PPP2R1B and RAB18

Number of citations of the paper that reports this interaction (PMID 17540176)
59

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PPP2R1B	RAB18
Gene Name		protein phosphatase 2, regulatory subunit A, beta	RAB18, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Raft Extracellular Vesicular Exosome	Intracellular Golgi Apparatus Plasma Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Eye Development Intracellular Protein Transport Small GTPase Mediated Signal Transduction Brain Development Rab Protein Signal Transduction Lipid Particle Organization Endoplasmic Reticulum Tubular Network Organization
Pathways		Signaling by GPCR Integration of energy metabolism Mitotic Prophase misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling G1/S Transition Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade Mitotic G1-G1/S phases ERK/MAPK targets truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors MASTL Facilitates Mitotic Progression Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding Toll Like Receptor 7/8 (TLR7/8) Cascade G2/M Transition Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN DARPP-32 events MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System E2F mediated regulation of DNA replication ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling G1 Phase NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Toll-Like Receptors Cascades Cyclin D associated events in G1 Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKAP9 ANXA5 BSG CDK1 CDK4 CFTR EEF2 FGFR1OP HDAC1 HSPD1 JAK2 MCM3 PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA SET SGOL1 SGOL2 STRN STRN3	6 interactors: CHM PDE6D PPP2R1A PPP2R1B TAX1BP1 TOM1L1
Entrez ID		5519	22931
HPRD ID		04384	03731
Ensembl ID		ENSG00000137713	ENSG00000099246
Uniprot IDs		P30154	B7Z4P9 B7Z5V3 Q9NP72
PDB IDs			1X3S
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Response To Organic Substance Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Organization Cellular Response To Stimulus Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Ras Protein Signal Transduction Signal Transduction Regulation Of Catalytic Activity Response To Stimulus Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Inorganic Substance Cell Communication Regulation Of Cellular Process MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Cell Death Response To Reactive Oxygen Species Regulation Of Schwann Cell Differentiation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Response To Organic Cyclic Compound Intracellular Signal Transduction Hydrogen Peroxide Metabolic Process Toll-like Receptor Signaling Pathway Response To Oxidative Stress Regulation Of Cell Death Cell Division Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Endomembrane System Organization G2/M Transition Of Mitotic Cell Cycle Response To CAMP Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Metabolic Process Chromosome Organization Activation Of Innate Immune Response Regulation Of Cellular Ketone Metabolic Process Reproduction Response To Organophosphorus	Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Peptidyl-serine Dephosphorylation Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Cell Death Death Protein Geranylgeranylation Mitotic Nuclear Envelope Reassembly Nuclear Envelope Reassembly Regulation Of Apoptotic Process Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Death Protein Prenylation Negative Regulation Of JAK-STAT Cascade Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Apoptotic Process Involved In Morphogenesis
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