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PPP2R1B and RAB7A
Number of citations of the paper that reports this interaction (PMID
17540176
)
59
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
PPP2R1B
RAB7A
Gene Name
protein phosphatase 2, regulatory subunit A, beta
RAB7A, member RAS oncogene family
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Membrane Raft
Extracellular Vesicular Exosome
Lysosome
Lysosomal Membrane
Late Endosome
Vacuolar Membrane
Golgi Apparatus
Phagocytic Vesicle Membrane
Retromer Complex
Pre-autophagosomal Structure Membrane
Melanosome
Intracellular Membrane-bounded Organelle
Phagocytic Vesicle
Extracellular Vesicular Exosome
Alveolar Lamellar Body
Molecular Function
Protein Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Rac GTPase Binding
Biological Process
Apoptotic Process Involved In Morphogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Protein Targeting To Lysosome
Endocytosis
Epidermal Growth Factor Catabolic Process
Endosome To Lysosome Transport
Protein Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Protein To Membrane Docking
Rab Protein Signal Transduction
Retrograde Transport, Endosome To Golgi
Early Endosome To Late Endosome Transport
Bone Resorption
Phagosome Maturation
Phagosome Acidification
Phagosome-lysosome Fusion
Positive Regulation Of Exosomal Secretion
Regulation Of Autophagic Vacuole Assembly
Pathways
Signaling by GPCR
Integration of energy metabolism
Mitotic Prophase
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
ERKs are inactivated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Glycolysis
Signaling by Wnt
Glucose metabolism
Toll Like Receptor TLR1:TLR2 Cascade
Degradation of beta-catenin by the destruction complex
Toll Like Receptor 5 (TLR5) Cascade
RNF mutants show enhanced WNT signaling and proliferation
Myoclonic epilepsy of Lafora
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
G1/S Transition
Glycogen storage diseases
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
Beta-catenin phosphorylation cascade
Mitotic G1-G1/S phases
ERK/MAPK targets
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TRIF-mediated TLR3/TLR4 signaling
Opioid Signalling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Metabolism of carbohydrates
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
PP2A-mediated dephosphorylation of key metabolic factors
MASTL Facilitates Mitotic Progression
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
APC truncation mutants have impaired AXIN binding
Toll Like Receptor 7/8 (TLR7/8) Cascade
G2/M Transition
Mitotic Anaphase
Toll Like Receptor TLR6:TLR2 Cascade
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Activated TLR4 signalling
S37 mutants of beta-catenin aren't phosphorylated
MyD88 cascade initiated on plasma membrane
Cyclin A/B1 associated events during G2/M transition
XAV939 inhibits tankyrase, stabilizing AXIN
DARPP-32 events
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
E2F mediated regulation of DNA replication
ERKs are inactivated
Signalling by NGF
MAP kinase activation in TLR cascade
CTLA4 inhibitory signaling
G1 Phase
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Cell Cycle, Mitotic
Toll-Like Receptors Cascades
Cyclin D associated events in G1
Toll Like Receptor 10 (TLR10) Cascade
TCF dependent signaling in response to WNT
ERK/MAPK targets
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by WNT in cancer
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Nuclear Events (kinase and transcription factor activation)
MHC class II antigen presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
31 interactors:
AKAP9
ANXA5
BSG
CDK1
CDK4
CFTR
EEF2
FGFR1OP
HDAC1
HSPD1
JAK2
MCM3
PARK7
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5C
PPP2R5D
PPP2R5E
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RALA
RELA
SET
SGOL1
SGOL2
STRN
STRN3
18 interactors:
CHM
KRTAP10-3
KRTAP10-9
PPP2R1A
PPP2R1B
RAB17
RAB22A
RAB4A
RAB4B
RAB5A
RAB5B
RAB6A
RABAC1
RABGGTB
RILP
RNF115
SLC2A4
UCHL5
Entrez ID
5519
7879
HPRD ID
04384
03805
Ensembl ID
ENSG00000137713
ENSG00000075785
Uniprot IDs
P30154
C9J4V0
C9J8S3
P51149
PDB IDs
1T91
1YHN
3LAW
Enriched GO Terms of Interacting Partners
?
Mitotic Cell Cycle
Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Process
Response To Organic Substance
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Organelle Organization
Cellular Response To Stimulus
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Ras Protein Signal Transduction
Signal Transduction
Regulation Of Catalytic Activity
Response To Stimulus
Signaling
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Response To Inorganic Substance
Cell Communication
Regulation Of Cellular Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Cell Death
Response To Reactive Oxygen Species
Regulation Of Schwann Cell Differentiation
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Apoptotic Process
Neurotrophin Signaling Pathway
Regulation Of Cellular Amino Acid Metabolic Process
Response To Organic Cyclic Compound
Intracellular Signal Transduction
Hydrogen Peroxide Metabolic Process
Toll-like Receptor Signaling Pathway
Response To Oxidative Stress
Regulation Of Cell Death
Cell Division
Regulation Of Innate Immune Response
Positive Regulation Of Protein Metabolic Process
Endomembrane System Organization
G2/M Transition Of Mitotic Cell Cycle
Response To CAMP
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Metabolic Process
Chromosome Organization
Activation Of Innate Immune Response
Regulation Of Cellular Ketone Metabolic Process
Reproduction
Response To Organophosphorus
Rab Protein Signal Transduction
Ras Protein Signal Transduction
Intracellular Protein Transport
Cellular Protein Localization
Protein Transport
Small GTPase Mediated Signal Transduction
Establishment Of Protein Localization
Intracellular Transport
Regulation Of Endocytosis
Endosomal Transport
Protein Localization
Establishment Of Localization In Cell
Regulation Of Vesicle-mediated Transport
Cellular Localization
Intracellular Signal Transduction
Protein Geranylgeranylation
Glucose Import
Antigen Processing And Presentation
Protein Prenylation
Transport
Endosome Organization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Filopodium Assembly
Amylopectin Biosynthetic Process
Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation
Regulation Of Cellular Component Organization
Cytoplasmic Transport
Glucose Transport
Hexose Transport
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Peptidyl-serine Dephosphorylation
Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor
Regulation Of Vesicle Size
Vesicle-mediated Transport
Signal Transduction
Membrane Organization
Cellular Response To Stimulus
Receptor Internalization Involved In Canonical Wnt Signaling Pathway
Minus-end-directed Organelle Transport Along Microtubule
Peptidyl-cysteine Methylation
Regulation Of Endosome Size
Protein Targeting
Response To Stimulus
Endomembrane System Organization
Regulation Of Cell Projection Assembly
Immunoglobulin Transcytosis In Epithelial Cells
Signaling
Carbohydrate Transport
Cell Communication
Tagcloud
?
accelerated
anchored
apposing
confer
directionality
effectors
endomembrane
endosomal
enigmatic
exactly
golgi
gtpases
liposomes
localize
master
membrane
organelles
rab2a
rab5a
rabs
reconstitution
representative
reversible
strictly
strikingly
tethering
tethers
thoroughly
Tagcloud (Difference)
?
accelerated
anchored
apposing
confer
directionality
effectors
endomembrane
endosomal
enigmatic
exactly
golgi
gtpases
liposomes
localize
master
membrane
organelles
rab2a
rab5a
rabs
reconstitution
representative
reversible
strictly
strikingly
tethering
tethers
thoroughly
Tagcloud (Intersection)
?