PPP2R1B and STRN3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PPP2R1B	STRN3
Description		protein phosphatase 2 scaffold subunit Abeta	striatin 3
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol Membrane Raft Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Membrane Dendrite Protein-containing Complex Neuronal Cell Body FAR/SIN/STRIPAK Complex Postsynapse
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity	Protein Binding Calmodulin Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding
	Biological Process	Spindle Assembly Meiotic Sister Chromatid Cohesion, Centromeric Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Response To Estradiol Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Hippo Signaling Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red blood cell count ( 32888494)	Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		42 interacting genes: AKAP9 ANXA5 BHLHE41 BSG CDK1 CDK4 CEP43 CFTR CLOCK CRY1 CRY2 CSNK2B DELEC1 EEF2 FBXW11 HDAC1 HSPD1 JAK2 MCM3 OGT PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA RORC SET SGO1 SGO2 STRN STRN3 UBC UNC5B	10 interacting genes: CALM1 GABARAPL1 MOB1A NR3C1 PPP2R1A PPP2R1B PPP2R2A SIKE1 SLC2A4 TCEANC
Entrez ID		5519	29966
HPRD ID		04384	11613
Ensembl ID		ENSG00000137713	ENSG00000196792
Uniprot IDs		P30154	Q13033
PDB IDs			4N6J 6AKL 6IUR 7K36
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex Circadian Regulation Of Gene Expression Protein Phosphatase Regulator Activity Cytosol Rhythmic Process Circadian Rhythm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peroxiredoxin Activity Regulation Of Circadian Rhythm Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Sister Chromatid Cohesion Sister Chromatid Cohesion Cellular Response To Stress Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Removal Of Superoxide Radicals FAR/SIN/STRIPAK Complex Protein Phosphatase Activator Activity E-box Binding Positive Regulation Of Circadian Rhythm Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Intracellular Receptor Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Schwann Cell Differentiation Response To Oxidative Stress Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Glucocorticoid Secretion Photoperiodism Regulation Of Programmed Cell Death Response To Reactive Oxygen Species Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Signaling Pathway Protein Phosphatase 2A Binding Thioredoxin-dependent Peroxiredoxin Activity Nucleotide Binding Cytoplasm Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signal Transduction Negative Regulation Of Neuron Apoptotic Process	Protein Phosphatase Type 2A Complex Protein Phosphatase Regulator Activity Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion FAR/SIN/STRIPAK Complex Negative Regulation Of Hippo Signaling Cytosol Sister Chromatid Cohesion Regulation Of Hippo Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Nuclear Glucocorticoid Receptor Activity Meiotic Spindle Elongation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Serine/threonine Kinase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Spindle Assembly Protein Kinase Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Positive Regulation Of Programmed Cell Death Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Chromosome Segregation Positive Regulation Of Apoptotic Process Nuclear Receptor-mediated Corticosteroid Signaling Pathway Steroid Hormone Binding Positive Regulation Of Apoptotic Signaling Pathway Mitotic Sister Chromatid Separation Spindle Elongation Insulin-responsive Compartment Glucose Import In Response To Insulin Stimulus White Fat Cell Proliferation Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking Response To Cortisol Spindle Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Vesicle Negative Regulation Of Voltage-gated Calcium Channel Activity
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