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PPP2R1B and RELA
Number of citations of the paper that reports this interaction (PMID
11591705
)
22
Data Source:
HPRD
(in vitro, in vivo)
PPP2R1B
RELA
Gene Name
protein phosphatase 2, regulatory subunit A, beta
v-rel avian reticuloendotheliosis viral oncogene homolog A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Membrane Raft
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
I-kappaB/NF-kappaB Complex
Molecular Function
Protein Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein Complex Binding
Activating Transcription Factor Binding
Phosphate Ion Binding
Identical Protein Binding
Transcription Regulatory Region DNA Binding
Protein N-terminus Binding
NF-kappaB Binding
Repressing Transcription Factor Binding
Ankyrin Repeat Binding
Biological Process
Apoptotic Process Involved In Morphogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Liver Development
Hair Follicle Development
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Acetaldehyde Metabolic Process
Transcription From RNA Polymerase II Promoter
Inflammatory Response
Cellular Defense Response
Aging
Positive Regulation Of Cell Proliferation
Response To Mechanical Stimulus
Organ Morphogenesis
Response To Organic Substance
Response To UV-B
Positive Regulation Of Schwann Cell Differentiation
Viral Process
Cytokine-mediated Signaling Pathway
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Chondrocyte Differentiation
Positive Regulation Of Type I Interferon Production
Response To Muramyl Dipeptide
Response To Progesterone
Response To Insulin
Response To Cobalamin
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Negative Regulation Of Protein Catabolic Process
Response To Drug
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Amino Acid
Response To Morphine
Positive Regulation Of Interleukin-12 Biosynthetic Process
Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Insulin Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Inflammatory Response
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To CAMP
Defense Response To Virus
Cellular Response To Hydrogen Peroxide
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Nicotine
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of MiRNA Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Signaling by GPCR
Integration of energy metabolism
Mitotic Prophase
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
ERKs are inactivated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Glycolysis
Signaling by Wnt
Glucose metabolism
Toll Like Receptor TLR1:TLR2 Cascade
Degradation of beta-catenin by the destruction complex
Toll Like Receptor 5 (TLR5) Cascade
RNF mutants show enhanced WNT signaling and proliferation
Myoclonic epilepsy of Lafora
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
G1/S Transition
Glycogen storage diseases
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
Beta-catenin phosphorylation cascade
Mitotic G1-G1/S phases
ERK/MAPK targets
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TRIF-mediated TLR3/TLR4 signaling
Opioid Signalling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Metabolism of carbohydrates
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
PP2A-mediated dephosphorylation of key metabolic factors
MASTL Facilitates Mitotic Progression
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
APC truncation mutants have impaired AXIN binding
Toll Like Receptor 7/8 (TLR7/8) Cascade
G2/M Transition
Mitotic Anaphase
Toll Like Receptor TLR6:TLR2 Cascade
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Activated TLR4 signalling
S37 mutants of beta-catenin aren't phosphorylated
MyD88 cascade initiated on plasma membrane
Cyclin A/B1 associated events during G2/M transition
XAV939 inhibits tankyrase, stabilizing AXIN
DARPP-32 events
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
E2F mediated regulation of DNA replication
ERKs are inactivated
Signalling by NGF
MAP kinase activation in TLR cascade
CTLA4 inhibitory signaling
G1 Phase
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Cell Cycle, Mitotic
Toll-Like Receptors Cascades
Cyclin D associated events in G1
Toll Like Receptor 10 (TLR10) Cascade
TCF dependent signaling in response to WNT
ERK/MAPK targets
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by WNT in cancer
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Nuclear Events (kinase and transcription factor activation)
Signaling by the B Cell Receptor (BCR)
NF-kB is activated and signals survival
Downstream TCR signaling
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
RIP-mediated NFkB activation via ZBP1
Toll Like Receptor TLR6:TLR2 Cascade
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Downstream signaling events of B Cell Receptor (BCR)
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
FCERI mediated NF-kB activation
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
ZBP1(DAI) mediated induction of type I IFNs
p75NTR signals via NF-kB
Transcriptional regulation of white adipocyte differentiation
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Innate Immune System
