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PPP2R1B and PRDX2
Number of citations of the paper that reports this interaction (PubMedID
17540176
)
58
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
PPP2R1B
PRDX2
Description
protein phosphatase 2 scaffold subunit Abeta
peroxiredoxin 2
Image
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Nucleus
Cytoplasm
Cytosol
Membrane Raft
Extracellular Exosome
Cytoplasm
Cytosol
Extracellular Exosome
Molecular Function
Protein Binding
Protein Phosphatase Regulator Activity
Peroxidase Activity
Protein Binding
Thioredoxin Peroxidase Activity
Antioxidant Activity
Oxidoreductase Activity
Peroxiredoxin Activity
Thioredoxin-dependent Peroxiredoxin Activity
Biological Process
Spindle Assembly
Meiotic Sister Chromatid Cohesion, Centromeric
Apoptotic Process Involved In Morphogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Defense Response To Tumor Cell
Respiratory Burst Involved In Inflammatory Response
Response To Oxidative Stress
Regulation Of Hydrogen Peroxide Metabolic Process
Removal Of Superoxide Radicals
Positive Regulation Of Blood Coagulation
Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Response To Lipopolysaccharide
Cellular Response To Oxidative Stress
T Cell Proliferation
Hydrogen Peroxide Metabolic Process
Hydrogen Peroxide Catabolic Process
Regulation Of Apoptotic Process
T Cell Homeostasis
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Leukocyte Activation
Cell Redox Homeostasis
Negative Regulation Of T Cell Differentiation
Thymus Development
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
3-sulfino-L-alanine
N-Carbamoyl-Alanine
Copper
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Asthma (
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Brain morphology (MOSTest) (
32665545
)
Fish- and plant-related diet (
32066663
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Red blood cell count (
32888494
)
Platelet distribution width (
32888494
)
Interacting Genes
42 interacting genes:
AKAP9
ANXA5
BHLHE41
BSG
CDK1
CDK4
CEP43
CFTR
CLOCK
CRY1
CRY2
CSNK2B
DELEC1
EEF2
FBXW11
HDAC1
HSPD1
JAK2
MCM3
OGT
PARK7
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5C
PPP2R5D
PPP2R5E
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RALA
RELA
RORC
SET
SGO1
SGO2
STRN
STRN3
UBC
UNC5B
24 interacting genes:
A2M
APOE
APP
BAD
CA4
CD320
CDC37
CDK1
COPS5
ECSIT
EXOC6
IFIT5
MAST1
NLGN3
PDGFRB
PPP2R1A
PPP2R1B
PSEN1
RNF32
RPL4
SAT1
SUMO4
TXNDC5
UTY
Entrez ID
5519
7001
HPRD ID
04384
02763
Ensembl ID
ENSG00000137713
ENSG00000167815
Uniprot IDs
P30154
P32119
V9HW12
PDB IDs
1QMV
5B8A
5B8B
5IJT
7KIZ
7KJ0
7KJ1
Enriched GO Terms of Interacting Partners
?
Protein Phosphatase Type 2A Complex
Circadian Regulation Of Gene Expression
Protein Phosphatase Regulator Activity
Cytosol
Rhythmic Process
Circadian Rhythm
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Peroxiredoxin Activity
Regulation Of Circadian Rhythm
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Signal Transduction
Signal Transduction
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Meiotic Sister Chromatid Cohesion
Sister Chromatid Cohesion
Cellular Response To Stress
Blue Light Signaling Pathway
DNA (6-4) Photolyase Activity
Deoxyribodipyrimidine Photo-lyase Activity
Blue Light Photoreceptor Activity
Removal Of Superoxide Radicals
FAR/SIN/STRIPAK Complex
Protein Phosphatase Activator Activity
E-box Binding
Positive Regulation Of Circadian Rhythm
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Intracellular Signal Transduction
Intracellular Receptor Signaling Pathway
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Schwann Cell Differentiation
Response To Oxidative Stress
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Glucocorticoid Secretion
Photoperiodism
Regulation Of Programmed Cell Death
Response To Reactive Oxygen Species
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Apoptotic Signaling Pathway
Protein Phosphatase 2A Binding
Thioredoxin-dependent Peroxiredoxin Activity
Nucleotide Binding
Cytoplasm
Positive Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Signal Transduction
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Amyloid Fibril Formation
Regulation Of Amyloid Fibril Formation
Lipoprotein Particle
Regulation Of Protein Localization To Nucleus
Astrocyte Activation Involved In Immune Response
Meiotic Sister Chromatid Cohesion, Centromeric
Intermediate-density Lipoprotein Particle
Growth Factor Receptor Binding
Rough Endoplasmic Reticulum
Positive Regulation Of Protein Transport
Positive Regulation Of Protein Localization
Cellular Response To Amyloid-beta
Positive Regulation Of Apoptotic Signaling Pathway
Extracellular Exosome
Positive Regulation Of Establishment Of Protein Localization
Regulation Of Signal Transduction
Positive Regulation Of Signaling
Response To Amyloid-beta
Regulation Of Apoptotic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Meiotic Sister Chromatid Cohesion
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Long-term Synaptic Potentiation
Regulation Of Programmed Cell Death
Regulation Of Dendritic Spine Maintenance
Neuron Projection Maintenance
Enzyme Binding
Positive Regulation Of Proteolysis
Low-density Lipoprotein Particle
Regulation Of Protein Localization
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Apoptotic Signaling Pathway
Protein Phosphatase Type 2A Complex
Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Heparan Sulfate Proteoglycan Binding
Astrocyte Activation
Negative Regulation Of DNA Binding
Regulation Of Immune Response
Regulation Of Innate Immune Response
Very-low-density Lipoprotein Particle
Regulation Of Amyloid-beta Clearance
Regulation Of Protein Transport
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Protein Localization To Nucleus
High-density Lipoprotein Particle
Dendrite
Positive Regulation Of Glycolytic Process
Amyloid Precursor Protein Metabolic Process
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Tagcloud (Intersection)
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