PPP2R3A and AKAP9

Number of citations of the paper that reports this interaction (PMID 10358086)
50

Data Source:
HPRD (in vitro)

		PPP2R3A	AKAP9
Gene Name		protein phosphatase 2, regulatory subunit B, alpha	A kinase (PRKA) anchor protein 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex	Pericentriolar Material Golgi Apparatus Centrosome Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Ciliary Basal Body Intracellular Membrane-bounded Organelle
	Molecular Function	Calcium Ion Binding Protein Binding Protein Phosphatase Type 2A Regulator Activity	Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Complex Scaffold Ion Channel Binding
	Biological Process	Eye Photoreceptor Cell Differentiation Protein Dephosphorylation Somatic Muscle Development Positive Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity Somite Development Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Cell Motility Involved In Somitogenic Axis Elongation Positive Regulation Of Canonical Wnt Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transport Organelle Organization Signal Transduction Synaptic Transmission Spermatogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Sertoli Cell Development Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways			Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition CREB phosphorylation through the activation of Ras Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of NMDA receptor upon glutamate binding and postsynaptic events Loss of Nlp from mitotic centrosomes CREB phosphorylation through the activation of CaMKII Centrosome maturation Mitotic G2-G2/M phases Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Recruitment of mitotic centrosome proteins and complexes Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Anticoagulant levels ( 22216198)
Protein-Protein Interactions		8 interactors: AKAP9 ATXN7L2 CDC6 HMGB1 PPP2CA PPP2R4 PPP5C RBL1	43 interactors: BLZF1 C1orf94 CALM1 CALM2 CALM3 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E DISC1 FNBP1 GRIN1 HNRNPM IKZF3 KCNQ1 KDM1A MAGEA6 MAGED1 PCNT PKN1 PPP1CA PPP2R1B PPP2R3A PRDM14 PRKAR2A PRKAR2B PRKCE SAMD3 SSX2 SUV39H2 TACC3 TDP2 THAP1 TNIK TRIP10 TSG101 TSNAX TUBGCP3 USHBP1 USO1 WAC
Entrez ID		5523	10142
HPRD ID		09225	04921
Ensembl ID		ENSG00000073711	ENSG00000127914
Uniprot IDs		Q06190	Q5GIA7 Q6PJH3 Q99996
PDB IDs		4I5J 4I5K
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Process Organelle Organization Cell Cycle Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Mitotic Spindle Organization In Nucleus Negative Regulation Of Apoptotic Cell Clearance Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of DNA Replication Protein Heterooligomerization Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Regulation Of Kinase Activity Base-excision Repair, DNA Ligation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Modification Process Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Protein Dephosphorylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Metabolic Process Negative Regulation Of Phosphoprotein Phosphatase Activity Mitotic Nuclear Envelope Reassembly DNA Metabolic Process Regulation Of Protein Phosphorylation DNA Ligation Involved In DNA Repair DNA Replication Checkpoint Protein Heterotrimerization Regulation Of Apoptotic Cell Clearance Response To Organic Substance Nuclear Envelope Reassembly Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Phagocytosis Mitotic Nuclear Division Nucleobase-containing Compound Metabolic Process Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization DNA Ligation	Cell Cycle Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Organelle Organization Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity G2/M Transition Of Mitotic Cell Cycle Regulation Of Cytokinesis Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Neurotrophin Signaling Pathway Regulation Of Signaling Energy Reserve Metabolic Process Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Amphetamine Blood Coagulation Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Protein Metabolic Process Hemostasis Regulation Of Circadian Rhythm Cell Cycle Process Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Transporter Activity Response To Fibroblast Growth Factor Positive Regulation Of Protein Kinase Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Detection Of Calcium Ion Negative Regulation Of Ion Transmembrane Transport Response To Amine Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Communication By Electrical Coupling Regulation Of Cell Cycle Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Negative Regulation Of Transmembrane Transport Mitotic Cell Cycle Positive Regulation Of Transferase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation
Tagcloud ?		aza basonuclin bnc1 childhood demonstrating deoxycytidine epigenetic epigenetically fbln2 fibulin frequent frequently homeobox identification inactivated inactivation leukemia lymphoblastic methylated methylation microarray msh msx1 noti restored screens showing thrb whilst	akap450 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform mapre1 microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant
Tagcloud (Difference) ?		aza basonuclin bnc1 childhood demonstrating deoxycytidine epigenetic epigenetically fbln2 fibulin frequent frequently homeobox identification inactivated inactivation leukemia lymphoblastic methylated methylation microarray msh msx1 noti restored screens showing thrb whilst	akap450 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform mapre1 microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant
Tagcloud (Intersection) ?