TBC1D2 and KCTD6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D2	KCTD6
Description		TBC1 domain family member 2	potassium channel tetramerization domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cytoplasmic Vesicle Anchoring Junction	Cytoplasm Cytosol M Band
	Molecular Function	GTPase Activator Activity Protein Binding Cadherin Binding	Protein Binding Ankyrin Binding Identical Protein Binding Cullin Family Protein Binding
	Biological Process	Positive Regulation Of GTPase Activity Regulation Of Cilium Assembly	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization
Pathways		TBC/RABGAPs	RUNX1 regulates estrogen receptor mediated transcription Neddylation Estrogen-dependent gene expression Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Post-traumatic stress disorder ( 26114229) Rate of ventricular enlargement ( 31711042) Severe influenza A (H1N1) infection ( 26379185)	Hepcidin/transferrin saturation ratio ( 27846281) Refractive error ( 32231278) Systemic lupus erythematosus ( 28714469) vWF levels ( 30586737)
Interacting Genes		10 interacting genes: AURKA BUB1 CCND1 DCC GABARAPL1 KCTD6 MAP1LC3A MLH3 PDGFRL UBC	26 interacting genes: ACTN1 ACTN3 ANK1 BAG4 C8orf33 CDC23 CTNND1 ERBB2 FAM124B GOLGA8EP GOLGA8F GRB7 GSDMD LNX1 MOS NTAQ1 PICK1 PPIG PRPF31 PSMA1 REL SDCBP TBC1D2 TCEANC TEPSIN ZCCHC10
Entrez ID		55357	200845
HPRD ID		11624	13769
Ensembl ID		ENSG00000095383	ENSG00000168301
Uniprot IDs		Q9BYX2	Q8NC69
PDB IDs		2DHK
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Liver Regeneration Response To Iron Ion Positive Regulation Of Cell Cycle Process Animal Organ Regeneration Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Mitophagy Autophagosome Maturation Autophagosome Membrane Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Positive Regulation Of Cell Cycle Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Microtubule Autophagy Of Mitochondrion Autophagosome Chiasma Microtubule Organizing Center Response To Nutrient Levels Re-entry Into Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Liver Development Cytosol Regulation Of Mitotic Nuclear Division Meiotic Sister Chromatid Cohesion, Centromeric Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Platelet Activating Factor Receptor Activity Macromolecule Catabolic Process Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Positive Regulation Of Oocyte Maturation Autophagosome Organization Phospholipid Binding Autophagosome Assembly Satellite DNA Binding Cellular Response To Oxygen-glucose Deprivation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Kinase Activity Regeneration
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