Regulated proteolysis of p75NTR
Signalling by NGF
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
Senescence-Associated Secretory Phenotype (SASP)
Cytokine Signaling in Immune system
p75 NTR receptor-mediated signalling
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
TCR signaling
Signaling by Interleukins
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Activation of NF-kappaB in B cells
Interleukin-1 processing
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Fc epsilon receptor (FCERI) signaling
TRAF6 mediated NF-kB activation
Adaptive Immune System
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
31 interactors:
AKAP9
ANXA5
BSG
CDK1
CDK4
CFTR
EEF2
FGFR1OP
HDAC1
HSPD1
JAK2
MCM3
PARK7
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5C
PPP2R5D
PPP2R5E
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RALA
RELA
SET
SGOL1
SGOL2
STRN
STRN3
185 interactors:
AATF
ACTL6A
AES
AGO1
AHR
AKAP8
APBA2
AR
ASCC1
ASCC2
ASCC3
BATF2
BRCA1
BRMS1
BTK
BTRC
C1QB
CALM1
CAMK4
CARM1
CCL5
CDC34
CDK9
CEBPB
CEBPD
CENPJ
CHEK1
CHUK
CNNM3
COL2A1
COMMD1
CREBBP
CSNK1G1
CSNK2A1
CSNK2A2
DDC
DDX1
DHX9
DNAJA3
ECSIT
EEF1D
EGR1
EP300
ESR1
ETHE1
EZH2
FAF1
FKBP11
FOS
FUS
GOPC
GTF2B
HDAC1
HDAC2
HDAC3
HEXIM1
HMGA2
HMGB1
HSPA4
IKBKB
IKBKE
IKBKG
ING4
IRAK1BP1
IRF1
IRF2
IRF3
IRF8
IRF9
ISL1
JUN
KAT2A
KAT2B
KAT5
KDM2A
KEAP1
KPNA2
LMO2
MAP2K6
MAP3K7
MAP3K8
MAPK10
MAPK14
MED15
MED23
MED7
MEN1
MST1R
MTPN
MYC
NCOA3
NCOA6
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NKRF
NKX2-1
NOTCH1
NPM1
NR3C1
PARP1
PDCD11
PGR
PIAS1
PIAS3
PIN1
PKM
PLA2G4A
PLK1
PML
POU2F1
PPARA
PPARG
PPP1R13L
PPP2CA
PPP2CB
PPP2R1B
PPP4C
PRKACA
PRKCZ
PRMT1
PRTN3
PSMD10
REL
RELB
REPS2
RFC1
RIOK2
RNASE1
RNF25
RPL13
RPL23
RPS3
RPS6KA5
RXRA
SAT1
SETD7
SIN3A
SIRT1
SIRT6
SMAD3
SMAD4
SNIP1
SNRNP70
SOCS1
SOCS6
SORD
SP1
SRF
STAT1
STAT3
STAT6
TAF1
TAF11
TAF4B
TAF6
TAF9
TBK1
TBP
TCAP
TCF4
TERT
TGM2
TNIP2
TP53BP1
TP53BP2
TRIB3
TRIP4
TSC22D3
TWIST1
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBE2L3
UNC5CL
USF2
USP7
ZBTB7A
Entrez ID
5519
5970
HPRD ID
04384
01241
Ensembl ID
ENSG00000137713
ENSG00000173039
Uniprot IDs
P30154
Q04206
PDB IDs
1NFI
2LSP
2O61
3GUT
3QXY
3RC0
4KV1
4KV4
Enriched GO Terms of Interacting Partners
?
Mitotic Cell Cycle
Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Process
Response To Organic Substance
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Organelle Organization
Cellular Response To Stimulus
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Ras Protein Signal Transduction
Signal Transduction
Regulation Of Catalytic Activity
Response To Stimulus
Signaling
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Response To Inorganic Substance
Cell Communication
Regulation Of Cellular Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Cell Death
Response To Reactive Oxygen Species
Regulation Of Schwann Cell Differentiation
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Apoptotic Process
Neurotrophin Signaling Pathway
Regulation Of Cellular Amino Acid Metabolic Process
Response To Organic Cyclic Compound
Intracellular Signal Transduction
Hydrogen Peroxide Metabolic Process
Toll-like Receptor Signaling Pathway
Response To Oxidative Stress
Regulation Of Cell Death
Cell Division
Regulation Of Innate Immune Response
Positive Regulation Of Protein Metabolic Process
Endomembrane System Organization
G2/M Transition Of Mitotic Cell Cycle
Response To CAMP
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Metabolic Process
Chromosome Organization
Activation Of Innate Immune Response
Regulation Of Cellular Ketone Metabolic Process
Reproduction
Response To Organophosphorus
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
RNA Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Transcription, DNA-templated
RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Gene Expression
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Heterocycle Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Response To Organic Substance
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Cellular Metabolic Process
Cellular Response To Organic Substance
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Response To Stress
Negative Regulation Of Nucleic Acid-templated Transcription
Cellular Response To Stimulus
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
DNA-templated Transcription, Initiation
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Response To Stimulus
Regulation Of Cellular Process
Innate Immune Response
Regulation Of Protein Metabolic Process
Cellular Response To Stress
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud
?
balpha
bbeta
bepsilon
biochemically
casein
ck
complexed
conjugation
correspond
crel
ikappa
ikappab
ikk1
ikks
indirectly
initiates
locate
nonstimulated
okadaic
p100
p105
p90rsk1
pest
phosphorylating
purify
relb
s32
s36
serines
Tagcloud (Difference)
?
balpha
bbeta
bepsilon
biochemically
casein
ck
complexed
conjugation
correspond
crel
ikappa
ikappab
ikk1
ikks
indirectly
initiates
locate
nonstimulated
okadaic
p100
p105
p90rsk1
pest
phosphorylating
purify
relb
s32
s36
serines
Tagcloud (Intersection)
?