PPP2R1B and PPP2R5D

Number of citations of the paper that reports this interaction (PMID 16541025)
118

Data Source:
HPRD (two hybrid)

		PPP2R1B	PPP2R5D
Gene Name		protein phosphatase 2, regulatory subunit A, beta	protein phosphatase 2, regulatory subunit B, delta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Raft Extracellular Vesicular Exosome	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Energy Reserve Metabolic Process Nervous System Development Pathogenesis Dephosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Stress-activated MAPK Cascade
Pathways		Signaling by GPCR Integration of energy metabolism Mitotic Prophase misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling G1/S Transition Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade Mitotic G1-G1/S phases ERK/MAPK targets truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors MASTL Facilitates Mitotic Progression Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding Toll Like Receptor 7/8 (TLR7/8) Cascade G2/M Transition Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN DARPP-32 events MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System E2F mediated regulation of DNA replication ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling G1 Phase NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Toll-Like Receptors Cascades Cyclin D associated events in G1 Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Nuclear Events (kinase and transcription factor activation)	Signaling by GPCR Integration of energy metabolism misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade ERK/MAPK targets truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids Toll Like Receptor 7/8 (TLR7/8) Cascade APC truncation mutants have impaired AXIN binding Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane DARPP-32 events XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKAP9 ANXA5 BSG CDK1 CDK4 CFTR EEF2 FGFR1OP HDAC1 HSPD1 JAK2 MCM3 PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA SET SGOL1 SGOL2 STRN STRN3	9 interactors: CHEK2 FSD2 HAND1 HAND2 PPFIA1 PPP2R1B PPP4C SGOL1 USHBP1
Entrez ID		5519	5528
HPRD ID		04384	09039
Ensembl ID		ENSG00000137713	ENSG00000112640
Uniprot IDs		P30154	Q14738
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Response To Organic Substance Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Organization Cellular Response To Stimulus Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Ras Protein Signal Transduction Signal Transduction Regulation Of Catalytic Activity Response To Stimulus Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Inorganic Substance Cell Communication Regulation Of Cellular Process MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Cell Death Response To Reactive Oxygen Species Regulation Of Schwann Cell Differentiation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Response To Organic Cyclic Compound Intracellular Signal Transduction Hydrogen Peroxide Metabolic Process Toll-like Receptor Signaling Pathway Response To Oxidative Stress Regulation Of Cell Death Cell Division Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Endomembrane System Organization G2/M Transition Of Mitotic Cell Cycle Response To CAMP Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Metabolic Process Chromosome Organization Activation Of Innate Immune Response Regulation Of Cellular Ketone Metabolic Process Reproduction Response To Organophosphorus	Cardiac Right Ventricle Formation Cardiac Ventricle Formation Cardiac Chamber Formation Cartilage Morphogenesis Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Morphogenesis Regulation Of Transcription Regulatory Region DNA Binding Apoptotic Process Involved In Development Developmental Programmed Cell Death Negative Regulation Of DNA Binding Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Cardiac Ventricle Morphogenesis Embryonic Heart Tube Development Regulation Of DNA Binding Embryonic Heart Tube Formation Signal Transduction Involved In Intra-S DNA Damage Checkpoint Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Negative Regulation Of Binding Odontogenesis Of Dentin-containing Tooth Cardiac Ventricle Development Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cardiac Left Ventricle Formation Cell Proliferation Involved In Outflow Tract Morphogenesis Visceral Serous Pericardium Development Odontogenesis Cardiac Chamber Development Apoptotic Process Involved In Heart Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Cartilage Development Mesenchyme Development Centriole-centriole Cohesion Norepinephrine Biosynthetic Process Heart Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Coronary Artery Morphogenesis Noradrenergic Neuron Differentiation Apoptotic Process Connective Tissue Development Programmed Cell Death Regulation Of Binding Positive Regulation Of Transcription Regulatory Region DNA Binding Cell Death Death Negative Regulation Of Stress Fiber Assembly
Tagcloud ?			altering cacnb4 concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Difference) ?			altering cacnb4 concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Intersection) ?