PPP2R3A and ATR

Number of citations of the paper that reports this interaction (PubMedID 10608806)
0

Data Source:
BioGRID (unspecified method)

		PPP2R3A	ATR
Description		protein phosphatase 2 regulatory subunit B''alpha	ATR checkpoint kinase
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex	Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Chromosome Golgi Apparatus PML Body ATR-ATRIP Complex Site Of DNA Damage
	Molecular Function	Calcium Ion Binding Protein Binding Protein Phosphatase Regulator Activity Protein-macromolecule Adaptor Activity Metal Ion Binding	Nucleotide Binding DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MutLalpha Complex Binding MutSalpha Complex Binding Histone H2AXS139 Kinase Activity Protein Serine Kinase Activity
	Biological Process	Eye Photoreceptor Cell Differentiation Somitogenesis Protein Dephosphorylation Somatic Muscle Development Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Somite Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Migration Involved In Somitogenic Axis Elongation Positive Regulation Of Canonical Wnt Signaling Pathway	DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair Double-strand Break Repair Chromatin Remodeling DNA Damage Response Nuclear Envelope Organization Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Response To Mechanical Stimulus Replication Fork Processing Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G2/M Transition Checkpoint Response To Arsenic-containing Substance Nuclear Membrane Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Regulation Of Cellular Response To Stress Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly Protein Localization To Site Of Double-strand Break Regulation Of Double-strand Break Repair
Pathways			Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs			Ceralasertib
Diseases			Alveolar rhabdomyosarcoma Seckel syndrome
GWAS		Anticoagulant levels ( 22216198) Atrial fibrillation ( 30061737) Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling nervous ( 29500382) Feeling worry ( 29500382) Fibrinogen levels ( 26561523 28107422) General factor of neuroticism ( 30867560) High density lipoprotein cholesterol levels ( 31928498) Intraocular pressure ( 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Myocardial infarction ( 33532862) Neurofibrillary tangles ( 31497858) Neutrophil percentage of white cells ( 32888494) Schizophrenia ( 25056061 29483656) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498) Waist circumference adjusted for body mass index ( 25673412 34021172) Worry too long after an embarrassing experience ( 29500382)	Eosinophil count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 29403010 32888494) Red cell distribution width ( 28957414 32888494) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		8 interacting genes: AKAP9 ATR ATXN7L2 CDC6 HMGB1 PPP5C PTPA RBL1	58 interacting genes: AATF ABL1 AP1B1 AP3B1 APBB1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETAA1 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN NFE2L2 PA2G4 PARP1 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB RPA1 TP53 TREX1 UHRF1 UHRF2 UPF1 USP2-AS1 XPA XRCC5
Entrez ID		5523	545
HPRD ID		09225	08369
Ensembl ID		ENSG00000073711	ENSG00000175054
Uniprot IDs		Q06190	Q13535
PDB IDs		4I5J 4I5K	5YZ0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Replication Double-strand Break Repair Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Establishment Of Protein-containing Complex Localization To Telomere Regulation Of DNA Metabolic Process ATR-ATRIP Complex Histone H2AXS139 Kinase Activity Regulation Of Mitotic Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Metabolic Process Mitotic G2/M Transition Checkpoint Establishment Of RNA Localization To Telomere Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle DNA Repair Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of DNA Replication Regulation Of Protein-containing Complex Assembly Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To Oxygen-containing Compound Regulation Of Mismatch Repair C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex Calcium-dependent Protein Kinase Regulator Activity T-helper 1 Cell Activation Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Lung Development Protein Tyrosine Phosphatase Activator Activity Response To Arachidonate Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Peptidyl-serine Dephosphorylation Regulation Of Lipid Kinase Activity Dendritic Branch Maintenance Of Animal Organ Identity Ciliary Inversin Compartment Determination Of Stomach Left/right Asymmetry	DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Double-strand Break Repair Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Chromosome, Telomeric Region Mitotic DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Mitotic DNA Integrity Checkpoint Signaling DNA Recombination Negative Regulation Of Cell Cycle Phase Transition Response To Stress Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Recombinational Repair Response To Ionizing Radiation Regulation Of Cell Cycle Process Response To Radiation Damaged DNA Binding Double-strand Break Repair Via Homologous Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Radiation Chromosome Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Primary Metabolic Process Response To Gamma Radiation Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Telomere Maintenance Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition
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