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PPP2R1B and PPP2R2A
Number of citations of the paper that reports this interaction (PMID
17540176
)
59
Data Source:
HPRD
(in vivo, in vitro)
PPP2R1B
PPP2R2A
Gene Name
protein phosphatase 2, regulatory subunit A, beta
protein phosphatase 2, regulatory subunit B, alpha
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Membrane Raft
Extracellular Vesicular Exosome
Protein Phosphatase Type 2A Complex
Nucleoplasm
Cytosol
Molecular Function
Protein Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
Biological Process
Apoptotic Process Involved In Morphogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
G2/M Transition Of Mitotic Cell Cycle
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Mitotic Cell Cycle
Protein Dephosphorylation
Mitotic Nuclear Envelope Reassembly
Signal Transduction
Gene Expression
Response To Morphine
Regulation Of Catalytic Activity
Pathways
Signaling by GPCR
Integration of energy metabolism
Mitotic Prophase
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
ERKs are inactivated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Glycolysis
Signaling by Wnt
Glucose metabolism
Toll Like Receptor TLR1:TLR2 Cascade
Degradation of beta-catenin by the destruction complex
Toll Like Receptor 5 (TLR5) Cascade
RNF mutants show enhanced WNT signaling and proliferation
Myoclonic epilepsy of Lafora
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
G1/S Transition
Glycogen storage diseases
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
Beta-catenin phosphorylation cascade
Mitotic G1-G1/S phases
ERK/MAPK targets
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TRIF-mediated TLR3/TLR4 signaling
Opioid Signalling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Metabolism of carbohydrates
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
PP2A-mediated dephosphorylation of key metabolic factors
MASTL Facilitates Mitotic Progression
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
APC truncation mutants have impaired AXIN binding
Toll Like Receptor 7/8 (TLR7/8) Cascade
G2/M Transition
Mitotic Anaphase
Toll Like Receptor TLR6:TLR2 Cascade
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Activated TLR4 signalling
S37 mutants of beta-catenin aren't phosphorylated
MyD88 cascade initiated on plasma membrane
Cyclin A/B1 associated events during G2/M transition
XAV939 inhibits tankyrase, stabilizing AXIN
DARPP-32 events
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
E2F mediated regulation of DNA replication
ERKs are inactivated
Signalling by NGF
MAP kinase activation in TLR cascade
CTLA4 inhibitory signaling
G1 Phase
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Cell Cycle, Mitotic
Toll-Like Receptors Cascades
Cyclin D associated events in G1
Toll Like Receptor 10 (TLR10) Cascade
TCF dependent signaling in response to WNT
ERK/MAPK targets
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by WNT in cancer
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Nuclear Events (kinase and transcription factor activation)
Nonsense-Mediated Decay (NMD)
G1 Phase
G2/M Transition
Mitotic Anaphase
Cell Cycle, Mitotic
M Phase
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Cyclin D associated events in G1
Cyclin A/B1 associated events during G2/M transition
Nuclear Envelope Reassembly
Initiation of Nuclear Envelope Reformation
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Height (
23563607
)
Protein-Protein Interactions
31 interactors:
AKAP9
ANXA5
BSG
CDK1
CDK4
CFTR
EEF2
FGFR1OP
HDAC1
HSPD1
JAK2
MCM3
PARK7
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5C
PPP2R5D
PPP2R5E
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RALA
RELA
SET
SGOL1
SGOL2
STRN
STRN3
12 interactors:
ATR
CHEK2
GRIN1
GRIN2D
MTOR
NDRG1
PPP2CA
PPP2R1A
PPP2R1B
RRN3
STRN3
TGFBR1
Entrez ID
5519
5520
HPRD ID
04384
09223
Ensembl ID
ENSG00000137713
ENSG00000221914
Uniprot IDs
P30154
P63151
PDB IDs
3DW8
Enriched GO Terms of Interacting Partners
?
Mitotic Cell Cycle
Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Process
Response To Organic Substance
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Organelle Organization
Cellular Response To Stimulus
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Ras Protein Signal Transduction
Signal Transduction
Regulation Of Catalytic Activity
Response To Stimulus
Signaling
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Response To Inorganic Substance
Cell Communication
Regulation Of Cellular Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Cell Death
Response To Reactive Oxygen Species
Regulation Of Schwann Cell Differentiation
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Apoptotic Process
Neurotrophin Signaling Pathway
Regulation Of Cellular Amino Acid Metabolic Process
Response To Organic Cyclic Compound
Intracellular Signal Transduction
Hydrogen Peroxide Metabolic Process
Toll-like Receptor Signaling Pathway
Response To Oxidative Stress
Regulation Of Cell Death
Cell Division
Regulation Of Innate Immune Response
Positive Regulation Of Protein Metabolic Process
Endomembrane System Organization
G2/M Transition Of Mitotic Cell Cycle
Response To CAMP
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Metabolic Process
Chromosome Organization
Activation Of Innate Immune Response
Regulation Of Cellular Ketone Metabolic Process
Reproduction
Response To Organophosphorus
Regulation Of DNA Replication
Regulation Of Signaling
Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Mitotic Nuclear Envelope Reassembly
Regulation Of Signal Transduction
Nuclear Envelope Reassembly
Positive Regulation Of Transcription, DNA-templated
Peptidyl-serine Phosphorylation
Nucleus Organization
Replicative Senescence
Positive Regulation Of Macromolecule Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Gene Expression
Double-strand Break Repair
Negative Regulation Of JAK-STAT Cascade
Positive Regulation Of Cellular Biosynthetic Process
Apoptotic Process
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Programmed Cell Death
Startle Response
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Process
Regulation Of Intracellular Signal Transduction
Cell Death
Regulation Of Cellular Response To Heat
Death
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Response To Fibroblast Growth Factor
Negative Regulation Of Signal Transduction
Inactivation Of MAPK Activity
Cell Development
Response To Abiotic Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intracellular Signal Transduction
Signal Transduction
Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Autophosphorylation
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Regulation Of Cellular Component Organization
Negative Regulation Of Signaling
Positive Regulation Of Cell Death
Developmental Process
Synaptic Transmission, Glutamatergic
Tagcloud
?
22q13
alterations
analyzing
brca1
candidates
computational
developments
drive
driver
estimates
estimating
generations
genomes
genomic
identifies
instability
lineage
mutator
mutators
neutral
passenger
passengers
prkdc
somatic
take
technologies
throughput
timing
tumorigenesis
Tagcloud (Difference)
?
22q13
alterations
analyzing
brca1
candidates
computational
developments
drive
driver
estimates
estimating
generations
genomes
genomic
identifies
instability
lineage
mutator
mutators
neutral
passenger
passengers
prkdc
somatic
take
technologies
throughput
timing
tumorigenesis
Tagcloud (Intersection)
?