PPP2R3A and HMGB1

Number of citations of the paper that reports this interaction (PMID 11748221)
27

Data Source:
HPRD (in vitro)

		PPP2R3A	HMGB1
Gene Name		protein phosphatase 2, regulatory subunit B, alpha	high mobility group box 1
Image
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Cell Surface Transcriptional Repressor Complex
	Molecular Function	Calcium Ion Binding Protein Binding Protein Phosphatase Type 2A Regulator Activity	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Cytokine Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Chemoattractant Activity Poly(A) RNA Binding RAGE Receptor Binding Repressing Transcription Factor Binding
	Biological Process	Eye Photoreceptor Cell Differentiation Protein Dephosphorylation Somatic Muscle Development Positive Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity Somite Development Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Cell Motility Involved In Somitogenic Axis Elongation Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Myeloid Dendritic Cell Activation Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus DNA Topological Change Base-excision Repair, DNA Ligation Apoptotic DNA Fragmentation DNA Recombination Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Neuron Projection Development V(D)J Recombination Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Chemotaxis DNA Ligation Involved In DNA Repair Negative Regulation Of Apoptotic Cell Clearance
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Activation of DNA fragmentation factor Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs Programmed Cell Death MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Apoptotic execution phase MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Apoptosis induced DNA fragmentation Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Anticoagulant levels ( 22216198)	MRI atrophy measures ( 21116278)
Protein-Protein Interactions		8 interactors: AKAP9 ATXN7L2 CDC6 HMGB1 PPP2CA PPP2R4 PPP5C RBL1	73 interactors: AES AGER AGTRAP AR ATOH1 C14orf1 CASP3 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CUX1 DNM2 DNMT1 ERF FOXA3 FOXC1 GTF2A1 HES1 HMGA1 HNRNPK HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HR IRF2 LRIF1 MECP2 MNT NCAN NEUROD6 NFKB1 NR3C1 PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PTPRZ1 RAD23B RAG1 RASSF4 RB1 RBPJ RELA RFX1 SIX5 SOX18 TAF1 TBP TERF2 TERF2IP TFE3 TGIF1 TLE1 TLE2 TLR2 TLR4 TP53 TP73 UNC119 ZFP36 ZNF24
Entrez ID		5523	3146
HPRD ID		09225	01228
Ensembl ID		ENSG00000073711	ENSG00000189403
Uniprot IDs		Q06190	P09429 Q5T7C4
PDB IDs		4I5J 4I5K	2LY4 2YRQ
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Process Organelle Organization Cell Cycle Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Mitotic Spindle Organization In Nucleus Negative Regulation Of Apoptotic Cell Clearance Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of DNA Replication Protein Heterooligomerization Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Regulation Of Kinase Activity Base-excision Repair, DNA Ligation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Modification Process Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Protein Dephosphorylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Metabolic Process Negative Regulation Of Phosphoprotein Phosphatase Activity Mitotic Nuclear Envelope Reassembly DNA Metabolic Process Regulation Of Protein Phosphorylation DNA Ligation Involved In DNA Repair DNA Replication Checkpoint Protein Heterotrimerization Regulation Of Apoptotic Cell Clearance Response To Organic Substance Nuclear Envelope Reassembly Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Phagocytosis Mitotic Nuclear Division Nucleobase-containing Compound Metabolic Process Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization DNA Ligation	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cellular Process System Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Anterior/posterior Pattern Specification Regulation Of Cell Differentiation Pattern Specification Process
Tagcloud ?		aza basonuclin bnc1 childhood demonstrating deoxycytidine epigenetic epigenetically fbln2 fibulin frequent frequently homeobox identification inactivated inactivation leukemia lymphoblastic methylated methylation microarray msh msx1 noti restored screens showing thrb whilst	1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy index mobility pbmcs rage remarkably spondylitis surface tlr2 tlr4 untreated
Tagcloud (Difference) ?		aza basonuclin bnc1 childhood demonstrating deoxycytidine epigenetic epigenetically fbln2 fibulin frequent frequently homeobox identification inactivated inactivation leukemia lymphoblastic methylated methylation microarray msh msx1 noti restored screens showing thrb whilst	1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy index mobility pbmcs rage remarkably spondylitis surface tlr2 tlr4 untreated
Tagcloud (Intersection) ?