PPP2R3A and PTPA

Number of citations of the paper that reports this interaction (PubMedID 18397887)
39

Data Source:
BioGRID (pull down)

		PPP2R3A	PTPA
Description		protein phosphatase 2 regulatory subunit B''alpha	protein phosphatase 2 phosphatase activator
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome ATPase Complex
	Molecular Function	Calcium Ion Binding Protein Binding Protein Phosphatase Regulator Activity Protein-macromolecule Adaptor Activity Metal Ion Binding	Nucleotide Binding Peptidyl-prolyl Cis-trans Isomerase Activity Phosphoprotein Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Isomerase Activity Phosphatase Activator Activity Protein Phosphatase Regulator Activity Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Protein Phosphatase 2A Binding
	Biological Process	Eye Photoreceptor Cell Differentiation Somitogenesis Protein Dephosphorylation Somatic Muscle Development Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Somite Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Migration Involved In Somitogenic Axis Elongation Positive Regulation Of Canonical Wnt Signaling Pathway	Mitotic Spindle Organization Positive Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Anticoagulant levels ( 22216198) Atrial fibrillation ( 30061737) Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling nervous ( 29500382) Feeling worry ( 29500382) Fibrinogen levels ( 26561523 28107422) General factor of neuroticism ( 30867560) High density lipoprotein cholesterol levels ( 31928498) Intraocular pressure ( 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Myocardial infarction ( 33532862) Neurofibrillary tangles ( 31497858) Neutrophil percentage of white cells ( 32888494) Schizophrenia ( 25056061 29483656) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498) Waist circumference adjusted for body mass index ( 25673412 34021172) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		8 interacting genes: AKAP9 ATR ATXN7L2 CDC6 HMGB1 PPP5C PTPA RBL1	32 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A GSK3B H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SGO1 SPG21 SRC SULT4A1 TEP1 TERT
Entrez ID		5523	5524
HPRD ID		09225	02858
Ensembl ID		ENSG00000073711	ENSG00000119383
Uniprot IDs		Q06190	F6WIT2 Q15257
PDB IDs		4I5J 4I5K	2G62 2HV6 2HV7 2IXM 4LAC 4NY3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Replication Double-strand Break Repair Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Establishment Of Protein-containing Complex Localization To Telomere Regulation Of DNA Metabolic Process ATR-ATRIP Complex Histone H2AXS139 Kinase Activity Regulation Of Mitotic Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Metabolic Process Mitotic G2/M Transition Checkpoint Establishment Of RNA Localization To Telomere Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle DNA Repair Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of DNA Replication Regulation Of Protein-containing Complex Assembly Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To Oxygen-containing Compound Regulation Of Mismatch Repair C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex Calcium-dependent Protein Kinase Regulator Activity T-helper 1 Cell Activation Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Lung Development Protein Tyrosine Phosphatase Activator Activity Response To Arachidonate Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Peptidyl-serine Dephosphorylation Regulation Of Lipid Kinase Activity Dendritic Branch Maintenance Of Animal Organ Identity Ciliary Inversin Compartment Determination Of Stomach Left/right Asymmetry	Regulation Of Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Protein Localization Response To Nerve Growth Factor Positive Regulation Of Cell Cycle Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Binding Mitotic Cell Cycle Phase Transition Negative Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Protein Kinase Binding Regulation Of Locomotion Positive Regulation Of Developmental Process Positive Regulation Of TOR Signaling Mitochondrion Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of TOR Signaling Response To Growth Factor
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