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PPP2R1B and RAB11A
Number of citations of the paper that reports this interaction (PMID
17540176
)
59
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
PPP2R1B
RAB11A
Gene Name
protein phosphatase 2, regulatory subunit A, beta
RAB11A, member RAS oncogene family
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Membrane Raft
Extracellular Vesicular Exosome
Spindle Pole
Mitochondrion
Multivesicular Body
Trans-Golgi Network
Kinetochore Microtubule
Cytosol
Plasma Membrane
Transport Vesicle
Axon
Cytoplasmic Vesicle Membrane
Phagocytic Vesicle Membrane
Cytoplasmic Vesicle
Vesicle
Cleavage Furrow
Protein Complex
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Recycling Endosome
Recycling Endosome Membrane
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
GTPase Activity
Protein Binding
GTP Binding
Microtubule Binding
GDP Binding
Syntaxin Binding
Myosin V Binding
Biological Process
Apoptotic Process Involved In Morphogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Cytokinesis
Renal Water Homeostasis
Water Transport
Intracellular Protein Transport
Exocytosis
Organelle Organization
Mitotic Metaphase Plate Congression
Positive Regulation Of Epithelial Cell Migration
Regulation Of Multivesicular Body Size
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Vesicle-mediated Transport
Astral Microtubule Organization
Neuron Projection Development
Melanosome Transport
Rab Protein Signal Transduction
Multivesicular Body Assembly
Positive Regulation Of Axon Extension
Regulation Of Long-term Neuronal Synaptic Plasticity
Plasma Membrane To Endosome Transport
Regulation Of Protein Transport
Establishment Of Vesicle Localization
Transmembrane Transport
Regulation Of Vesicle-mediated Transport
Establishment Of Protein Localization To Organelle
Protein Localization To Plasma Membrane
Establishment Of Protein Localization To Membrane
Mitotic Spindle Assembly
Exosomal Secretion
Pathways
Signaling by GPCR
Integration of energy metabolism
Mitotic Prophase
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
ERKs are inactivated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Glycolysis
Signaling by Wnt
Glucose metabolism
Toll Like Receptor TLR1:TLR2 Cascade
Degradation of beta-catenin by the destruction complex
Toll Like Receptor 5 (TLR5) Cascade
RNF mutants show enhanced WNT signaling and proliferation
Myoclonic epilepsy of Lafora
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
G1/S Transition
Glycogen storage diseases
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
Beta-catenin phosphorylation cascade
Mitotic G1-G1/S phases
ERK/MAPK targets
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TRIF-mediated TLR3/TLR4 signaling
Opioid Signalling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Metabolism of carbohydrates
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
PP2A-mediated dephosphorylation of key metabolic factors
MASTL Facilitates Mitotic Progression
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
APC truncation mutants have impaired AXIN binding
Toll Like Receptor 7/8 (TLR7/8) Cascade
G2/M Transition
Mitotic Anaphase
Toll Like Receptor TLR6:TLR2 Cascade
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Activated TLR4 signalling
S37 mutants of beta-catenin aren't phosphorylated
MyD88 cascade initiated on plasma membrane
Cyclin A/B1 associated events during G2/M transition
XAV939 inhibits tankyrase, stabilizing AXIN
DARPP-32 events
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
E2F mediated regulation of DNA replication
ERKs are inactivated
Signalling by NGF
MAP kinase activation in TLR cascade
CTLA4 inhibitory signaling
G1 Phase
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Cell Cycle, Mitotic
Toll-Like Receptors Cascades
Cyclin D associated events in G1
Toll Like Receptor 10 (TLR10) Cascade
TCF dependent signaling in response to WNT
ERK/MAPK targets
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by WNT in cancer
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Nuclear Events (kinase and transcription factor activation)
Cargo trafficking to the periciliary membrane
Organelle biogenesis and maintenance
Vasopressin regulates renal water homeostasis via Aquaporins
Translocation of GLUT4 to the plasma membrane
VxPx cargo-targeting to cilium
Assembly of the primary cilium
Aquaporin-mediated transport
Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions
31 interactors:
AKAP9
ANXA5
BSG
CDK1
CDK4
CFTR
EEF2
FGFR1OP
HDAC1
HSPD1
JAK2
MCM3
PARK7
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5C
PPP2R5D
PPP2R5E
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RALA
RELA
SET
SGOL1
SGOL2
STRN
STRN3
28 interactors:
CHMP1B
CHMP3
DTNBP1
GDI2
IKBKG
KAT2B
MYO5A
MYO5B
OPTN
PPP2R1A
PPP2R1B
PSEN1
PSEN2
PTGIR
RAB11FIP1
RAB11FIP2
RAB11FIP3
RAB11FIP4
RAB11FIP5
RAB3IL1
RABGGTB
RCHY1
SEC13
STX4
TBXA2R
TDP2
WDR44
YWHAG
Entrez ID
5519
8766
HPRD ID
04384
05715
Ensembl ID
ENSG00000137713
ENSG00000103769
Uniprot IDs
P30154
P62491
PDB IDs
1OIV
1OIW
1OIX
1YZK
2D7C
2GZD
2GZH
2HV8
4C4P
Enriched GO Terms of Interacting Partners
?
