TBC1D2 and PDGFRL

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		TBC1D2	PDGFRL
Description		TBC1 domain family member 2	platelet derived growth factor receptor like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cytoplasmic Vesicle Anchoring Junction	Extracellular Region
	Molecular Function	GTPase Activator Activity Protein Binding Cadherin Binding	Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity
	Biological Process	Positive Regulation Of GTPase Activity Regulation Of Cilium Assembly	G Protein-coupled Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway
Pathways		TBC/RABGAPs
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Post-traumatic stress disorder ( 26114229) Rate of ventricular enlargement ( 31711042) Severe influenza A (H1N1) infection ( 26379185)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hippocampal volume in normal cognition ( 29274321) Placental abruption ( 29884306) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma parathyroid hormone levels ( 30134803) Spatial memory ( 31596458) Sphingomyelin 24:0 levels ( 31560688)
Interacting Genes		10 interacting genes: AURKA BUB1 CCND1 DCC GABARAPL1 KCTD6 MAP1LC3A MLH3 PDGFRL UBC	24 interacting genes: ASPH BAAT CCDC180 CTSV FANCC FBP2 HRAS MAP2K1 MAPK12 MAPK3 MBP NANS PFKM PPP2CB PPP3R2 RANGAP1 SFRP4 SMAD1 SPARCL1 TBC1D2 TGFB1 TMEM129 XPA ZNF510
Entrez ID		55357	5157
HPRD ID		11624	05206
Ensembl ID		ENSG00000095383	ENSG00000104213
Uniprot IDs		Q9BYX2	Q15198
PDB IDs		2DHK
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Liver Regeneration Response To Iron Ion Positive Regulation Of Cell Cycle Process Animal Organ Regeneration Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Mitophagy Autophagosome Maturation Autophagosome Membrane Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Positive Regulation Of Cell Cycle Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Microtubule Autophagy Of Mitochondrion Autophagosome Chiasma Microtubule Organizing Center Response To Nutrient Levels Re-entry Into Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Liver Development Cytosol Regulation Of Mitotic Nuclear Division Meiotic Sister Chromatid Cohesion, Centromeric Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Platelet Activating Factor Receptor Activity Macromolecule Catabolic Process Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Positive Regulation Of Oocyte Maturation Autophagosome Organization Phospholipid Binding Autophagosome Assembly Satellite DNA Binding Cellular Response To Oxygen-glucose Deprivation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Kinase Activity Regeneration	Myelination Axon Ensheathment MAPK Cascade Regulation Of Intracellular Transport Glial Cell Development Schwann Cell Development Regulation Of Cellular Localization Regulation Of Golgi Inheritance Intracellular Signaling Cassette Trachea Formation Regulation Of Intracellular Protein Transport Fructose 1,6-bisphosphate Metabolic Process ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Catalytic Activity Bergmann Glial Cell Differentiation Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of ERK1 And ERK2 Cascade Chemical Homeostasis Cytosol Fructose 6-phosphate Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of Cell-cell Adhesion Regulation Of Transport Regulation Of Protein Localization MAP Kinase Activity Positive Regulation Of Intracellular Protein Transport Regulation Of MiRNA Metabolic Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Homeostatic Process Negative Regulation Of Transport Regulation Of Protein Transport Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Protein Transport Animal Organ Formation Face Development Negative Regulation Of Cell Population Proliferation ERBB2 Signaling Pathway Intracellular Signal Transduction Gland Development Positive Regulation Of Hydrolase Activity Muscle Cell Cellular Homeostasis Regulation Of Protein Localization To Synapse Lung Morphogenesis
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