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PPP2R1B and RALA
Number of citations of the paper that reports this interaction (PMID
17540176
)
59
Data Source:
HPRD
(in vivo)
PPP2R1B
RALA
Gene Name
protein phosphatase 2, regulatory subunit A, beta
v-ral simian leukemia viral oncogene homolog A (ras related)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Membrane Raft
Extracellular Vesicular Exosome
Plasma Membrane
Focal Adhesion
Cell Surface
Endocytic Vesicle
Midbody
Cytoplasmic Vesicle Membrane
Cleavage Furrow
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
GTPase Activity
Protein Binding
GTP Binding
Myosin Binding
GDP Binding
Ubiquitin Protein Ligase Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
ATPase Binding
Biological Process
Apoptotic Process Involved In Morphogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Cytokinesis
Exocytosis
Chemotaxis
Signal Transduction
Ras Protein Signal Transduction
Viral Process
Regulation Of Exocytosis
Actin Cytoskeleton Reorganization
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Filopodium Assembly
Membrane Raft Localization
Membrane Organization
Pathways
Signaling by GPCR
Integration of energy metabolism
Mitotic Prophase
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
ERKs are inactivated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Glycolysis
Signaling by Wnt
Glucose metabolism
Toll Like Receptor TLR1:TLR2 Cascade
Degradation of beta-catenin by the destruction complex
Toll Like Receptor 5 (TLR5) Cascade
RNF mutants show enhanced WNT signaling and proliferation
Myoclonic epilepsy of Lafora
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
G1/S Transition
Glycogen storage diseases
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
Beta-catenin phosphorylation cascade
Mitotic G1-G1/S phases
ERK/MAPK targets
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TRIF-mediated TLR3/TLR4 signaling
Opioid Signalling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Metabolism of carbohydrates
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
PP2A-mediated dephosphorylation of key metabolic factors
MASTL Facilitates Mitotic Progression
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
APC truncation mutants have impaired AXIN binding
Toll Like Receptor 7/8 (TLR7/8) Cascade
G2/M Transition
Mitotic Anaphase
Toll Like Receptor TLR6:TLR2 Cascade
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Activated TLR4 signalling
S37 mutants of beta-catenin aren't phosphorylated
MyD88 cascade initiated on plasma membrane
Cyclin A/B1 associated events during G2/M transition
XAV939 inhibits tankyrase, stabilizing AXIN
DARPP-32 events
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
E2F mediated regulation of DNA replication
ERKs are inactivated
Signalling by NGF
MAP kinase activation in TLR cascade
CTLA4 inhibitory signaling
G1 Phase
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Cell Cycle, Mitotic
Toll-Like Receptors Cascades
Cyclin D associated events in G1
Toll Like Receptor 10 (TLR10) Cascade
TCF dependent signaling in response to WNT
ERK/MAPK targets
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by WNT in cancer
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Nuclear Events (kinase and transcription factor activation)
Signalling to ERKs
Signalling by NGF
Signalling to RAS
p38MAPK events
Translocation of GLUT4 to the plasma membrane
NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions
31 interactors:
AKAP9
ANXA5
BSG
CDK1
CDK4
CFTR
EEF2
FGFR1OP
HDAC1
HSPD1
JAK2
MCM3
PARK7
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5C
PPP2R5D
PPP2R5E
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RALA
RELA
SET
SGOL1
SGOL2
STRN
STRN3
32 interactors:
ARF1
CALM1
CNKSR2
EXOC1
EXOC2
EXOC3
EXOC4
EXOC5
EXOC6B
EXOC7
EXOC8
FLNA
HRAS
LRPAP1
LSM2
PIH1D2
PLCD1
PLD1
PPP2R1B
RAB34
RAB8B
RALBP1
RALGPS1
RAP1A
RAP2A
RAP2B
RASSF5
REPS1
RGL2
RGL4
SMAD4
YBX3
Entrez ID
5519
5898
HPRD ID
04384
01549
Ensembl ID
ENSG00000137713
ENSG00000006451
Uniprot IDs
P30154
P11233
PDB IDs
1UAD
1ZC3
1ZC4
2A78
2A9K
2BOV
Enriched GO Terms of Interacting Partners
?
Mitotic Cell Cycle
Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Process
Response To Organic Substance
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Organelle Organization
Cellular Response To Stimulus
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Ras Protein Signal Transduction
Signal Transduction
Regulation Of Catalytic Activity
Response To Stimulus
Signaling
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Response To Inorganic Substance
Cell Communication
Regulation Of Cellular Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Cell Death
Response To Reactive Oxygen Species
Regulation Of Schwann Cell Differentiation
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Apoptotic Process
Neurotrophin Signaling Pathway
Regulation Of Cellular Amino Acid Metabolic Process
Response To Organic Cyclic Compound
Intracellular Signal Transduction
Hydrogen Peroxide Metabolic Process
Toll-like Receptor Signaling Pathway
Response To Oxidative Stress
Regulation Of Cell Death
Cell Division
Regulation Of Innate Immune Response
Positive Regulation Of Protein Metabolic Process
Endomembrane System Organization
G2/M Transition Of Mitotic Cell Cycle
Response To CAMP
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Metabolic Process
Chromosome Organization
Activation Of Innate Immune Response
Regulation Of Cellular Ketone Metabolic Process
Reproduction
Response To Organophosphorus
Exocytosis
Vesicle-mediated Transport
Small GTPase Mediated Signal Transduction
Membrane Organization
Secretion By Cell
Intracellular Signal Transduction
Secretion
Ras Protein Signal Transduction
Establishment Of Protein Localization
Protein Localization
Vesicle Docking
Protein Transport
Membrane Docking
Rap Protein Signal Transduction
Establishment Of Localization In Cell
Cellular Localization
Vesicle Docking Involved In Exocytosis
Positive Regulation Of Protein Autophosphorylation
Regulation Of Signaling
Post-Golgi Vesicle-mediated Transport
Transport
Regulation Of Protein Autophosphorylation
Organelle Organization
Regulation Of Signal Transduction
Golgi Vesicle Transport
Exocyst Localization
Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Platelet Activation
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Signaling
Cellular Protein Complex Localization
Blood Coagulation
Cell Communication
Positive Regulation Of Ras GTPase Activity
Hemostasis
Positive Regulation Of Hydrolase Activity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of GTPase Activity
Protein Complex Localization
Cellular Response To Stimulus
Regulation Of Cell Projection Organization
Regulation Of GTPase Activity
Regulation Of Ras GTPase Activity
Positive Regulation Of Metabolic Process
Positive Regulation Of Phosphorylation
Regulation Of Body Fluid Levels
Wound Healing
Golgi To Plasma Membrane Transport
Tagcloud
?
adoptive
antitumor
capability
chimeric
combining
effectors
engineered
fused
genetically
gtp
immunotherapeutic
killer
meaningful
mhc
moieties
ncr1
ncrs
nk
nkp46
partly
proto
ralb
recognition
recognize
regressions
remarkable
retrovirally
termed
Tagcloud (Difference)
?
adoptive
antitumor
capability
chimeric
combining
effectors
engineered
fused
genetically
gtp
immunotherapeutic
killer
meaningful
mhc
moieties
ncr1
ncrs
nk
nkp46
partly
proto
ralb
recognition
recognize
regressions
remarkable
retrovirally
termed
Tagcloud (Intersection)
?