Mitotic Cell Cycle
Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Process
Response To Organic Substance
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Organelle Organization
Cellular Response To Stimulus
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Ras Protein Signal Transduction
Signal Transduction
Regulation Of Catalytic Activity
Response To Stimulus
Signaling
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Response To Inorganic Substance
Cell Communication
Regulation Of Cellular Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Cell Death
Response To Reactive Oxygen Species
Regulation Of Schwann Cell Differentiation
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Apoptotic Process
Neurotrophin Signaling Pathway
Regulation Of Cellular Amino Acid Metabolic Process
Response To Organic Cyclic Compound
Intracellular Signal Transduction
Hydrogen Peroxide Metabolic Process
Toll-like Receptor Signaling Pathway
Response To Oxidative Stress
Regulation Of Cell Death
Cell Division
Regulation Of Innate Immune Response
Positive Regulation Of Protein Metabolic Process
Endomembrane System Organization
G2/M Transition Of Mitotic Cell Cycle
Response To CAMP
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Metabolic Process
Chromosome Organization
Activation Of Innate Immune Response
Regulation Of Cellular Ketone Metabolic Process
Reproduction
Response To Organophosphorus
Protein Transport
Establishment Of Protein Localization
Protein Localization
Establishment Of Localization In Cell
Cellular Localization
Organelle Localization
Vesicle-mediated Transport
Establishment Of Organelle Localization
Establishment Of Vesicle Localization
Vesicle Localization
Transport
Exocytosis
Regulation Of Signal Transduction
Post-Golgi Vesicle-mediated Transport
Membrane Organization
Intracellular Transport
Regulation Of Signaling
Golgi Vesicle Transport
Cell Death
Death
Insulin Secretion
Secretion By Cell
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Synaptic Transmission
Negative Regulation Of Protein Phosphorylation
Regulation Of Catalytic Activity
Regulated Secretory Pathway
Regulation Of Synaptic Plasticity
Regulation Of Body Fluid Levels
Amyloid Precursor Protein Catabolic Process
Cell-cell Signaling
Peptide Hormone Secretion
Secretion
Peptide Secretion
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Phosphorylation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Signaling
Apoptotic Process
Cell Cycle
Cell Communication
Negative Regulation Of Protein Kinase Activity
Programmed Cell Death
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Cell Cycle Process
Negative Regulation Of Kinase Activity
Hormone Secretion
Regulation Of Protein Kinase Activity
Beta-amyloid Metabolic Process
Amyloid Precursor Protein Metabolic Process
Tagcloud
?
c2
compartments
displays
fip
fip1
fip2
fip3
fip5
fips
gtpases
hela
illumination
integral
lactc2
live
membranes
microscopy
overlap
overlapped
overlapping
pericentriolar
phosphatidylserine
probe
ps
recycling
structured
tubular
Tagcloud (Difference)
?
c2
compartments
displays
fip
fip1
fip2
fip3
fip5
fips
gtpases
hela
illumination
integral
lactc2
live
membranes
microscopy
overlap
overlapped
overlapping
pericentriolar
phosphatidylserine
probe
ps
recycling
structured
tubular
Tagcloud (Intersection)
?