PPP2R1B and RAB11A

Number of citations of the paper that reports this interaction (PubMedID 17540176)
58

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PPP2R1B	RAB11A
Description		protein phosphatase 2 scaffold subunit Abeta	RAB11A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol Membrane Raft Extracellular Exosome	Golgi Membrane Spindle Pole Cytoplasm Endosome Multivesicular Body Golgi Apparatus Trans-Golgi Network Centrosome Centriole Kinetochore Microtubule Cytosol Plasma Membrane Endosome Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cleavage Furrow Trans-Golgi Network Membrane Protein-containing Complex Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynaptic Endosome Postsynaptic Recycling Endosome Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Microtubule Binding Hydrolase Activity Syntaxin Binding Myosin V Binding Dynein Light Intermediate Chain Binding
	Biological Process	Spindle Assembly Meiotic Sister Chromatid Cohesion, Centromeric Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Mitotic Cytokinesis Exocytosis Vesicle Docking Involved In Exocytosis Microtubule-based Movement Mitotic Metaphase Chromosome Alignment Positive Regulation Of Epithelial Cell Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Vesicle-mediated Transport Astral Microtubule Organization Neuron Projection Development Melanosome Transport Regulation Of Cytokinesis Protein Localization To Cell Surface Multivesicular Body Assembly Golgi To Plasma Membrane Protein Transport Positive Regulation Of Cilium Assembly Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Protein Transport Establishment Of Vesicle Localization Regulation Of Vesicle-mediated Transport Early Endosome To Recycling Endosome Transport Protein Localization To Cilium Protein Transmembrane Transport Establishment Of Protein Localization To Organelle Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Mitotic Spindle Assembly Vesicle-mediated Transport To The Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Synaptic Vesicle Endosomal Processing Amyloid-beta Clearance By Transcytosis Regulation Of Cilium Assembly Regulation Of Early Endosome To Recycling Endosome Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Protein Localization To Centrosome Protein Localization To Cleavage Furrow Exosomal Secretion Regulation Of Endocytic Recycling
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Translocation of SLC2A4 (GLUT4) to the plasma membrane Vasopressin regulates renal water homeostasis via Aquaporins Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation
Drugs			5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red blood cell count ( 32888494)	Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 27863252 29403010 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		42 interacting genes: AKAP9 ANXA5 BHLHE41 BSG CDK1 CDK4 CEP43 CFTR CLOCK CRY1 CRY2 CSNK2B DELEC1 EEF2 FBXW11 HDAC1 HSPD1 JAK2 MCM3 OGT PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA RORC SET SGO1 SGO2 STRN STRN3 UBC UNC5B	32 interacting genes: ARF6 CHMP1B CHMP3 DTNBP1 GDI2 IKBKG KAT2B MYO5A MYO5B OPTN PPP2R1A PPP2R1B PSEN1 PSEN2 PTGIR RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP4 RAB11FIP5 RAB13 RAB3IL1 RAB3IP RAB8A RABGGTB RCHY1 SEC13 SNCA STX4 TBXA2R TDP2 WDR44
Entrez ID		5519	8766
HPRD ID		04384	05715
Ensembl ID		ENSG00000137713	ENSG00000103769
Uniprot IDs		P30154	P62491
PDB IDs			1OIV 1OIW 1OIX 1YZK 2D7C 2GZD 2GZH 2HV8 4C4P 4D0L 4D0M 4LWZ 4LX0 4UJ3 4UJ4 4UJ5 5C46 5C4G 5EUQ 5EZ5 5FBL 5FBQ 5FBR 5FBV 5FBW 5JCZ 6DJL 6IXV 8VOF
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex Circadian Regulation Of Gene Expression Protein Phosphatase Regulator Activity Cytosol Rhythmic Process Circadian Rhythm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peroxiredoxin Activity Regulation Of Circadian Rhythm Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Sister Chromatid Cohesion Sister Chromatid Cohesion Cellular Response To Stress Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Removal Of Superoxide Radicals FAR/SIN/STRIPAK Complex Protein Phosphatase Activator Activity E-box Binding Positive Regulation Of Circadian Rhythm Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Intracellular Receptor Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Schwann Cell Differentiation Response To Oxidative Stress Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Glucocorticoid Secretion Photoperiodism Regulation Of Programmed Cell Death Response To Reactive Oxygen Species Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Signaling Pathway Protein Phosphatase 2A Binding Thioredoxin-dependent Peroxiredoxin Activity Nucleotide Binding Cytoplasm Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signal Transduction Negative Regulation Of Neuron Apoptotic Process	Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Protein Localization Recycling Endosome Endosome Small GTPase Binding Recycling Endosome Membrane Organelle Localization Establishment Of Localization In Cell Vesicle-mediated Transport To The Plasma Membrane Cellular Localization Organelle Localization By Membrane Tethering Membrane Docking Intracellular Transport Negative Regulation Of Adiponectin Secretion Endosomal Transport Post-Golgi Vesicle-mediated Transport Midbody Protein Localization To Plasma Membrane Cytosol Exocytosis Golgi To Plasma Membrane Transport Protein Localization To Cell Periphery Endocytic Recycling Cytoplasmic Vesicle Localization Within Membrane Kinetochore Golgi Vesicle Transport Cytoplasmic Vesicle Membrane Negative Regulation Of Cell Projection Organization Protein Localization To Membrane Neuron Projection Establishment Of Protein Localization To Plasma Membrane Golgi Apparatus Cytoplasm Vesicle Docking Synaptic Vesicle Regulation Of Protein Localization Organelle Assembly Organelle Organization Regulation Of Vesicle-mediated Transport Regulation Of Organelle Assembly Secretion By Cell Protein Localization To Cleavage Furrow Endocytic Vesicle Regulation Of Secretion By Cell Regulation Of Receptor Recycling Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Cell Communication
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