TBC1D2 and MLH3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		TBC1D2	MLH3
Description		TBC1 domain family member 2	mutL homolog 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cytoplasmic Vesicle Anchoring Junction	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	GTPase Activator Activity Protein Binding Cadherin Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Positive Regulation Of GTPase Activity Regulation Of Cilium Assembly	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization
Pathways		TBC/RABGAPs	Meiotic recombination
Drugs
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Post-traumatic stress disorder ( 26114229) Rate of ventricular enlargement ( 31711042) Severe influenza A (H1N1) infection ( 26379185)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: AURKA BUB1 CCND1 DCC GABARAPL1 KCTD6 MAP1LC3A MLH3 PDGFRL UBC	48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		55357	27030
HPRD ID		11624	05094
Ensembl ID		ENSG00000095383	ENSG00000119684
Uniprot IDs		Q9BYX2	Q2M1Z1 Q9UHC1
PDB IDs		2DHK
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Liver Regeneration Response To Iron Ion Positive Regulation Of Cell Cycle Process Animal Organ Regeneration Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Mitophagy Autophagosome Maturation Autophagosome Membrane Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Positive Regulation Of Cell Cycle Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Microtubule Autophagy Of Mitochondrion Autophagosome Chiasma Microtubule Organizing Center Response To Nutrient Levels Re-entry Into Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Liver Development Cytosol Regulation Of Mitotic Nuclear Division Meiotic Sister Chromatid Cohesion, Centromeric Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Platelet Activating Factor Receptor Activity Macromolecule Catabolic Process Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Positive Regulation Of Oocyte Maturation Autophagosome Organization Phospholipid Binding Autophagosome Assembly Satellite DNA Binding Cellular Response To Oxygen-glucose Deprivation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Kinase Activity Regeneration	Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration
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