signalosome Cardiac Muscle Cell Apoptotic Process Catabolic Process Protein Serine/threonine Kinase Activator Activity Nucleus Aggrephagy Striated Muscle Cell Apoptotic Process Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Protein-containing Complex Macromolecule Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Catabolic Process